Best Over-the-Counter Psoriasis Treatments

1. Hydrocortisone Cream

Hydrocortisone cream is a widely available over-the-counter remedy for managing mild psoriasis symptoms. It contains a low-strength corticosteroid (generally 0.5-1%) that works by suppressing the inflammatory response in the skin, which helps reduce redness, swelling, and the persistent itching associated with psoriasis. While hydrocortisone is not as potent as prescription-strength topical steroids, it can provide temporary relief for localized flare-ups and sensitive skin areas, such as the face and folds.

Compared to prescription corticosteroids, OTC hydrocortisone is less likely to cause side effects like skin thinning or systemic absorption, especially when used as directed. However, it is important to use hydrocortisone only on affected areas and to avoid prolonged or excessive application. Overuse can lead to skin irritation, increased risk of infection, or diminished effectiveness over time. Individuals should consult a healthcare provider if symptoms persist beyond one week, if large body areas are involved, or if the condition worsens. For more detailed guidance, visit the American Academy of Dermatology’s overview of topical psoriasis treatments.

2. Coal Tar Preparations

Coal tar is one of the oldest treatments for psoriasis, recognized for its ability to reduce inflammation, slow skin cell growth, and diminish scaling and itching. These anti-inflammatory and antiproliferative properties make coal tar a valuable addition to over-the-counter options for plaque psoriasis. Coal tar is available in various forms, including shampoos, creams, ointments, and bath solutions, making it versatile for treating both scalp and body symptoms.

Despite its efficacy, coal tar has some practical drawbacks. Its distinctive, lingering odor can be off-putting for some users, and the dark coloration may stain clothing, bedding, and even light hair. To minimize staining, apply products sparingly and allow them to dry before dressing or use at night with old garments and linens. For those with sensitive skin, it’s advisable to test a small area first, as coal tar can sometimes cause irritation or photosensitivity. For more information on coal tar’s use and safety in psoriasis management, consult the National Psoriasis Foundation’s guide on coal tar treatments.

3. Salicylic Acid Ointments

Salicylic acid is a keratolytic agent commonly found in over-the-counter ointments and creams for psoriasis. Its main role is to soften and loosen the thick, scaly plaques that characterize the condition, making it easier to remove scales and improve skin texture. This mechanism is similar to salicylic acid’s use in acne treatments, where it helps unclog pores and exfoliate the skin. By facilitating the removal of surface build-up, salicylic acid can enhance the effectiveness of other topical therapies and promote smoother, less irritated skin.

However, caution is warranted when using salicylic acid ointments. Overuse can lead to excessive skin dryness, irritation, or even chemical burns, especially on sensitive or large areas of the body. Individuals with extensive psoriasis should avoid applying salicylic acid to large skin surfaces to reduce the risk of systemic absorption, which can cause additional health complications. It is best to follow package directions closely and consult a healthcare professional if experiencing increased redness, stinging, or prolonged irritation. For more detailed recommendations, visit the American Academy of Dermatology’s salicylic acid resource.

4. Moisturizing Creams and Lotions

Moisturizing is a cornerstone of psoriasis self-care, helping to combat the persistent dryness and itchiness associated with the condition. Regular use of moisturizers can improve skin barrier function, reduce flaking, and enhance comfort. Thick ointments, such as petroleum jelly or heavy creams, are particularly effective because they lock in moisture and provide a protective layer over the skin. These options are ideal for very dry or cracked areas, as they are more occlusive than lighter lotions.

Lighter lotions, on the other hand, are easier to spread and may be preferable for use during the day or on less affected areas. However, they may require more frequent application to sustain hydration. When selecting a moisturizer, it is advisable to choose fragrance-free and dye-free products, as added scents and colors can irritate sensitive, psoriasis-prone skin. Look for ingredients such as ceramides, hyaluronic acid, or glycerin, which help retain moisture and support skin repair. For additional guidance on choosing the right moisturizer for psoriasis, visit the National Psoriasis Foundation’s moisturizing tips.

5. Aloe Vera Gel

Aloe vera gel is a popular natural remedy valued for its soothing and anti-inflammatory effects, especially in managing mild psoriasis symptoms. The gel, extracted from the leaves of the aloe vera plant, is known to provide a cooling sensation, reduce redness, and help ease itching. Several studies suggest that topical aloe vera can offer mild improvement in psoriasis plaques, particularly when used consistently over several weeks. For instance, a review published in the journal Phytotherapy Research highlights aloe vera’s potential in reducing scaling and discomfort.

When using aloe vera gel, it is important to choose products with high concentrations of pure aloe and minimal additives, as artificial fragrances and preservatives can aggravate sensitive skin. While generally considered safe, some individuals may experience allergic reactions such as redness, burning, or rash upon application. It is wise to perform a patch test on a small area before widespread use. If irritation or an allergic response occurs, discontinue use and consult a healthcare provider. For more information on aloe vera’s benefits and safety in skin care, review the American Academy of Dermatology’s guidance on aloe vera.

6. Oatmeal Baths

Colloidal oatmeal, made from finely ground oats, is a time-tested remedy for soothing itchy and irritated skin, making it a beneficial option for those with psoriasis. Its effectiveness in reducing itch and inflammation has been well documented in both psoriasis and eczema care. Colloidal oatmeal forms a protective barrier on the skin, helping to lock in moisture, ease dryness, and provide immediate relief from discomfort. This gentle ingredient is often recommended in dermatology for its minimal risk of side effects and natural calming properties.

Oatmeal baths are easy to prepare at home by adding a cup of colloidal oatmeal to a bathtub filled with lukewarm water. Soak for 10-15 minutes, then gently pat the skin dry to avoid irritation. To enhance the benefits, moisturize immediately after bathing. Avoid using hot water or harsh soaps, as these can exacerbate dryness and itching. Colloidal oatmeal products should be fragrance-free to minimize the risk of irritation. For more information on the use of oatmeal baths for psoriasis and practical tips, visit the American Academy of Dermatology’s guide to oatmeal baths.

7. Calamine Lotion

Calamine lotion is a classic over-the-counter remedy best known for its ability to soothe irritated, itchy skin. Composed of zinc oxide and ferric oxide, calamine provides a cooling effect that helps calm itchiness and mild inflammation, making it a suitable option for some individuals with psoriasis, especially during acute flare-ups. While calamine lotion is not a targeted psoriasis treatment, its gentle properties offer temporary relief from discomfort and can be especially useful for those who prefer non-steroidal solutions.

