Chronic Fatigue Causes Doctors Keep Missing

1. Sleep Apnea

Sleep apnea is a common yet frequently missed cause of chronic fatigue. This condition occurs when breathing repeatedly stops and starts during sleep, leading to brief drops in blood oxygen levels. These interruptions, often lasting only seconds, can happen dozens or even hundreds of times each night. As a result, the brain and body are repeatedly jolted out of deep, restorative sleep—without the person realizing it.

One reason sleep apnea is so often overlooked is its subtle presentation. Many people with sleep apnea do not report noticeable awakenings, and their main complaint is persistent daytime tiredness or difficulty concentrating. Classic symptoms like loud snoring or gasping for air may not be present, especially in women and younger individuals. Consequently, doctors may attribute ongoing fatigue to stress, poor sleep habits, or mood disorders instead.

Research from the Sleep Foundation and Mayo Clinic highlights how untreated sleep apnea can significantly impair cognitive function, mood, and quality of life. Because of its hidden nature, sleep apnea remains a root cause of fatigue that doctors often miss, particularly when patients do not fit the stereotypical profile.

2. Iron Deficiency Without Anemia

Iron is essential for energy production and oxygen transport in the body, but many people suffer from iron deficiency even when their blood counts remain within normal limits. This condition, known as iron deficiency without anemia, can significantly impact energy and cognitive function, particularly in women of childbearing age and vegetarians, who are at higher risk for low iron stores.

Standard blood tests typically assess hemoglobin or hematocrit levels to check for anemia. However, these do not always detect suboptimal iron status. Ferritin, a marker of the body’s iron storage, may be low even when anemia is absent, leading to ongoing fatigue and weakness. If doctors only order basic blood counts, they may overlook iron deficiency as a culprit for chronic tiredness.

According to the American Society of Hematology and Harvard Health, iron deficiency can cause symptoms such as brain fog, restless legs, and irritability, even before anemia develops. Addressing this subtle form of deficiency often brings substantial relief, but it requires a careful and comprehensive approach to testing.

3. Thyroid Dysfunction

Thyroid hormones play a pivotal role in regulating the body’s energy metabolism. Even mild thyroid dysfunction—whether hypothyroidism (underactive thyroid) or hyperthyroidism (overactive thyroid)—can manifest as persistent fatigue, yet these conditions often go undetected when symptoms are subtle.

Mild hypothyroidism may present with vague complaints such as low energy, feeling cold, dry skin, or mild weight gain. Conversely, early hyperthyroidism can cause irritability, insomnia, or unexplained weight loss, sometimes without the classic symptoms like palpitations or heat intolerance. Real-world cases frequently reveal patients experiencing months or years of unexplained tiredness, only to discover minor abnormalities in thyroid function after comprehensive testing.

Doctors may miss early thyroid dysfunction because standard screening often relies on TSH (thyroid-stimulating hormone) levels alone. However, The Endocrine Society and Mayo Clinic note that subtle cases may require measuring free T4, free T3, and thyroid antibodies for accurate diagnosis. Without a high index of suspicion, thyroid-related fatigue can be missed, prolonging a patient’s search for answers.

4. Vitamin B12 Deficiency

Vitamin B12 is crucial for maintaining healthy nerves and producing red blood cells. A deficiency can develop gradually, especially in older adults who absorb nutrients less efficiently, or in vegans and vegetarians, whose diets may lack sufficient B12 sources. The insidious onset means symptoms often creep in unnoticed, making it easy for both patients and doctors to overlook this deficiency as a cause of persistent fatigue.

Early symptoms include tiredness, weakness, and difficulty concentrating. As the deficiency progresses, individuals may experience numbness or tingling in the hands and feet, balance problems, and even mood changes like depression or irritability. These issues can mimic other conditions, leading to misdiagnosis or delayed treatment. Routine blood tests may not always flag B12 deficiency until it becomes severe, which is why at-risk groups should be screened proactively.

According to the National Institutes of Health and Mayo Clinic, early recognition and treatment of vitamin B12 deficiency can reverse symptoms and prevent irreversible nerve damage. Watching for subtle signs and seeking prompt evaluation is especially important for those in high-risk categories.

5. Hidden Infections (e.g., EBV, Lyme)

Some infections linger in the body long after the initial illness has passed, triggering chronic fatigue that baffles both patients and healthcare providers. The Epstein-Barr virus (EBV), responsible for mononucleosis, is a classic example. Even after the acute phase resolves, EBV can remain dormant and periodically reactivate, leading to ongoing exhaustion, brain fog, and muscle aches.

Lyme disease is another hidden culprit. Caused by the bacterium Borrelia burgdorferi and transmitted by ticks, Lyme can transition into a persistent state where symptoms such as fatigue, joint pain, and cognitive difficulties persist for months or years. These lingering symptoms, sometimes called “post-treatment Lyme disease syndrome,” often escape detection, especially when the characteristic bull’s-eye rash or history of tick bite is absent.

According to the CDC on Epstein-Barr virus and the CDC on post-Lyme disease symptoms, these infections are frequently missed because standard blood tests may not detect chronic or reactivated infections. Recognizing the potential for hidden infections and conducting targeted testing is essential for uncovering these elusive sources of persistent fatigue.

6. Medication Side Effects

Many people experience chronic fatigue as a side effect of medications they take daily—yet this possibility is often overlooked during routine checkups. A wide array of common drugs, including antihistamines, blood pressure medications (such as beta-blockers), antidepressants, and even some pain relievers, can all contribute to ongoing tiredness, brain fog, or sluggishness.

Antihistamines, frequently used for allergies, are notorious for causing drowsiness, especially older “first-generation” types. Beta-blockers and certain calcium channel blockers, prescribed for high blood pressure or heart issues, may suppress heart rate and lower energy levels. Even medications intended to improve mood or manage anxiety, like selective serotonin reuptake inhibitors (SSRIs), can have fatigue as a side effect for some individuals.

According to the CDC and the Mayo Clinic, patients and doctors alike may miss these connections, particularly when symptoms develop gradually or are attributed to underlying health conditions. Reviewing all current medications with a healthcare provider—and considering possible alternatives—can provide relief and restore lost energy.

7. Depression and Hidden Mood Disorders

Depression and other mood disorders are tightly linked to chronic fatigue, but their role is frequently minimized or misunderstood. Many people experience exhaustion, poor concentration, and a lack of motivation as primary symptoms of depression, often without classic signs like persistent sadness. These symptoms can be mistaken for “normal” stress, aging, or simply a busy lifestyle—causing both patients and doctors to overlook the underlying mood disorder.