Compared to other anti-itch lotions, such as hydrocortisone or colloidal oatmeal formulations, calamine is less likely to thin the skin or cause irritation with repeated use. However, it may be less effective at addressing the underlying inflammation and scaling associated with psoriasis. It is most beneficial when applied to small, localized patches rather than widespread plaques. If calamine lotion does not provide noticeable relief, or if the skin becomes increasingly red, swollen, or painful, it is important to seek further medical advice. Persistent or worsening symptoms may require prescription medications or a more comprehensive treatment plan. For more on calamine’s uses and guidance, review the WebMD calamine topical guide.

8. Vitamin D Analogue Creams

Vitamin D analogue creams are a cornerstone of prescription psoriasis care due to their ability to slow abnormal skin cell growth and reduce inflammation. These creams mimic the action of vitamin D in the skin, helping to normalize the excessive turnover of skin cells that characterizes psoriasis. While prescription formulations like calcipotriene are highly effective, over-the-counter options containing vitamin D derivatives, such as topical creams with vitamin D3 (cholecalciferol), are available in some countries as supportive care products.

In the United States, OTC vitamin D analogue creams are less widely available or regulated than in Europe or other regions. However, some non-prescription creams and ointments include vitamin D or are marketed for general skin health, though their potency and efficacy for psoriasis may be significantly less than prescription versions. These products may offer mild benefits, particularly for those with very mild plaques or as adjuncts to other therapies. It’s essential to check product labels carefully and consult a healthcare professional before use, especially if combining with other treatments. For an overview of vitamin D’s role in psoriasis management, visit the National Psoriasis Foundation’s resource on vitamin D.

9. Zinc Pyrithione Shampoos

Zinc pyrithione is a well-established active ingredient in many over-the-counter dandruff shampoos, valued for its antifungal, antibacterial, and anti-inflammatory properties. For individuals with scalp psoriasis, zinc pyrithione shampoos can help reduce persistent itching, flaking, and mild redness by targeting the underlying inflammation and controlling the growth of microbes that can exacerbate symptoms. These shampoos are particularly beneficial for those with overlapping dandruff and mild-to-moderate scalp psoriasis.

To use zinc pyrithione shampoo for scalp psoriasis, gently massage the product into the scalp and leave it on for several minutes before rinsing to maximize its therapeutic effect. Regular use—usually two to three times per week—can help maintain symptom control and improve scalp comfort. While zinc pyrithione is generally considered safe, it may cause dryness or irritation in some individuals, so it’s important to monitor for any adverse effects. Using a fragrance-free conditioner afterward can help soothe and hydrate the scalp. For more information about zinc pyrithione and guidance on managing scalp psoriasis, visit the National Psoriasis Foundation’s scalp psoriasis resource.

10. Epsom Salt Soaks

Epsom salt, or magnesium sulfate, is a popular home remedy for alleviating discomfort associated with psoriasis. When dissolved in bathwater, Epsom salts release minerals that can help soften rough patches, reduce scaling, and offer temporary relief from itching and irritation. This mineral-rich soak is similar in concept to Dead Sea salt therapy, which has been studied for its beneficial effects on chronic skin conditions due to its unique blend of minerals like magnesium, potassium, and calcium.

To safely enjoy an Epsom salt soak, add approximately one to two cups of Epsom salt to a bathtub filled with lukewarm water. Soak for 10 to 15 minutes, as extended exposure can increase dryness for some individuals. Always avoid hot water, which can further irritate and dehydrate sensitive skin. After bathing, gently pat the skin dry and immediately apply a moisturizer to lock in hydration. While Epsom salt baths are generally safe, those with open sores or sensitive skin should consult their healthcare provider before use. For more details on mineral bath therapies for psoriasis, visit the National Psoriasis Foundation’s guidance on bath solutions.

11. Coconut Oil

Coconut oil is a natural emollient rich in medium-chain fatty acids, such as lauric acid, which provide deep moisturization and help restore the skin’s protective barrier. This nourishing property can be particularly beneficial for individuals with psoriasis, as it helps soften and loosen thick scales while reducing dryness and discomfort. Coconut oil’s texture and absorption make it a practical choice for treating stubborn plaques, especially on the scalp and elbows—areas often resistant to lighter moisturizers.

When compared to mineral oil, another common over-the-counter remedy, coconut oil offers additional antimicrobial benefits and is often preferred by those seeking natural alternatives. Both oils effectively trap moisture in the skin, but coconut oil’s pleasant scent and ease of use make it a popular choice for daily care. To use, gently warm a small amount of oil and massage it into affected areas, allowing it to penetrate for several minutes before rinsing or shampooing, especially for scalp psoriasis. For best results, apply after bathing when the skin is still slightly damp. For more information on coconut oil and natural emollients for psoriasis, visit the National Psoriasis Foundation’s resource on natural remedies.

12. Shea Butter

Shea butter is a rich, natural fat derived from the nuts of the African shea tree and is widely celebrated for its intense emollient and skin-protective properties. Used for centuries in African skincare, shea butter provides deep hydration, soothes irritation, and helps reinforce the skin’s barrier—qualities particularly valuable for managing psoriasis. Its dense, creamy texture locks in moisture and creates a protective layer that can reduce flakiness and alleviate persistent dryness associated with plaque formation.

Shea butter is also packed with vitamins A and E, which may contribute to skin healing and overall comfort. It is often found in both pure form and as a base ingredient in many over-the-counter creams and ointments for sensitive or dry skin. For those using prescription topical treatments, shea butter can be layered as a final step after the medication has fully absorbed—this helps seal in active ingredients and maximize moisture retention. Always ensure the skin is clean, and allow prescription products to dry before applying shea butter to prevent dilution. For further details on shea butter’s benefits and its use in psoriasis care, consult the National Institutes of Health review on shea butter in dermatology.

13. Emollient Ointments (Petrolatum-Based)

Petrolatum-based emollient ointments, such as petroleum jelly, are highly effective at forming an occlusive barrier over the skin. This barrier significantly reduces water loss, helps maintain skin hydration, and protects against external irritants—making petrolatum an excellent choice for managing the dryness and scaling seen in psoriasis. Compared to lighter lotions or creams, petrolatum-based ointments are thicker and longer-lasting, making them particularly useful for areas prone to persistent dryness or cracking, such as elbows, knees, and feet.

Due to their heavy, greasy texture, petrolatum ointments are often best suited for nighttime use. Apply a generous layer to affected areas before bed and cover with soft cotton clothing or gloves to enhance absorption and prevent transfer onto sheets. This practice, sometimes called “occlusion therapy,” helps maximize the ointment’s moisturizing effects overnight. While petrolatum is non-irritating and generally safe for most people, it is important to apply it only to intact skin and avoid use on open wounds. For additional information on petrolatum and its role in psoriasis skin care, visit the American Academy of Dermatology’s moisturizing guide.

14. Ceramide-Boosted Creams

Ceramides are essential lipids naturally present in the outermost layer of the skin, where they play a critical role in maintaining the skin’s barrier and retaining moisture. In psoriasis, the skin’s barrier is often compromised, leading to increased dryness, irritation, and susceptibility to environmental triggers. Ceramide-boosted creams are specifically formulated to replenish these vital lipids, supporting skin repair and resilience. By restoring ceramide levels, these creams help soothe and protect sensitive, psoriasis-prone skin while reducing flaking and discomfort.

Popular over-the-counter brands, such as CeraVe and Eucerin, offer moisturizers enriched with multiple types of ceramides, often combined with other hydrating ingredients like hyaluronic acid and glycerin. These formulations are typically non-greasy, fragrance-free, and well-tolerated by even the most sensitive skin types. Ceramide creams can be used daily and layered beneath heavier ointments or prescription treatments for enhanced benefit. For individuals seeking gentle, restorative care, ceramide-boosted products offer a science-backed approach to managing psoriasis symptoms. For further reading on ceramides and recommended products, visit the National Psoriasis Foundation’s overview of ceramides in skincare.

15. Urea Creams

Urea is a powerful keratolytic agent found in many over-the-counter creams for psoriasis. Its unique ability to break down and soften thickened, scaly skin makes it particularly useful for treating stubborn plaques on areas such as the elbows, knees, and feet. Urea not only helps exfoliate excess skin cells but also draws moisture into the skin, providing a dual benefit of smoothing and hydrating rough patches. This mechanism is somewhat similar to salicylic acid, which also loosens scales, but urea is generally considered less irritating for sensitive or compromised skin.

Despite its moisturizing properties, urea creams may cause a mild stinging or burning sensation, especially when applied to cracked or inflamed skin. This side effect is usually temporary, but individuals with very sensitive skin should start with lower concentrations and increase as tolerated. Urea creams are often combined with other emollients to maximize comfort and efficacy. For optimal results, apply urea cream after bathing when the skin is still slightly damp, and always follow the product’s instructions. For more information on the science and safe use of urea in psoriasis care, visit the National Institutes of Health review on urea in dermatology.

16. Glycerin-Based Moisturizers

Glycerin, also known as glycerol, is a highly effective humectant found in many over-the-counter moisturizers for psoriasis. Its key feature is its ability to attract and retain water from the environment and deeper skin layers, drawing moisture into the outer skin barrier and providing lasting hydration. This moisture-boosting action helps reduce dryness, flaking, and tightness that often accompany psoriatic plaques. Glycerin’s effectiveness is comparable to that of hyaluronic acid, another popular humectant, though glycerin is typically less expensive and less likely to cause irritation.

To maximize benefits, glycerin-based moisturizers can be applied immediately after bathing, while the skin is still damp, to help lock in moisture. For even better results, layer a petrolatum-based ointment or thick cream over the glycerin moisturizer to create an occlusive barrier and prevent water loss. This “layering” technique is especially helpful for those with moderate to severe dryness. Glycerin-based moisturizers are generally well tolerated and suitable for sensitive skin, often being fragrance-free and hypoallergenic. For more details on the science and application of glycerin in psoriasis care, see the National Psoriasis Foundation’s guide to glycerin in skincare.

17. Non-Soap Cleansers

Non-soap cleansers, also known as syndet (synthetic detergent) bars or washes, are specially formulated to clean the skin without the harshness of traditional soaps. Unlike conventional soaps, which can strip the skin of natural oils and disrupt the protective barrier, non-soap cleansers maintain the skin’s moisture balance—an essential factor for those with psoriasis. These gentle cleansers are pH-balanced and free from strong detergents, making them less likely to cause dryness, irritation, or flare-ups.

Popular dermatologist-recommended brands such as Cetaphil, Dove Sensitive Skin, and Vanicream offer non-soap cleansers that are widely available over the counter. These products are often fragrance-free, hypoallergenic, and suitable for daily use on sensitive, psoriasis-prone skin. Non-soap cleansers can be used on both the face and body, helping to remove dirt and excess oil while leaving the skin feeling soft and hydrated. For best results, cleanse with lukewarm water and avoid scrubbing the affected areas. For further guidance and a list of dermatologist-recommended non-soap cleansers, visit the American Academy of Dermatology’s skin cleansing tips.

18. Tea Tree Oil Products

Tea tree oil is a natural essential oil derived from the leaves of the Melaleuca alternifolia plant, known for its potent anti-inflammatory and antimicrobial properties. These qualities have made tea tree oil a popular ingredient in over-the-counter creams, shampoos, and ointments designed to help soothe psoriasis symptoms, particularly itching, redness, and minor irritation. Some studies suggest that tea tree oil may also help reduce the risk of secondary infections in areas where the skin is broken or compromised.

Because tea tree oil is highly concentrated, it should always be diluted before topical use to minimize the potential for skin irritation or allergic reactions. Patch testing a small amount on an unaffected area is recommended before widespread application. Compared to eucalyptus oil, which also offers anti-inflammatory benefits, tea tree oil is generally considered more effective for antimicrobial protection but may be more likely to cause sensitization in sensitive individuals. Both oils should be used with caution and discontinued if any burning, redness, or rash develops. For more information on tea tree oil, its potential benefits, and safe use in psoriasis care, visit the National Psoriasis Foundation’s resource on tea tree oil.

19. Dead Sea Salt Scrubs

Dead Sea salt scrubs are prized for their high concentration of minerals such as magnesium, potassium, and calcium, which are believed to provide therapeutic benefits for various skin conditions, including psoriasis. These minerals can help soften rough plaques, reduce scaling, and support overall skin health by enhancing hydration and soothing inflammation. Dead Sea salts are often regarded as more mineral-rich compared to Epsom salts, which primarily contain magnesium sulfate. This unique mineral profile has led to the widespread use of Dead Sea salt scrubs and soaks as part of self-care routines for people with chronic skin issues.

While Dead Sea salt scrubs can gently exfoliate and remove surface scales, it is important to use them with care to avoid aggravating sensitive or inflamed skin. Always apply with gentle, circular motions and avoid scrubbing broken or severely irritated areas. After rinsing, moisturize the skin to help restore hydration and prevent excessive dryness. Individuals with very sensitive skin should consider using Dead Sea salts in bath soaks instead of scrubs for milder exfoliation. For further details about Dead Sea salt’s benefits and safe exfoliation practices, visit the National Psoriasis Foundation’s bath solutions page.