Hidden mood disorders such as dysthymia (persistent mild depression) or even atypical depression can manifest predominantly as fatigue, irritability, or trouble sleeping. Because the tiredness associated with depression tends to be constant and unrelenting, it may not improve with rest or changes in routine. This makes it especially challenging to identify, particularly in older adults or those with demanding lives.

The National Institute of Mental Health and CDC emphasize the importance of considering mood and mental health when evaluating chronic fatigue. Open conversations about emotional well-being and screening for depression can uncover a treatable cause of long-standing tiredness that might otherwise be dismissed.

8. Autoimmune Diseases (e.g., Lupus, RA)

Autoimmune diseases occur when the immune system mistakenly attacks healthy tissues, leading to chronic inflammation and often profound fatigue. Conditions such as lupus (systemic lupus erythematosus) and rheumatoid arthritis (RA) are prime examples. In these disorders, immune system overactivity can slowly wear down the body even before joint pain or rashes appear, making diagnosis challenging in the early stages.

Patients may experience long-standing, unexplained tiredness, low-grade fevers, or vague aches. Because these symptoms are non-specific, doctors may initially attribute them to stress, aging, or viral infections. Sometimes, subtle signs like mild joint stiffness or hair thinning are overlooked, delaying the recognition of an underlying autoimmune process.

According to the CDC on lupus and the Arthritis Foundation, early detection is critical for preventing organ damage and improving quality of life. Comprehensive evaluation—including autoimmune blood markers and a detailed symptom history—is necessary when chronic fatigue is present without another obvious cause. Recognizing the subtle beginnings of autoimmune disease can bring much-needed answers to those who feel persistently worn out.

9. Diabetes (Especially Type 2, Early Stages)

Diabetes, particularly type 2 in its early stages, is a frequently missed cause of chronic fatigue. Even before the hallmark symptoms of frequent urination, excessive thirst, or blurred vision appear, mild blood sugar imbalances can disrupt energy production at the cellular level. Fluctuating glucose levels cause the body’s cells to struggle to access the fuel they need, resulting in persistent tiredness and sluggishness.

Many individuals with early or prediabetes don’t realize their blood sugar levels are elevated. Fatigue may be the only sign, often attributed to aging, poor sleep, or stress. Because routine blood work may not always include fasting glucose or A1C tests, subtle changes in blood sugar can go undetected for years. This delay in diagnosis increases the risk of complications and can prolong unnecessary suffering.

The CDC and Mayo Clinic emphasize the importance of early detection, which allows for lifestyle changes and intervention to prevent progression. Anyone experiencing ongoing fatigue—especially those with risk factors like obesity or family history—should request comprehensive screening for blood sugar issues.

10. Chronic Kidney Disease

Chronic kidney disease (CKD) is a stealthy contributor to chronic fatigue that often escapes detection in its early stages. When kidney function declines, the body’s ability to filter waste and excess fluids becomes impaired. Even mild reductions in kidney performance can result in the accumulation of toxins in the bloodstream, leading to persistent tiredness, mental cloudiness, and general malaise long before more obvious symptoms appear.

Fatigue associated with CKD is frequently dismissed or attributed to aging, stress, or other chronic conditions. Early on, there may be no swelling, changes in urination, or high blood pressure—signs that would otherwise trigger suspicion of kidney issues. This makes routine blood work, including measurements of creatinine and estimated glomerular filtration rate (eGFR), especially important for early detection.

The National Kidney Foundation and CDC note that early diagnosis allows for interventions that slow disease progression and improve quality of life. If you or someone you know is dealing with unexplained fatigue, it’s crucial to consider kidney health as a potential underlying cause.

11. Heart Failure (Mild or Early Stages)

Heart failure isn’t always dramatic—especially in its mild or early stages. Subtle inefficiency in the heart’s ability to pump blood can first appear as lingering fatigue, particularly among older adults. When the heart cannot circulate oxygen-rich blood effectively, the body’s tissues and organs receive less energy, making everyday activities feel exhausting even before noticeable shortness of breath or swelling emerges.

Early signs are often vague: individuals may report reduced stamina, an unusual need for rest, or difficulty with physical exertion they once handled with ease. Because these symptoms can be gradual and easily mistaken for aging or inactivity, healthcare providers may overlook the possibility of early heart failure, especially without classic features like leg swelling or chest discomfort.

According to the American Heart Association and CDC, early diagnosis is crucial for effective treatment and slowing disease progression. If persistent fatigue is present—especially in those with risk factors such as high blood pressure or a history of heart disease—considering subtle cardiac causes can be life-changing.

12. Celiac Disease and Gluten Sensitivity

Celiac disease and non-celiac gluten sensitivity are increasingly recognized as underappreciated causes of chronic fatigue. In people with celiac disease, ingesting gluten triggers an autoimmune response that damages the lining of the small intestine. This damage impairs the absorption of vital nutrients such as iron, B vitamins, and magnesium, all of which are crucial for maintaining energy levels. Ongoing inflammation further saps the body’s reserves, leaving individuals feeling persistently tired and drained.

Not everyone with gluten intolerance experiences classic digestive symptoms like diarrhea or bloating. In fact, many people—especially adults—may present primarily with fatigue, headaches, or mood changes. This subtle presentation can delay diagnosis for years, as both patients and doctors attribute symptoms to stress, busy lifestyles, or unrelated health issues.

The Celiac Disease Foundation and Mayo Clinic stress that early identification and a strict gluten-free diet can dramatically improve symptoms and restore energy. If unexplained fatigue persists, especially with a family history of celiac disease or related autoimmune disorders, consider comprehensive testing for gluten-related conditions.

13. Chronic Fatigue Syndrome (CFS/ME)

Chronic Fatigue Syndrome, also known as myalgic encephalomyelitis (CFS/ME), is one of the most perplexing and frequently missed causes of relentless tiredness. This disorder is characterized by profound, disabling fatigue that does not improve with rest and is often worsened by physical or mental activity. The fatigue associated with CFS/ME is distinct from ordinary tiredness—it can be so severe that daily tasks become nearly impossible.

Diagnosing CFS/ME is challenging because there are no definitive tests or biomarkers. Physicians must rely on a thorough medical history and exclusion of other possible causes. Symptoms often include unrefreshing sleep, cognitive difficulties (“brain fog”), muscle or joint pain, and sometimes sore throat or tender lymph nodes. Unfortunately, because the symptoms overlap with many other conditions and may be dismissed as psychological, patients often endure years of medical uncertainty or skepticism.

According to the CDC and the National Institute of Neurological Disorders and Stroke, awareness of CFS/ME is growing, but many cases still go unrecognized. Early identification and supportive care are essential to improving quality of life for those affected.

14. Undiagnosed Food Allergies

Undiagnosed food allergies and subtle food sensitivities can be surprising contributors to persistent fatigue. Unlike immediate, dramatic allergic reactions, mild sensitivities often trigger low-grade immune responses that drain the body’s energy over time. The immune system’s ongoing efforts to combat perceived threats can result in a constant feeling of tiredness, brain fog, and difficulty concentrating.

Common culprits include dairy, eggs, soy, nuts, and wheat. Symptoms may be elusive—such as headaches, digestive discomfort, or even joint pain—making it easy to miss the dietary connection. In some cases, individuals experience an afternoon energy slump or feel particularly tired after meals, which are important red flags. Because these effects are often delayed and non-specific, food-related fatigue is frequently overlooked by both patients and healthcare providers.

The American Academy of Allergy, Asthma & Immunology and Cleveland Clinic recommend keeping a detailed food and symptom diary to help identify potential triggers. Consulting an allergist or immunologist can lead to targeted testing and dietary adjustments, offering significant relief for those suffering from unexplained chronic fatigue.

15. Adrenal Insufficiency

Adrenal insufficiency is a lesser-known but important cause of chronic fatigue that can easily slip under the radar. The adrenal glands produce hormones—like cortisol and aldosterone—that are vital for the body’s stress response, blood pressure regulation, and energy metabolism. When these glands underperform, the body struggles to cope with everyday stressors, resulting in ongoing tiredness, weakness, and sometimes dizziness or salt cravings.

Fatigue from adrenal insufficiency often builds gradually and may be confused with depression, anxiety, or simply the effects of a hectic lifestyle. Other subtle symptoms include muscle aches, weight loss, low blood pressure, and gastrointestinal upset. Because these signs are non-specific, doctors may initially attribute them to psychological causes or overlook adrenal testing altogether.

According to the Endocrine Society and Mayo Clinic, diagnosis requires careful hormone evaluation and sometimes an ACTH stimulation test. Awareness of adrenal insufficiency is key—especially in those with unexplained, unrelenting fatigue—so that proper treatment can restore energy and prevent more serious complications.

16. Perimenopause and Menopause

Perimenopause and menopause bring profound hormonal shifts that can dramatically impact a woman’s energy levels. As estrogen and progesterone levels decline, many women experience persistent fatigue that may develop even before hot flashes or irregular periods emerge. These changes can disrupt sleep, worsen mood, and cause muscle aches, all contributing to a sense of unrelenting tiredness.

Because symptoms often appear gradually and overlap with normal aging, perimenopausal fatigue is frequently dismissed or overlooked by healthcare providers. Women may be told their tiredness is “just getting older” or due to life stress, missing the opportunity to address an underlying hormonal cause. Other common signs—such as night sweats, anxiety, or difficulty concentrating—can further muddy the clinical picture.

The National Institute on Aging and Mayo Clinic emphasize that targeted support, such as lifestyle changes or hormone therapy, can alleviate symptoms and restore vitality. Recognizing the link between hormonal changes and chronic fatigue is essential for women navigating this natural life transition.

17. Chronic Liver Disease

The liver is a powerhouse organ, responsible for detoxifying the blood, regulating metabolism, and storing essential nutrients. Even mild dysfunction in the liver can disrupt these critical processes, resulting in persistent tiredness that often goes unexplained. Chronic liver diseases—such as nonalcoholic fatty liver disease, hepatitis, or early-stage cirrhosis—may develop silently, with fatigue being one of the first and most common symptoms.

Because liver disease often progresses gradually, individuals may not notice other signs like jaundice, abdominal pain, or swelling until the condition is advanced. Subtle liver dysfunction can lead to a buildup of toxins, impaired energy production, and low-grade inflammation, all of which sap the body’s vitality. Fatigue is frequently misattributed to lifestyle, aging, or stress, making it easy to overlook the liver’s involvement.

The American Liver Foundation and CDC stress the importance of early diagnosis and lifestyle interventions to prevent progression and improve energy levels. If unexplained tiredness persists, simple blood tests for liver enzymes can help reveal hidden dysfunction.

18. Undiagnosed Cancer (Especially Blood Cancers)

Cancer is a word that sparks fear, yet its earliest signs are often subtle and nonspecific. Blood cancers such as leukemia, lymphoma, or multiple myeloma frequently present with unexplained, persistent fatigue as their first and only symptom for weeks or months. This tiredness is often profound and not relieved by rest, differing markedly from ordinary exhaustion.

The reason for this fatigue is complex: cancer can disrupt normal blood cell production, cause chronic inflammation, and sap the body’s energy reserves as it grows. Additional warning signs—such as easy bruising, frequent infections, night sweats, or unexplained weight loss—may develop later, but are often absent in the beginning. Because persistent tiredness has many common causes, vigilance is required to avoid missing a serious underlying problem.

The American Cancer Society and Leukemia & Lymphoma Society recommend that unexplained fatigue lasting more than a few weeks, especially when accompanied by other subtle symptoms, should prompt a thorough medical evaluation. Early detection is key to better outcomes and successful treatment.

19. Fibromyalgia

Fibromyalgia is a chronic disorder characterized by widespread pain, persistent fatigue, and cognitive difficulties. Despite affecting millions of people, this syndrome is often misunderstood or misattributed to psychological causes, leading to years of frustration for those seeking answers. Fatigue in fibromyalgia can be overwhelming, with sufferers frequently describing it as “energy-draining” and unrelieved by sleep. The condition may also involve sleep disturbances, headaches, irritable bowel symptoms, and “fibro fog”—a term for the memory lapses and concentration issues that often accompany the pain and exhaustion.

Because laboratory tests and imaging studies are usually normal, diagnosis relies on a careful assessment of symptoms and exclusion of other conditions. Unfortunately, this means patients are sometimes told their symptoms are “all in their head,” which can delay effective management and erode trust in healthcare.