20. Baking Soda Pastes

Baking soda, or sodium bicarbonate, is a common household ingredient that can be used as a mild exfoliant and pH balancer for the skin. When mixed with water to form a paste, baking soda offers gentle exfoliation, helping to remove surface scales and smooth rough patches associated with psoriasis. Its alkaline nature can also help neutralize excess acidity on the skin, which some believe may contribute to irritation and discomfort. Unlike commercial scrubs that often contain fragrances, dyes, or coarse particles, baking soda pastes are simple and free from common irritants, making them a budget-friendly option for mild, localized exfoliation.

Despite these benefits, overuse of baking soda can disrupt the skin’s natural barrier and lead to increased dryness or sensitivity. It is important to use baking soda pastes sparingly—no more than once or twice a week—and to avoid applying to broken, inflamed, or very sensitive skin. Always rinse thoroughly and follow up with a gentle, fragrance-free moisturizer to restore hydration. For those with highly sensitive skin, commercial scrubs specifically formulated for psoriasis may be safer alternatives. For more guidance on baking soda’s use and precautions, see the National Psoriasis Foundation’s natural remedies page.

21. Mentholated Lotions

Mentholated lotions provide a soothing, cooling sensation that can offer temporary relief from itching and discomfort associated with psoriasis. Menthol, derived from peppermint oil, activates cold-sensitive receptors in the skin, creating a cooling effect that helps distract from itch and irritation. This counterirritant mechanism is particularly useful during flare-ups when itching is intense and persistent. Mentholated lotions are available over the counter and are often formulated with additional moisturizing ingredients to support skin hydration.

Compared to camphor, another common counterirritant, menthol is generally milder and more widely used in topical preparations for itch relief. Both ingredients work by stimulating sensory nerves and providing a cooling or tingling sensation, but camphor can be more irritating or sensitizing for certain skin types. Users should be aware that mentholated lotions, while effective for short-term comfort, may cause sensitivity, redness, or allergic reactions, especially with frequent or prolonged use. It is advisable to perform a patch test and avoid using menthol products on broken or severely inflamed skin. For more information about menthol’s role in managing skin conditions, visit the American Academy of Dermatology’s guide to managing itchy skin.

22. Avocado Oil

Avocado oil is a nutrient-rich, plant-based oil extracted from the flesh of avocados. It contains an abundance of vitamins A, D, and E, as well as essential fatty acids like oleic acid, all of which contribute to its moisturizing, anti-inflammatory, and skin-repairing properties. These nutrients help nourish dry, irritated skin and support the skin’s natural barrier—making avocado oil a valuable option for individuals with psoriasis, especially those struggling with persistent, stubborn plaques.

Compared to olive oil, another common emollient, avocado oil is lighter in texture and absorbs more readily, making it less likely to leave a greasy residue. Both oils provide beneficial antioxidants and fatty acids, but avocado oil’s higher vitamin content may offer additional skin-soothing effects. To use, gently warm a small amount of oil and massage it into affected areas, allowing it to soften scales and hydrate rough patches. It can also be used as an overnight treatment by applying a thicker layer and covering with soft cotton fabric. For more information on the benefits and safe use of avocado oil in psoriasis care, visit the National Psoriasis Foundation’s page on natural remedies.

23. Witch Hazel

Witch hazel is a plant-derived astringent that contains natural tannins, known for their anti-inflammatory and soothing effects on the skin. Widely used in over-the-counter toners and skin care products, witch hazel may help reduce redness, itching, and mild swelling associated with psoriasis flares. Its gentle astringency can also assist in minimizing oozing or weeping from irritated plaques, making it a versatile addition to skin care routines for those with sensitive or inflamed skin.

Compared to other astringent toners that often contain alcohol or synthetic additives, pure witch hazel is generally less drying and better tolerated by sensitive skin types. However, some commercial witch hazel products are formulated with alcohol, which can exacerbate dryness and irritation—so it is important to choose alcohol-free varieties when caring for psoriasis-prone skin. Before regular use, apply a small amount of witch hazel to a patch of unaffected skin to check for any adverse reactions, as some individuals may experience stinging or increased sensitivity. For further information on witch hazel’s properties and recommendations for use in dermatology, see the American Academy of Dermatology’s resource on witch hazel.

24. Apple Cider Vinegar

Apple cider vinegar (ACV) is a popular natural remedy used to relieve itching and discomfort, particularly in cases of scalp psoriasis. Its natural acidity helps restore the skin’s pH balance and may provide mild antimicrobial benefits, which can be useful for soothing irritated, flaky patches on the scalp. Many people turn to ACV as an inexpensive, readily available option for loosening scales and reducing itch on areas where hair makes topical treatment challenging.

To safely use apple cider vinegar, always dilute it with water—typically mixing one part vinegar to three or four parts water—before applying it to the scalp with a spray bottle or cotton ball. This dilution helps minimize the risk of chemical burns or excessive stinging, which can occur if vinegar is applied full-strength, especially to cracked or bleeding skin. After a few minutes, rinse thoroughly with cool water. Individuals with open sores, severe irritation, or very sensitive skin should avoid using ACV. For more information about the safe use of apple cider vinegar for scalp psoriasis, visit the National Psoriasis Foundation’s page on apple cider vinegar.

25. Shea and Cocoa Butter Blend

The combination of shea butter and cocoa butter in a single blend creates a deeply moisturizing and nourishing product ideal for managing the dryness and flakiness often experienced with psoriasis. Shea butter is known for its rich emollient effect and high content of vitamins A and E, which support skin barrier repair and reduce irritation. Cocoa butter, on the other hand, is prized for its smooth texture and natural antioxidants, which help protect and soften the skin. When used together, these butters provide enhanced hydration, locking in moisture more effectively than either ingredient alone.

Compared to single butters, a blend delivers a balance of richness and spreadability, making it suitable for daily application on larger body areas or stubborn plaques. This combination is particularly useful after bathing or showering, when the skin is most receptive to moisture. For best results, choose products that are free from artificial fragrances and dyes to reduce the risk of irritation. Consistent daily use can help maintain skin suppleness, minimize scaling, and improve overall comfort. For more on the benefits of shea and cocoa butter in skin care, see the National Psoriasis Foundation’s natural remedies page.

26. Glycerin Soap

Glycerin soap is widely regarded for its gentle cleansing properties, making it particularly suitable for individuals with psoriasis or sensitive skin. Unlike traditional soaps that often contain harsh detergents, fragrances, or dyes, glycerin soap is formulated to cleanse without stripping the skin’s natural oils. Glycerin acts as a humectant, attracting moisture to the skin’s surface and helping to maintain hydration during and after washing. This makes glycerin soap less likely to exacerbate dryness or trigger flare-ups compared to conventional soaps.