According to the CDC and the American College of Rheumatology, recognizing fibromyalgia as a legitimate medical condition is essential. With proper diagnosis and a multidisciplinary approach—including medication, exercise, and cognitive therapy—many people experience significant improvement in both fatigue and pain.

20. Obstructive Nasal Conditions

Chronic nasal congestion, nasal polyps, and allergies are more than minor nuisances—they can be significant contributors to ongoing fatigue. When the nasal passages are blocked due to inflammation, polyps, or allergic reactions, breathing through the nose becomes difficult, especially at night. This leads to poor sleep quality, frequent awakenings, and even mouth breathing, all of which disrupt the body’s restorative processes and leave individuals feeling tired throughout the day.

Conditions such as allergic rhinitis and chronic sinusitis can cause subtle but persistent sleep fragmentation, even when a person believes they’ve slept enough hours. Over time, this sleep deficit accumulates, resulting in excessive daytime sleepiness, headaches, difficulty concentrating, and low energy. Because nasal symptoms may fluctuate or seem mild, both patients and doctors can underestimate their impact on overall well-being.

The American Academy of Otolaryngology-Head and Neck Surgery and the CDC highlight the importance of addressing nasal obstruction to improve sleep quality and, by extension, energy levels. Effective treatments—including allergy management, nasal steroids, or surgery for polyps—can restore restful sleep and relieve chronic fatigue.

21. Chronic Migraine

Chronic migraine is often thought of as a condition marked solely by intense headaches, but its impact extends far beyond pain. For many, migraines involve recurring episodes of exhaustion, brain fog, and sensitivity to light or sound that can last for days—even when headache pain is mild or absent. These symptoms may present as “silent migraines” or migraine variants, making them harder to recognize and diagnose.

The ongoing neurological disruption caused by frequent migraines can sap a person’s physical and mental energy, leading to missed work, social withdrawal, and diminished quality of life. Fatigue can persist between attacks, with individuals feeling as if they’re never fully recovered. In some cases, the fatigue and cognitive challenges are more debilitating than the pain itself.

According to the American Migraine Foundation and the Mayo Clinic, chronic migraine can affect sleep, mood, and concentration, further compounding exhaustion. Recognizing migraine as a source of ongoing fatigue—especially in the absence of classic headache symptoms—can lead to more effective management and a better quality of life.

22. Post-Viral Fatigue (e.g., After COVID-19)

Many people experience lingering fatigue after recovering from viral illnesses—a phenomenon now familiar to millions affected by COVID-19. Post-viral fatigue can persist for weeks or months after the infection has cleared, leaving individuals feeling drained, foggy, and unable to bounce back to their usual energy levels. This syndrome is not unique to COVID-19; other viruses like influenza, Epstein-Barr, and cytomegalovirus can also trigger lasting tiredness.

With COVID-19, a significant number of “long-haulers” report ongoing exhaustion, muscle weakness, and difficulty concentrating—sometimes long after mild or moderate initial symptoms have resolved. The underlying causes are still being studied, but immune system changes, inflammation, and disruptions in autonomic function are believed to play a role. The unpredictability and duration of post-viral fatigue can be distressing, especially for those accustomed to being active and healthy.

The CDC and World Health Organization stress that post-viral fatigue is a real and significant issue. Recovery may require pacing, lifestyle adjustments, and support from healthcare providers. Recognizing this syndrome is crucial for validating patient experiences and guiding appropriate care.

23. Chronic Stress and Burnout

In today’s fast-paced world, chronic stress and burnout are widespread but often unrecognized causes of persistent fatigue. Ongoing psychological or occupational stress forces the body’s stress response system—particularly the adrenal glands—to work overtime, leading to eventual exhaustion and what some refer to as “adrenal fatigue.” While not a formally recognized medical diagnosis, this pattern describes a state where prolonged stress disrupts cortisol production and leaves individuals feeling completely depleted.

Burnout is especially common among busy adults juggling multiple responsibilities. The fatigue associated with chronic stress can manifest as physical tiredness, emotional numbness, insomnia, headaches, and difficulty concentrating. Because these symptoms evolve gradually, they are often dismissed as a normal part of modern life, preventing many people from seeking help until exhaustion becomes overwhelming.

The American Psychological Association and the Mayo Clinic highlight the importance of recognizing and addressing chronic stress before it erodes physical and mental health. Effective interventions—such as stress management techniques, boundaries, and support systems—are essential for reversing fatigue and protecting long-term well-being.

24. Poor Sleep Hygiene

Poor sleep hygiene is one of the most common—and most easily overlooked—causes of chronic tiredness. Irregular sleep schedules, excessive screen time before bed, and exposure to artificial light can disrupt the body’s natural circadian rhythm, making it difficult to fall asleep and stay asleep. Even small deviations, such as inconsistent bedtimes or frequent use of electronic devices late at night, can accumulate and leave you feeling exhausted day after day.

Bright screens from phones, tablets, and computers emit blue light that interferes with melatonin production, the hormone responsible for regulating sleep. Inadequate wind-down routines, caffeine use in the evening, or a noisy bedroom environment further undermine restful sleep. Many people underestimate the cumulative impact of these habits, attributing their fatigue to other factors instead of addressing their sleep environment and behaviors.

Resources from the Sleep Foundation and CDC emphasize the importance of consistent sleep routines, limiting screen time before bed, and optimizing your sleep environment. Simple changes can make a profound difference in energy, mood, and overall health.

25. Restless Legs Syndrome

Restless Legs Syndrome (RLS) is a neurological disorder that often goes undiagnosed, yet it can have a profound impact on sleep quality and daytime energy. People with RLS experience uncomfortable sensations in their legs—described as creeping, crawling, tingling, or aching—especially in the evenings or when lying down. The urge to move the legs to relieve these sensations disrupts the transition into restful sleep and can cause frequent nighttime awakenings.

This continual sleep disruption often leads to chronic fatigue, difficulty concentrating, mood changes, and decreased productivity the following day. RLS can be mistaken for anxiety, insomnia, or even growing pains in children, delaying appropriate diagnosis and treatment. The exact cause isn’t always clear, but iron deficiency, pregnancy, and certain chronic diseases increase the risk.

According to the National Institute of Neurological Disorders and Stroke and the Sleep Foundation, effective management may include lifestyle changes, iron supplementation, and medications. Recognizing RLS as a source of persistent tiredness is essential for restoring healthy sleep and daytime alertness.

26. Dehydration

Dehydration is a surprisingly common and underestimated cause of chronic fatigue. Even mild fluid loss can impair both physical and mental performance, leaving you feeling sluggish, unfocused, and generally worn out. Athletes often recognize the effects of dehydration—reduced endurance, muscle cramps, and delayed recovery—but busy professionals and everyday individuals can be just as vulnerable, especially if they forget to drink water throughout the day.

Fatigue from dehydration can develop subtly, sometimes without the classic signs of thirst. Early symptoms may include headache, dizziness, dry mouth, and dark urine, but energy levels may dip long before these become obvious. Office workers, teachers, healthcare professionals, and anyone spending hours in air-conditioned environments or on their feet are at risk, as are those who rely on coffee or caffeinated drinks, which can further dehydrate the body.

According to the CDC and the Harvard Health Publishing, drinking enough water is key to maintaining optimal energy and cognitive sharpness. Simple strategies—like carrying a water bottle and setting reminders—can help prevent dehydration-related tiredness and boost overall vitality.

27. Chronic Pain Conditions

Chronic pain—whether from arthritis, back problems, migraines, or other long-standing conditions—can be a major drain on both sleep and daytime energy. The body’s ongoing battle with pain activates stress hormones, disrupts restorative sleep cycles, and leaves individuals feeling both physically and mentally depleted. Many people with chronic pain find it difficult to fall or stay asleep, leading to a vicious cycle of exhaustion and increased pain sensitivity.

Conditions such as osteoarthritis, degenerative disc disease, or neuropathic pain often cause micro-awakenings during the night, even if the person doesn’t remember waking up. This sleep fragmentation undermines the quality of rest and prevents the body from fully repairing itself. As fatigue builds, coping with pain becomes even more challenging, affecting mood, motivation, and overall quality of life.

According to the CDC and the Arthritis Foundation, effective pain management and sleep support are essential for breaking this cycle. Approaches may include medication, physical therapy, cognitive-behavioral therapy, and lifestyle changes to help restore energy and improve daily functioning.

28. Anemia (Other Than Iron Deficiency)

Anemia isn’t always the result of iron deficiency—other nutritional shortfalls can also lead to persistent tiredness. Folate deficiency and vitamin B12 deficiency are two common causes of non-iron-related anemia, each impairing the body’s ability to produce healthy red blood cells. Without enough red blood cells to transport oxygen, vital organs and muscles are starved of energy, resulting in ongoing fatigue and weakness.

The symptoms of these forms of anemia are often subtle and gradual. Individuals may notice pallor, shortness of breath with exertion, dizziness, or a racing heartbeat, but sometimes fatigue is the only early warning sign. Folate deficiency is more likely in people with poor diets, certain digestive disorders, or increased needs (such as during pregnancy), while B12 deficiency is common in older adults, vegans, and those with absorption issues.

According to the Mayo Clinic and the Johns Hopkins Medicine, proper diagnosis involves checking specific vitamin levels—not just hemoglobin. Addressing these deficiencies with supplementation or dietary changes can quickly restore energy and well-being for many affected individuals.

29. Obesity-Related Fatigue

Carrying excess weight can have a profound impact on energy levels, but the connection between obesity and chronic fatigue is often missed in primary care. Extra body weight not only puts a strain on the heart and musculoskeletal system, but also increases the risk of sleep disorders such as obstructive sleep apnea. Even mild obesity may impair sleep quality by promoting airway obstruction, leading to unrefreshing sleep and daytime tiredness.

Obesity also contributes to chronic inflammation and hormonal imbalances, both of which can sap energy and exacerbate feelings of sluggishness. The heart and lungs work harder to supply oxygen to a larger body mass, making routine physical activities more tiring. Additionally, obesity is linked to insulin resistance and metabolic syndrome, further fueling fatigue through blood sugar fluctuations.

The CDC and Sleep Foundation stress that addressing weight through lifestyle changes, better sleep habits, and supportive care can dramatically improve energy and overall health. Recognizing obesity-related fatigue is key to breaking the cycle of tiredness and initiating effective interventions.

30. Polycystic Ovary Syndrome (PCOS)

Polycystic Ovary Syndrome (PCOS) is a common hormonal disorder that affects millions of women, often long before it is formally diagnosed. PCOS disrupts the delicate balance of reproductive hormones, leading to irregular periods, acne, excess hair growth, and weight gain. Yet, one of its most overlooked symptoms is persistent fatigue—sometimes years before other signs become noticeable.

Women with PCOS frequently struggle with insulin resistance, meaning their bodies don’t use blood sugar efficiently. This leads to energy crashes, cravings, and ongoing tiredness, even after adequate sleep. Chronic inflammation and imbalances in androgens (male hormones) also play a role in draining energy and affecting mood. Fatigue can easily be mistaken for stress, lifestyle factors, or “just part of being busy,” delaying appropriate evaluation and care.

According to the CDC and Johns Hopkins Medicine, early recognition of PCOS is crucial for managing symptoms, restoring energy, and reducing long-term health risks. Addressing PCOS through lifestyle changes, medications, and hormonal support can help women reclaim their vitality and overall well-being.

31. Vitamin D Deficiency

Vitamin D is best known for its role in bone health, but it also plays a vital part in energy production and immune function. Deficiency in this nutrient is surprisingly common, especially among those who spend little time outdoors, live in northern climates, or regularly use sunscreen. Without enough vitamin D, people may experience vague symptoms such as fatigue, muscle aches, and frequent infections—even before classic bone or mood issues appear.

Vitamin D helps regulate how cells use energy, influences neurotransmitter production, and supports the immune system’s ability to fight off illness. Low levels, therefore, can leave you feeling run-down, prone to colds, and unable to shake off a persistent sense of tiredness. Because these symptoms are nonspecific, many cases of deficiency go unnoticed or are attributed to other health problems.

According to the CDC and National Institutes of Health, simple blood tests can reveal low vitamin D levels, and supplementation or safe sun exposure can quickly restore well-being for many. If unexplained fatigue persists, checking vitamin D status is a valuable and often overlooked step.

32. Chronic Heart Arrhythmias

Chronic heart arrhythmias, such as atrial fibrillation or other irregular heart rhythms, can be a hidden source of ongoing fatigue. When the heart beats out of sync, it becomes less efficient at pumping blood throughout the body. This subtle reduction in blood flow means that vital organs—including the brain and muscles—may not receive the oxygen and nutrients they need to function at their best, resulting in persistent tiredness even during routine activities.