Many hypoallergenic brands, such as Vanicream and Clearly Natural, offer fragrance-free and dye-free glycerin soaps specifically designed for sensitive and psoriasis-prone skin. These products provide effective cleansing while minimizing the risk of irritation or allergic reactions. When choosing a glycerin soap, look for simple ingredient lists and avoid unnecessary additives. Use lukewarm water and avoid scrubbing the skin vigorously to maintain the skin barrier. For additional guidance on selecting and using gentle cleansers for psoriasis care, visit the American Academy of Dermatology’s recommendations for skin cleansing.

27. Emu Oil

Emu oil is derived from the fat of the emu, a flightless bird native to Australia, and is promoted for its purported anti-inflammatory and skin-soothing properties. Advocates suggest that emu oil can help reduce redness, itching, and irritation associated with psoriasis due to its unique blend of fatty acids, including oleic, linoleic, and palmitic acids. Some small studies and anecdotal reports note improvements in moisture retention and comfort, although robust clinical evidence is limited compared to more established plant-based oils.

When compared to plant-based oils such as coconut, olive, or avocado oil, emu oil is similarly effective at sealing in moisture and softening dry, flaky skin. However, it is not vegan-friendly, and sourcing raises ethical and sustainability concerns for some consumers. If you choose to use emu oil, look for products from reputable companies that adhere to humane and environmentally responsible practices. As with any topical product, perform a patch test to check for sensitivities or allergic reactions. For more information on emu oil and its place in psoriasis management, consult the National Psoriasis Foundation’s natural remedies section.

28. Calendula Cream

Calendula cream is made from the extracts of Calendula officinalis, also known as marigold, a botanical ingredient prized for its soothing and anti-inflammatory effects on the skin. Calendula is often used in over-the-counter creams and ointments to calm redness, reduce minor irritation, and support the healing process in sensitive or inflamed areas. Its gentle action makes it a popular choice for those with psoriasis, particularly when dealing with dry, chapped, or easily irritated plaques.

Compared to chamomile, another botanical remedy known for its anti-inflammatory and calming properties, calendula is similarly gentle but may have a slightly stronger effect on promoting tissue repair and reducing swelling. Both botanicals are well tolerated by most people, but individuals with plant allergies or sensitive skin should always perform a patch test before widespread use. It’s best to choose calendula creams that are free of artificial fragrances and harsh preservatives to minimize the risk of adverse reactions. For more information on calendula and its use in dermatology, see the National Institutes of Health review on calendula for skin health.

29. Dead Sea Mud Masks

Dead Sea mud masks are enriched with minerals such as magnesium, calcium, and potassium, which are naturally found in the Dead Sea’s unique geological composition. These minerals contribute to the mud’s hydrating, anti-inflammatory, and detoxifying properties, making Dead Sea mud masks a popular adjunct in the care of psoriasis-prone skin. When applied topically, the mud can help draw out impurities, gently exfoliate dead skin cells, and soothe areas of redness or irritation.

Compared to standard clay masks—like those made from kaolin or bentonite—Dead Sea mud masks are generally more hydrating and less likely to over-dry the skin. While clay masks can be effective for oily or acne-prone skin, their strong oil-absorbing action may exacerbate dryness in individuals with psoriasis. Dead Sea mud, in contrast, offers a more balanced mineral profile and is better suited to sensitive or dry skin types. For best results, use a Dead Sea mud mask no more than once or twice per week, and always follow with a gentle moisturizer. For further information on the benefits and safe use of Dead Sea mud for skin, visit the National Psoriasis Foundation’s bath solutions resource.

30. Fragrance-Free Body Washes

Fragrance-free body washes are essential for individuals with psoriasis, as added scents in skincare products are a common cause of irritation, allergic reactions, and flare-ups. Fragrances—both synthetic and natural—can disrupt the skin barrier, leading to increased dryness, redness, and sensitivity, especially in those with compromised skin. Therefore, opting for fragrance-free formulas is a safer choice compared to scented body washes, which might contain hidden irritants even if labeled as “natural” or “gentle.”

Dermatologist-recommended brands such as Cetaphil, Vanicream, Eucerin, and CeraVe offer body washes specifically formulated without fragrances, dyes, or harsh detergents. These products are designed to cleanse the skin gently, preserving its natural moisture and reducing the likelihood of irritation. When selecting a body wash, look for labels indicating “fragrance-free” rather than “unscented,” as the latter may still contain masking agents. For best results, use lukewarm water, avoid vigorous scrubbing, and follow with a rich, fragrance-free moisturizer. For more recommendations and evidence on choosing safe cleansers for psoriasis, visit the American Academy of Dermatology’s bathing and cleansing guide.

31. Omega-3 Fatty Acid Supplements

Omega-3 fatty acids, found in fish oil and certain plant sources, are known for their potent anti-inflammatory effects that may benefit individuals with psoriasis. Research suggests that omega-3s—particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—can help reduce systemic inflammation, which is a key factor in psoriasis flare-ups. Some studies indicate that regular supplementation may lead to milder symptoms and improved skin comfort, although results can vary among individuals.

While eating fatty fish such as salmon, mackerel, and sardines is an excellent way to increase dietary omega-3 intake, supplements provide a concentrated dose for those who may not consume fish regularly. However, supplements are not a substitute for a balanced diet and should not be relied upon as a sole treatment. It is crucial to discuss omega-3 supplementation with a healthcare provider before starting, as high doses can interact with medications, affect blood clotting, and may not be suitable for everyone. For more on the role of omega-3 fatty acids in managing psoriasis, see the National Psoriasis Foundation’s page on omega-3s.

32. Vitamin B12 Creams

Vitamin B12 creams are gaining popularity in psoriasis care due to their role in supporting healthy skin cell growth and reducing inflammation. Vitamin B12, or cobalamin, is essential for DNA synthesis and cellular repair, making it a valuable ingredient in topical formulations for chronic skin conditions. Some small studies suggest that regular application of B12-enriched creams may help alleviate mild psoriasis symptoms, such as redness, scaling, and itching, particularly when used as part of a comprehensive skincare routine.

Compared to multivitamin creams that blend several nutrients, B12-specific creams focus on delivering a targeted dose of cobalamin directly to the affected area. This can enhance absorption and maximize potential benefits, whereas multivitamin products may dilute the effect or introduce unnecessary additives. While research is ongoing, initial results are promising, especially for individuals seeking non-steroidal, over-the-counter options. As with any topical product, it is advisable to perform a patch test to check for sensitivities. For more information on the science and potential of vitamin B12 creams in psoriasis care, visit the National Institutes of Health review on topical vitamin B12 for psoriasis.