Not everyone with a heart arrhythmia experiences palpitations or chest discomfort. In many cases, fatigue, weakness, or lightheadedness are the primary symptoms, especially in older adults. Arrhythmias can be intermittent, making them easy to miss on a standard checkup or routine EKG. People with underlying heart disease, high blood pressure, or thyroid dysfunction are at increased risk.

The CDC and American Heart Association recommend that persistent fatigue without explanation should prompt a closer look at heart rhythm, often through extended monitoring. Early recognition and treatment of arrhythmias can restore energy, improve overall health, and prevent more serious complications.

33. Hidden Asthma or COPD

Not all cases of asthma or chronic obstructive pulmonary disease (COPD) present with obvious wheezing or severe shortness of breath. In fact, mild or subtle forms of these lung diseases can silently limit the amount of oxygen reaching the body’s tissues, resulting in persistent fatigue and low stamina. People may simply notice that they tire more easily, have trouble keeping up with others, or feel winded during daily activities.

This quiet reduction in lung function is often overlooked, especially in non-smokers, younger adults, or those with only occasional symptoms. Nighttime cough, frequent throat clearing, or a sense of chest tightness after exertion may be the only clues. Over time, even mild oxygen deprivation can sap energy and impair concentration, with symptoms easily mistaken for being out of shape or just aging.

The CDC and the American Lung Association stress the importance of spirometry and lung function testing for anyone with unexplained fatigue or exercise intolerance. Early identification and treatment can help restore energy, prevent complications, and dramatically improve quality of life.

34. Post-Concussion Syndrome

Post-concussion syndrome is a complex condition that can cause prolonged fatigue after a head injury, even when initial memory loss, headaches, and confusion have improved. The brain’s recovery from trauma is often slower than expected, and lingering tiredness is a common complaint among those affected. This fatigue may be profound—making it difficult to return to work, school, or regular physical activity.

Many people mistakenly believe that once the obvious symptoms of a concussion fade, they are fully healed. However, the brain may still be struggling with subtle changes in blood flow, neurotransmitter balance, and energy metabolism. Fatigue can persist for weeks or months, often accompanied by irritability, sensitivity to light or noise, and difficulty focusing. Because these symptoms are not always visible, post-concussion fatigue is sometimes dismissed or underestimated by others.

The CDC and the BrainLine emphasize the need for rest, gradual return to activity, and ongoing support for those recovering from concussions. Recognizing post-concussion syndrome as a cause of persistent tiredness is crucial for appropriate care and a full recovery.

35. Chronic Alcohol Use

Regular alcohol consumption is a frequently overlooked cause of chronic fatigue. While a drink or two may seem relaxing, chronic alcohol use disrupts natural sleep cycles, particularly the restorative rapid eye movement (REM) stage, leaving individuals feeling unrefreshed even after a full night’s rest. Over time, alcohol can also impair liver function and hinder the metabolism of nutrients critical for energy production.

People who drink regularly may notice increased tiredness, irritability, or difficulty focusing—symptoms often dismissed as stress or aging. Alcohol also acts as a diuretic, promoting dehydration, which further saps energy and compounds feelings of sluggishness. The cumulative effect of disrupted sleep, dehydration, and metabolic strain can persist even in those who don’t meet criteria for alcohol use disorder.

The CDC and Sleep Foundation highlight the strong link between alcohol and fatigue, recommending moderation or abstinence for those struggling with ongoing tiredness. Addressing alcohol use can dramatically improve sleep quality, daytime energy, and long-term health.

36. Chronic Viral Hepatitis

Chronic viral hepatitis, particularly hepatitis B and C, is a stealthy cause of persistent fatigue that may go unrecognized for years. These infections can linger in the body, slowly damaging liver cells and impairing metabolic functions essential for energy production. Many individuals with chronic hepatitis experience gradual, unexplained tiredness long before more obvious signs of liver disease—such as jaundice or abdominal swelling—appear.

Because hepatitis B and C often progress silently, fatigue may be the only symptom, leading to misattribution to stress, age, or lifestyle. Over time, the liver’s diminished ability to filter toxins and regulate nutrients can erode energy, affect concentration, and undermine immune function. In some cases, chronic hepatitis results from past exposures or medical procedures, making the connection to current symptoms even less apparent.

The CDC and the Hepatitis B Foundation stress the importance of screening, especially for those with risk factors or unexplained fatigue. Early detection and modern antiviral treatments can halt disease progression, improve well-being, and restore lost energy for many affected individuals.

37. Malnutrition and Poor Diet

Malnutrition isn’t limited to those who are underweight—people with overweight or obesity can also suffer from hidden nutrient deficiencies that sap their energy. Diets high in processed foods, sugar, and unhealthy fats but low in essential vitamins, minerals, and protein can impair the body’s ability to generate and sustain energy. Even if calorie intake is adequate or excessive, missing key nutrients like magnesium, B vitamins, or omega-3 fatty acids can cause fatigue, irritability, and brain fog.

Busy lifestyles and reliance on convenience foods mean many adults and children don’t get the variety of nutrients their bodies need for optimal function. Over time, this “hidden hunger” can affect everything from immune resilience to mental clarity and muscle strength. Symptoms of malnutrition may be subtle: brittle hair and nails, frequent illnesses, poor wound healing, or just persistent tiredness that doesn’t improve with rest.

The CDC and the Harvard T.H. Chan School of Public Health highlight the importance of a balanced, nutrient-rich diet for maintaining energy and well-being. Addressing nutritional gaps—regardless of body size—can be transformative for those struggling with chronic fatigue.

38. Multiple Sclerosis (Early Stages)

Multiple sclerosis (MS) is a chronic, autoimmune disease that affects the central nervous system, often presenting with unexplained fatigue long before more recognizable neurological symptoms appear. In its early stages, MS can cause overwhelming tiredness that doesn’t improve with rest, preceding episodes of vision changes, numbness, tingling, or weakness by months or even years. This fatigue can be so profound that it interferes with daily activities, work, and relationships.

The cause of MS fatigue is complex, involving immune system attacks on the protective covering of nerves, subtle inflammation, and changes in brain signaling. Because early MS fatigue is nonspecific and overlaps with many other conditions, it is frequently misattributed to stress, depression, or lifestyle factors. Standard blood tests and physical exams may be entirely normal in the beginning, delaying diagnosis.

The National MS Society and the CDC emphasize the need for a high index of suspicion and comprehensive neurological evaluation when persistent, unexplained fatigue is present. Early diagnosis and management can help slow disease progression and improve quality of life.

39. Chronic Sinusitis

Chronic sinusitis is a long-lasting inflammation of the sinuses that can easily masquerade as simple seasonal allergies. When the tissues lining the sinuses remain swollen for weeks or months, normal drainage is blocked, leading to congestion, facial pressure, and persistent tiredness. In addition to the physical discomfort, ongoing sinus inflammation disrupts sleep by causing nighttime congestion, postnasal drip, and frequent awakenings.

Many people with chronic sinusitis don’t realize their fatigue is connected to their sinuses. Symptoms such as headaches, reduced sense of smell, and mild fever may be so subtle or intermittent that the true culprit goes unrecognized. Instead, patients and even healthcare providers may attribute ongoing tiredness to allergies, stress, or lack of sleep.

According to the CDC and the American Academy of Otolaryngology-Head and Neck Surgery, effective management of chronic sinusitis—through saline rinses, nasal steroids, or in some cases, surgery—can greatly improve sleep quality and restore energy. Recognizing this condition is key for those whose fatigue persists despite addressing other common causes.

40. Hyperparathyroidism

Hyperparathyroidism is a disorder in which one or more of the parathyroid glands—tiny glands located near the thyroid—become overactive, leading to an imbalance in calcium regulation. This excess production of parathyroid hormone (PTH) causes blood calcium levels to rise, which can sap energy, cause muscle weakness, and create ongoing fatigue. The symptoms are often vague and develop gradually, making diagnosis especially challenging.

People with hyperparathyroidism may also experience bone pain, kidney stones, abdominal discomfort, and mild depression or confusion. However, fatigue and weakness are often the earliest and most persistent complaints. Because these symptoms overlap with so many other conditions, doctors may not immediately suspect a parathyroid issue—especially in older adults.

The Endocrine Society and the Mayo Clinic emphasize the importance of checking calcium and PTH levels in patients with unexplained fatigue and muscle symptoms. Treating hyperparathyroidism, often through surgery, can restore normal calcium balance and dramatically improve energy and quality of life.

41. Chronic Use of Caffeine

Caffeine is widely used for its ability to provide a quick energy boost and sharpen mental focus, but chronic overuse can actually backfire, leading to worsening tiredness over time. As people build tolerance, they often need larger amounts of caffeine to feel the same effects, and withdrawal between doses can cause headaches, irritability, and an energy slump. This cycle of stimulation and crash can disrupt natural sleep patterns and undermine overall energy levels.

Heavy caffeine intake—whether from coffee, tea, energy drinks, or soda—may initially mask the symptoms of fatigue, but it also interferes with restful sleep by increasing nighttime awakenings and reducing deep sleep stages. The result is chronic sleep deprivation, which accumulates over days and weeks, leaving individuals feeling perpetually drained despite consuming more caffeine.

According to the Sleep Foundation and the CDC, scaling back caffeine and improving sleep hygiene are key steps for those trapped in this cycle. Moderation and mindful timing of caffeine intake can help restore natural energy levels and reduce ongoing tiredness.

42. Hidden UTI (Urinary Tract Infection)

Urinary tract infections (UTIs) are best known for causing pain or burning with urination, but in older adults, they often present with far subtler symptoms. Silent or atypical UTIs may show up primarily as persistent fatigue, confusion, or even falls, rather than the classic urinary complaints. This makes them a frequently missed cause of chronic tiredness, particularly in seniors and those with underlying medical conditions.

The body’s immune response to infection can produce generalized inflammation, leading to tiredness, malaise, and mental fog. In the elderly, changes in the immune system and nervous system mean that UTIs may not trigger a fever or local pain, making diagnosis more difficult. Sometimes, a sudden decline in alertness or unexplained lethargy is the first and only clue.

The CDC and the Urology Care Foundation recommend considering UTIs in any older adult presenting with new or worsening fatigue or confusion. Simple urine tests and prompt treatment can reverse symptoms and restore energy when this hidden cause is identified.

43. Hypopituitarism

Hypopituitarism is a rare but serious condition in which the pituitary gland fails to produce enough of one or more essential hormones. Because the pituitary serves as the body’s “master gland,” its dysfunction can quietly undermine almost every aspect of metabolism and energy regulation. Reduced hormone output may result in profound fatigue, weakness, and decreased motivation—symptoms often mistaken for depression, aging, or stress.

Real-life cases highlight how insidious hypopituitarism can be. For example, a middle-aged individual may develop unexplained tiredness, weight gain, and sensitivity to cold over several years, only to discover low thyroid and adrenal hormones upon thorough evaluation. Women may experience irregular periods, while men might notice reduced libido or muscle mass. Because these changes tend to develop gradually, diagnosis is frequently delayed until symptoms become severe or life-threatening.

According to the Endocrine Society and Mayo Clinic, comprehensive hormone testing is crucial for anyone with unexplained, persistent fatigue and multiple subtle symptoms. Proper treatment can restore hormone balance and dramatically improve energy and quality of life.

44. Chronic Exposure to Toxins (e.g., Mold, Heavy Metals)

Chronic exposure to environmental toxins—such as mold, lead, mercury, or other heavy metals—can be an elusive cause of persistent fatigue. These substances can enter the body through inhalation, ingestion, or skin contact, gradually affecting the nervous system, immune function, and energy metabolism. Symptoms of toxic exposure are often vague, including tiredness, headaches, muscle aches, memory problems, and mood changes.

Mold exposure, for example, is common in damp or water-damaged buildings and may cause a cluster of symptoms collectively known as “sick building syndrome.” Heavy metals can accumulate from contaminated water, food, or occupational hazards. People may not connect their ongoing tiredness to environmental factors, especially when symptoms develop slowly and are easily attributed to stress or aging.

The CDC and the Agency for Toxic Substances and Disease Registry (ATSDR) recommend considering environmental exposures in anyone with unexplained, ongoing fatigue—especially if others in the same environment have similar complaints. Identification and removal of the source, along with appropriate treatment, can restore energy and prevent further harm.

45. Undiagnosed Sleep Disorders (Other Than Apnea)

While sleep apnea is well-known, many other sleep disorders can silently drain energy and go undiagnosed for years. Conditions such as narcolepsy, restless sleep disorder, insomnia, and circadian rhythm disturbances (like delayed sleep phase syndrome) can all disrupt the quality and timing of sleep, resulting in chronic fatigue that’s not relieved by rest.