33. Lactic Acid Lotions

Lactic acid is an alpha hydroxy acid (AHA) commonly found in over-the-counter lotions for psoriasis and other dry skin conditions. It acts as a gentle exfoliant, helping to break down and remove dead skin cells while also drawing moisture into the skin. This dual action can soften thick plaques, reduce scaling, and improve overall skin texture, making lactic acid lotions a useful addition to psoriasis management routines.

When compared to urea, another popular keratolytic and humectant, lactic acid offers similar benefits in exfoliating and moisturizing the skin. However, lactic acid may be more suitable for individuals with mild to moderate scaling, while urea creams—especially those with higher concentrations—are often preferred for very thick or stubborn plaques. Because both ingredients can sometimes cause stinging or irritation, particularly on sensitive or broken skin, it’s best to introduce lactic acid lotions gradually. Start with a lower concentration and apply to a small area at first, increasing frequency and coverage as tolerated.

For more information on the use of lactic acid in skin care and its benefits for psoriasis, see the National Psoriasis Foundation’s guide to skin care products.

34. Antihistamine Creams

Antihistamine creams, commonly containing ingredients like diphenhydramine, provide short-term relief from itching by blocking the action of histamine in the skin. These topical products can be helpful for individuals with psoriasis who experience intense itching during flare-ups, offering fast-acting, localized comfort without the potential drowsiness associated with oral antihistamines. Applied directly to affected areas, antihistamine creams can help break the itch-scratch cycle and reduce the urge to scratch, which may otherwise worsen irritation or cause skin injury.

Compared to oral antihistamines, which work systemically and are often used for allergy-related itch, topical antihistamines deliver targeted relief but are not intended for widespread or long-term use. Overuse of these creams can lead to skin sensitization, allergic reactions, or, in rare cases, systemic absorption, especially when used on large body areas or broken skin. As a result, it is important to use antihistamine creams only as directed and to seek medical advice if itching persists or recurs frequently. For more information on antihistamine use in skin care and psoriasis management, visit the American Academy of Dermatology’s resource on topical antihistamines.

35. Chamomile Extract Creams

Chamomile extract creams are valued for their potent anti-inflammatory and calming effects, making them a gentle option for soothing irritated, itchy, or inflamed psoriatic skin. The extract is rich in natural compounds such as bisabolol, chamazulene, and flavonoids, which have been shown to reduce redness, ease discomfort, and promote the healing of damaged skin. These properties make chamomile a frequent ingredient in over-the-counter creams and ointments formulated for sensitive skin or those prone to allergic reactions.

When compared to calendula, another botanical remedy for skin irritation, chamomile is similarly effective in reducing inflammation and promoting skin comfort. However, chamomile is often considered milder and more suitable for individuals with extremely sensitive skin, while calendula may be preferred for its slightly stronger wound-healing action. Despite its reputation for gentleness, chamomile belongs to the Asteraceae family, and individuals allergic to ragweed or related plants should perform a patch test before widespread use to prevent allergic reactions. For more on chamomile’s benefits and safety in dermatology, visit the National Institutes of Health review on chamomile.

36. Jojoba Oil

Jojoba oil, derived from the seeds of the jojoba plant (Simmondsia chinensis), is widely recognized in skincare for its remarkable similarity to the skin’s own natural sebum. This unique feature allows jojoba oil to absorb easily, hydrate deeply, and help restore the skin’s protective barrier without leaving a greasy residue. For individuals with psoriasis, jojoba oil can help soften thick scales, reduce dryness, and soothe irritation, making it a practical addition to a daily moisturizing routine.

Compared to coconut oil, which is heavier and more likely to leave a lingering film on the skin, jojoba oil is lighter and less likely to clog pores. Its non-comedogenic properties make it especially suitable for facial application and for those prone to acne or folliculitis. Jojoba oil can also be safely used on the scalp, elbows, and knees—common areas for psoriasis plaques—where it helps loosen scales and enhance the efficacy of other topical treatments. When choosing jojoba oil, opt for pure, cold-pressed varieties free from additives. For more information on jojoba oil’s benefits and safe use in psoriasis care, visit the National Psoriasis Foundation’s natural remedies page.

37. Lanolin-Based Creams

Lanolin is a natural, waxy substance extracted from sheep’s wool and is highly valued for its exceptional moisturizing and skin-softening properties. It works by forming an occlusive barrier on the skin, trapping moisture and preventing water loss, which is especially beneficial for individuals with psoriasis who experience persistent dryness and cracking. Lanolin-based creams are often used to soothe rough, scaly patches and support the skin’s healing process, making them a common choice for both daily maintenance and acute flare-ups.

Compared to vegan alternatives such as shea butter, cocoa butter, or plant oils, lanolin provides a uniquely rich texture and long-lasting hydration. However, because it is an animal-derived product, it may not be suitable for those seeking cruelty-free or vegan options. Additionally, some individuals are allergic to wool or have sensitivities to lanolin, which can lead to redness, itching, or rash upon application. It’s important to perform a patch test before using lanolin-based creams, especially if you have a history of wool allergies. For more information on lanolin and alternatives for sensitive skin, see the American Academy of Dermatology’s moisturizing guide.

38. Magnesium Oil Sprays

Magnesium oil sprays are over-the-counter topical products formulated to deliver magnesium chloride directly to the skin. Magnesium is an essential mineral involved in numerous bodily functions, including the regulation of inflammation. Some research suggests that magnesium may help calm inflammatory responses in the skin, making these sprays a popular adjunct for individuals with psoriasis seeking natural options for soothing discomfort and reducing irritation.

Unlike oral magnesium supplements, which are absorbed through the digestive tract, magnesium oil sprays are applied directly to affected areas and absorbed transdermally. While evidence for the efficacy of topical magnesium is still emerging, many users report a reduction in itching and improved skin texture with consistent use. Compared to oral forms, topical magnesium bypasses the gastrointestinal system and may be more suitable for people who experience digestive side effects from supplements. To use, spray onto clean, dry skin and gently massage in. Some individuals may experience a tingling or mild stinging sensation, especially if the skin is cracked; diluting the spray with water or applying over a moisturizer can minimize discomfort. For more on magnesium’s benefits for skin health, see the National Psoriasis Foundation’s overview on magnesium.

39. Sulfur Ointments

Sulfur ointments have a long-standing history in dermatology for treating various skin conditions, including psoriasis. Sulfur acts as a keratolytic and antimicrobial agent—helping to soften and remove thickened scales, reduce inflammation, and prevent infection in compromised skin. Its exfoliating properties make it particularly useful for managing plaques and reducing the buildup of dead skin cells. Sulfur is often found in over-the-counter creams, ointments, and medicated soaps, and may be used alone or in combination with other ingredients.

Compared to salicylic acid, which is another common keratolytic agent, sulfur tends to be slightly milder but can still effectively assist in scale removal and skin smoothing. While salicylic acid primarily targets exfoliation, sulfur’s additional antimicrobial action offers a broader approach to skin care. However, one of the main drawbacks of sulfur ointments is their strong, distinctive odor, which some users find unpleasant and persistent even after washing. To minimize this, apply sulfur ointments at night or choose formulations with odor-masking ingredients. As with all topical treatments, patch test first to check for irritation. For more on sulfur’s use in psoriasis and related skin conditions, visit the American Academy of Dermatology’s resource on sulfur.

40. Hyaluronic Acid Creams

Hyaluronic acid is a naturally occurring molecule renowned for its exceptional ability to retain moisture—holding up to 1,000 times its weight in water. In over-the-counter creams, hyaluronic acid acts as a powerful humectant, drawing moisture into the outer skin layers and maintaining hydration throughout the day. This makes it especially beneficial for individuals with psoriasis, whose skin is often prone to dryness, flaking, and a compromised barrier function.

When compared to glycerin, another popular humectant, hyaluronic acid offers a lighter, non-greasy feel while delivering comparable or even superior hydration. Both ingredients can improve skin softness and elasticity, but hyaluronic acid is often preferred for its ability to plump the skin and reduce surface roughness without clogging pores. For optimal results, apply hyaluronic acid creams to slightly damp skin after cleansing or bathing, then follow with a heavier moisturizer or ointment to lock in the added hydration. This layering technique maximizes moisture retention and supports the skin’s barrier. For more on hyaluronic acid’s role in skin care, see the National Psoriasis Foundation’s guide to hyaluronic acid.

41. Probiotic Skincare

Probiotic skincare is an emerging field focused on supporting a healthy skin microbiome—the community of beneficial bacteria that live on the skin’s surface. New research suggests that a balanced microbiome can help regulate inflammation, protect against harmful pathogens, and potentially improve chronic skin conditions like psoriasis. Topical probiotic creams and lotions introduce live or lysed beneficial bacteria to the skin, which may help restore microbial harmony and reduce flare-ups linked to bacterial imbalance.

Compared to oral probiotics, which are designed to support gut health and systemic immunity, probiotic skincare targets the skin’s surface directly. While oral probiotics have shown some promise in reducing the severity of psoriasis for certain individuals, topical products may provide more immediate and localized benefits for skin barrier function and inflammation. Probiotic skincare can be considered as a supplement to standard treatments, especially for those with sensitive skin or a history of frequent infections. However, as this field is still developing, it’s best to use products from reputable brands and consult a dermatologist before beginning a new regimen. For more information on the science behind probiotics and skin health, visit the National Psoriasis Foundation’s resource on probiotics.

42. Ointments with Colloidal Silver

Ointments containing colloidal silver are marketed for their purported antibacterial, antifungal, and wound-healing effects. Some manufacturers claim that colloidal silver can help reduce infection risk and soothe inflamed skin, leading certain individuals with psoriasis to try these products for relief from irritation or secondary infections. However, these claims are not strongly supported by scientific evidence, and the use of colloidal silver in topical and oral forms remains highly controversial in dermatology and general healthcare.

There are significant safety concerns associated with colloidal silver. Prolonged use can result in argyria—an irreversible bluish-gray discoloration of the skin—and may pose other health risks if absorbed systemically. Due to these concerns, regulatory agencies such as the U.S. Food and Drug Administration (FDA) have not approved colloidal silver for the treatment of any medical condition, including psoriasis. The FDA specifically warns against the use of colloidal silver in over-the-counter health products. Individuals considering ointments with colloidal silver should exercise caution and consult a healthcare provider before use. For more on safety and regulations regarding colloidal silver, refer to the FDA’s consumer update on colloidal silver.

43. Turmeric Creams

Turmeric creams are gaining traction in psoriasis care due to the anti-inflammatory properties of curcumin, turmeric’s primary active compound. Curcumin has been shown in research to modulate inflammatory pathways, potentially alleviating redness, swelling, and discomfort associated with psoriasis plaques. When used topically, turmeric creams deliver curcumin directly to affected skin, offering a localized approach to managing mild symptoms and supporting the skin’s natural healing processes.

Compared to oral turmeric supplements, which are absorbed systemically and may interact with medications or gastrointestinal health, topical turmeric allows for targeted application with a lower risk of systemic side effects. While the bioavailability of curcumin through the skin is still being studied, many users report improvement in skin comfort and appearance with consistent use. To avoid staining skin or clothing—a common concern with turmeric—opt for creams formulated for cosmetic use rather than pure turmeric paste. Always patch test new products to check for potential allergies or irritation. For more on the research and application of turmeric in psoriasis, see the National Psoriasis Foundation’s resource on turmeric.

44. Licorice Root Extract

Licorice root extract, derived from the Glycyrrhiza glabra plant, is valued in dermatology for its anti-inflammatory and anti-itch properties. The active compound glycyrrhizin is known to help reduce redness, calm irritation, and soothe itching, making licorice extract a promising option for individuals with psoriasis who seek natural alternatives to conventional anti-itch treatments. Topical licorice creams are often included in over-the-counter products targeting sensitive or inflamed skin.

When compared to antihistamine creams, which block histamine signals to temporarily relieve itching, licorice root extract works by modulating inflammatory pathways and supporting the skin’s natural healing processes. While both can be effective for short-term relief, licorice extract offers a plant-based option with a lower risk of drowsiness or systemic side effects. However, as with any botanical product, there is a risk of allergic reaction. Signs of sensitivity include redness, swelling, rash, or increased itching at the application site. Always perform a patch test on a small area of skin before applying licorice creams more widely. For more information on licorice root extract and its uses in skin care, visit the National Institutes of Health review on licorice in dermatology.

45. Grapeseed Oil

Grapeseed oil is a lightweight, non-greasy moisturizer derived from the seeds of grapes, making it an appealing option for individuals with psoriasis who prefer a fast-absorbing oil. This oil is rich in linoleic acid, an essential fatty acid that helps maintain the skin’s natural barrier and prevent moisture loss. Its light texture allows for easy application without leaving a heavy residue, which distinguishes it from heavier oils such as coconut or olive oil that may feel occlusive or sticky, especially on large body areas.