Narcolepsy is characterized by overwhelming daytime sleepiness and sudden sleep “attacks,” sometimes accompanied by muscle weakness or vivid dreams. Circadian rhythm disorders cause people’s internal clocks to fall out of sync with societal norms, making it hard to maintain consistent sleep and wake times. Even less recognized issues, such as periodic limb movement disorder, can fragment sleep and leave individuals persistently tired.

These less common sleep problems may be mistaken for laziness, depression, or lack of willpower, especially in teens and young adults. According to the Sleep Foundation and the CDC, specialized sleep studies and a detailed sleep history are essential for diagnosis. Identifying and treating these conditions can dramatically improve energy, alertness, and quality of life.

46. Chronic Inflammatory Conditions (e.g., IBD)

Chronic inflammatory conditions of the gut, such as Crohn’s disease and ulcerative colitis—collectively called inflammatory bowel disease (IBD)—can cause fatigue that persists even when digestive symptoms are well controlled or in remission. Ongoing low-grade inflammation affects the body’s ability to absorb nutrients and triggers an immune response that saps energy reserves, often leading to persistent tiredness and reduced stamina.

Even when bowel movements are normal and pain is absent, people with IBD frequently report “never feeling rested” or struggling with brain fog and weakness. This can be due to subtle anemia, vitamin and mineral deficiencies, or the chronic effects of inflammation itself. The fatigue may be dismissed as a side effect of medication, lifestyle, or stress, making it easy to overlook the connection to underlying gut inflammation.

According to the Crohn’s & Colitis Foundation and CDC, managing inflammation, optimizing nutrition, and addressing sleep quality are vital for reducing fatigue in IBD. Ongoing tiredness should prompt a comprehensive assessment—even during periods of remission—to ensure all contributing factors are addressed.

47. Postural Orthostatic Tachycardia Syndrome (POTS)

Postural Orthostatic Tachycardia Syndrome (POTS) is an autonomic nervous system disorder that is frequently overlooked, especially in adolescents and young adults. POTS is characterized by a rapid increase in heart rate—often by 30 beats per minute or more—when moving from lying down to standing. This abnormal response causes blood to pool in the lower body, leading to lightheadedness, palpitations, and severe fatigue with upright posture.

Symptoms can include dizziness, brain fog, headaches, and even fainting, but unrelenting tiredness is often the most debilitating feature. Many young people with POTS are misdiagnosed with anxiety, depression, or simply told they are “out of shape.” The fatigue is not relieved by rest and can make everyday activities, such as attending school or work, feel overwhelming.

According to the Dysautonomia International and the Cleveland Clinic, diagnosis of POTS requires careful monitoring of heart rate and blood pressure with positional changes. Recognizing and treating POTS can dramatically improve quality of life for those suffering from unexplained fatigue and lightheadedness.

48. Chronic Jet Lag or Shift Work

Chronic disruption of the body’s natural circadian rhythms, as experienced by frequent travelers or shift workers, is a well-established but often underestimated cause of persistent fatigue. Jet lag and rotating shifts force the body to operate out of sync with its internal clock, leading to trouble falling asleep, staying asleep, and feeling rested. Over time, this constant misalignment can erode both physical and mental energy, regardless of total hours spent in bed.

Real-life examples abound: flight attendants, nurses, factory workers, doctors, and truck drivers all face unique challenges in maintaining regular sleep-wake patterns. The result can be ongoing tiredness, irritability, digestive problems, and impaired concentration. This “social jet lag” is not easily remedied by days off, as the body struggles to reset its rhythms after repeated disruptions.

The Sleep Foundation and the CDC highlight the importance of strategic light exposure, consistent routines when possible, and prioritizing sleep hygiene for those affected. Addressing circadian rhythm disruption can help combat chronic fatigue and improve overall well-being for those with demanding schedules.

49. Underlying Neurological Disorders

Early neurological disorders, such as Parkinson’s disease or the initial stages of dementia, can present with unexplained fatigue long before classic symptoms like tremors or memory loss become obvious. The brain’s intricate control over movement, motivation, and alertness means even subtle changes in neurological function can sap energy, dull mental sharpness, and affect mood.

For example, in Parkinson’s disease, fatigue and a general sense of slowed movement or thinking may appear years before the hallmark motor symptoms. Similarly, early dementia or Alzheimer’s disease often manifests as loss of initiative, increased need for naps, or difficulty maintaining attention. These changes are easily mistaken for depression, aging, or “burnout,” delaying appropriate diagnosis and care.

According to the Parkinson’s Foundation and the Alzheimer’s Association, persistent tiredness or loss of drive in older adults warrants careful neurological evaluation. Early recognition of these conditions is crucial, as appropriate interventions can improve quality of life and help manage symptoms as the disease progresses.

50. Undiagnosed Blood Disorders (e.g., Sickle Cell, Thalassemia)

Inherited blood disorders such as sickle cell disease and thalassemia are often thought of as childhood illnesses, but many adults live with undiagnosed or mild forms that manifest primarily as chronic fatigue. These conditions impair the blood’s ability to carry oxygen efficiently, resulting in persistent tiredness, weakness, and sometimes unexplained pain or shortness of breath. Because symptoms can be subtle or intermittent, they may go unrecognized for years.

Adults with undiagnosed sickle cell trait or thalassemia minor may notice decreased stamina or frequent need for rest, but not attribute these issues to a blood disorder. Mild anemia, pale skin, or jaundice may also be present, but are often mistakenly blamed on poor diet, stress, or other lifestyle factors. Routine blood tests may not always detect these inherited conditions unless specific screening is performed.

According to the CDC and the Thalassemia International Federation, awareness and targeted testing are essential for anyone with unexplained fatigue and a family history of blood disorders. Early diagnosis can lead to better management strategies and improved quality of life.

Conclusion

Persistent, unexplained fatigue is never “just in your head.” As this comprehensive guide reveals, there are dozens of hidden causes that doctors may overlook—from subtle hormonal shifts and nutritional gaps to undiagnosed infections and chronic health conditions. Recognizing these possibilities is critical for restoring energy and quality of life. If you or someone you know is struggling with ongoing tiredness, don’t settle for vague explanations.

Discuss your symptoms openly with your healthcare provider, and consider requesting targeted screening for the conditions described here. For more information or support, resources like the CDC and Mayo Clinic offer valuable tools. With thorough evaluation and advocacy, it’s possible to uncover the true cause—and take meaningful steps toward lasting relief.

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