In addition to its moisturizing effects, grapeseed oil is packed with antioxidants, particularly vitamin E and polyphenols, which can help protect the skin from oxidative stress and support skin repair. These antioxidants may also contribute to reducing inflammation and promoting a healthier skin appearance. Grapeseed oil is suitable for use on both the body and scalp, and it can be layered under thicker creams or ointments for enhanced hydration. As with any new skincare product, it’s wise to perform a patch test to rule out sensitivity. For more information on the benefits of grapeseed oil in dermatology, see the National Institutes of Health review on plant oils in skin care.

46. Argan Oil

Argan oil, extracted from the kernels of the Moroccan argan tree, is highly valued for its rich content of essential fatty acids—especially oleic and linoleic acids—as well as vitamin E and potent antioxidants. These nutrients make argan oil an effective emollient for softening and hydrating dry, flaky skin common in psoriasis. Its lightweight, easily absorbed texture allows it to moisturize without clogging pores or leaving a greasy residue, making it suitable for daily use.

When compared to avocado oil, both oils offer significant moisturizing and skin-soothing benefits, but argan oil is generally lighter in feel and less likely to contribute to breakouts on acne-prone or sensitive skin. Avocado oil, with its thicker consistency and higher vitamin content, may be better suited for stubborn, thick plaques, while argan oil excels as an all-purpose hydrator for both skin and hair. Argan oil’s popularity in hair and scalp products also makes it a convenient choice for managing scalp psoriasis, helping to reduce scaling and improve shine without weighing hair down. For more information on argan oil’s dermatological benefits, visit the National Institutes of Health review on botanical oils.

47. Sunflower Oil

Sunflower oil, derived from the seeds of the sunflower plant, is rich in linoleic acid—an essential fatty acid known for its ability to reinforce the skin’s barrier and reduce water loss. This barrier support is particularly important for individuals with psoriasis, as flare-ups often cause increased transepidermal water loss and a compromised skin barrier. Sunflower oil’s lightweight, non-greasy texture makes it easily absorbed, providing soothing hydration without clogging pores or leaving behind residue.

Compared to olive oil, which is heavier and higher in oleic acid, sunflower oil is generally less likely to irritate sensitive or inflamed skin. Olive oil can be beneficial for some, but its thick consistency may exacerbate scaling or block pores in others. Sunflower oil is a gentle choice for daily moisturization or as a calming treatment during flare-ups, particularly when applied immediately after bathing. It can also be layered under heavier ointments for added barrier protection. For more scientific insight on sunflower oil’s dermatological use and its benefits for inflammatory skin conditions, visit the National Institutes of Health review on plant oils in skin care.

48. Manuka Honey Creams

Manuka honey, produced by bees that pollinate the Manuka bush in New Zealand, is renowned for its potent antimicrobial and wound-healing properties. Unlike regular honey, Manuka honey contains high levels of methylglyoxal, a compound responsible for its superior antibacterial effectiveness. In over-the-counter creams, Manuka honey is used to help reduce inflammation, prevent infection in cracked or open psoriatic plaques, and promote faster skin healing. Its natural humectant properties also aid in retaining moisture, making it especially beneficial for dry, compromised skin.

Compared to regular honey, Manuka honey’s greater antibacterial activity makes it a preferred choice for skin conditions prone to infection or slow healing. However, not all products labeled as “Manuka” offer the same potency, so it’s important to choose creams that specify a Unique Manuka Factor (UMF) rating for authenticity. When using Manuka honey creams, always patch test first to rule out allergic reactions, particularly for those with bee or pollen allergies. Avoid applying honey to large areas of broken skin or in individuals with diabetes without consulting a healthcare provider. For more on Manuka honey’s dermatological applications, visit the National Institutes of Health review on honey in wound care.

49. Silicone Gel Sheets

Silicone gel sheets are specialized over-the-counter products originally designed for scar management, but they are increasingly used to help smooth thick, stubborn plaques in psoriasis. Silicone acts as an occlusive barrier, creating a moist healing environment that can soften and flatten raised skin over time. This effect is particularly beneficial for individuals who struggle with persistent plaques that are resistant to creams or ointments. By limiting water loss and protecting the skin from external irritants, silicone sheets can also reduce itching and discomfort.

Compared to occlusive ointments like petroleum jelly, silicone gel sheets provide targeted, sustained contact with affected areas, making them ideal for localized plaques on the elbows, knees, or other small regions. They are easy to apply, reusable, and less messy than thick ointments, which may transfer to clothing or bedding. To use, cleanse and dry the skin before placing the silicone sheet over the plaque, wearing it for several hours or overnight as recommended by the manufacturer. For optimal results, combine with a gentle moisturizing routine. For more on silicone’s dermatological uses, visit the National Institutes of Health review on silicone gel sheeting.

50. Non-Prescription Topical Retinoids

Non-prescription topical retinoids, such as those containing retinol or retinaldehyde, are increasingly available in over-the-counter skincare products for psoriasis. Retinoids are derivatives of vitamin A and work by normalizing skin cell turnover—helping to prevent the buildup of thick, scaly plaques that are characteristic of psoriasis. By promoting exfoliation and encouraging new cell growth, retinoids can improve skin texture and reduce scaling, although their effects are typically milder than those of prescription-strength formulations like tazarotene.

Compared to prescription retinoids, OTC products are less potent, which reduces the risk of severe side effects but also means results may be more gradual and subtle. Common side effects include dryness, redness, peeling, and increased sensitivity to sunlight, especially during the initial weeks of use. To minimize irritation, start with a lower concentration and apply every other night, gradually increasing usage as tolerated. Always use sunscreen during the day, as retinoids can heighten sun sensitivity. Individuals with sensitive skin or active flare-ups should consult a dermatologist before starting retinoid therapy. For additional details on retinoids and their role in psoriasis care, visit the National Psoriasis Foundation’s resource on retinoids.

Conclusion

Early and consistent use of over-the-counter treatments plays a crucial role in managing psoriasis symptoms, improving comfort, and preserving skin health. With a wide array of OTC options—from gentle moisturizers and emollient oils to keratolytic agents and innovative natural remedies—individuals can tailor their care to their unique needs and preferences. However, not all cases respond to non-prescription solutions alone. If symptoms persist, worsen, or significantly impact quality of life, it is essential to seek guidance from a healthcare provider or dermatologist. Professional support ensures accurate diagnosis and access to advanced therapies when needed. For more information and expert advice, visit the National Psoriasis Foundation.

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