Strange Body Changes That Warn of Heart Problems

1. Swelling in the Ankles and Feet

One of the earliest and most easily overlooked signs of underlying heart problems is swelling, or edema, in the ankles and feet. This swelling occurs when a weakened heart cannot efficiently pump blood, causing fluid to accumulate in the lower extremities due to gravity. This phenomenon is commonly seen in congestive heart failure, where the heart’s reduced pumping ability leads to fluid buildup in tissues.

In mild cases, the swelling may be barely noticeable, but as heart function deteriorates, the swelling can become pronounced and persistent, especially after long periods of standing or sitting. It is important to monitor for symmetrical swelling in both ankles and feet, as this pattern is more suggestive of heart-related issues than swelling caused by injury or infection.

If you notice swelling that does not resolve with elevation or rest, or if it is accompanied by other symptoms such as shortness of breath or unexplained weight gain, seek medical attention promptly. Early recognition and intervention can improve outcomes for those with heart conditions. For more information, visit the CDC’s heart failure resources.

2. Blue-Tinted Lips or Fingertips

A sudden or persistent bluish tint to the lips or fingertips, known medically as cyanosis, can signal that the body is not receiving enough oxygenated blood due to decreased heart output. When the heart’s ability to pump blood is compromised, oxygen delivery to peripheral tissues—such as the skin, lips, and extremities—may be insufficient, resulting in this noticeable color change. Cyanosis is often more visible in cool or poorly lit environments and can be easily overlooked if mild.

For example, a person with advanced heart failure may notice their lips or fingertips turning blue after climbing stairs or during episodes of breathlessness. This symptom can also accompany congenital heart defects in children or sudden cardiovascular events in adults.

If blue discoloration appears suddenly, especially alongside chest pain, difficulty breathing, or confusion, it constitutes a medical emergency and requires immediate care. Prompt treatment can be life-saving, as cyanosis indicates severely reduced oxygen in the blood. For more on cyanosis and heart health, consult the Mount Sinai Health Library or the CDC’s heart disease symptoms guide.

3. Sudden, Unexplained Fatigue

A sudden onset of unexplained fatigue can be an early indicator of heart problems, often resulting from the heart’s decreased ability to supply vital organs and tissues with adequate oxygen-rich blood. When the heart’s pumping efficiency is compromised, less oxygen reaches the muscles and brain, leading to persistent tiredness that doesn’t improve with rest. This type of fatigue is distinct from the tiredness most people experience after a poor night’s sleep or a busy day—it can be overwhelming, constant, and interfere with daily activities such as climbing stairs or carrying groceries.

Unlike normal tiredness, heart-related fatigue may be accompanied by other symptoms like shortness of breath, dizziness, or chest discomfort. For example, people experiencing heart failure often report feeling exhausted even after light activity, sometimes struggling to complete basic household tasks.

If you notice a marked decrease in your energy levels without a clear cause, especially if it is accompanied by other unusual symptoms, it is important to consult a healthcare provider. Early intervention can make a significant difference in outcomes. For additional information, visit the American Heart Association’s warning signs of heart failure or the CDC’s heart disease symptoms overview.

4. Persistent Cough or Wheezing

A chronic cough or persistent wheezing that does not resolve with typical treatments may be linked to underlying heart problems, particularly when fluid begins to accumulate in the lungs due to poor heart function. This condition, often referred to as pulmonary congestion, is commonly associated with heart failure. As the heart struggles to pump blood efficiently, fluid backs up into the lungs, irritating the airways and triggering a cough that can be dry or produce frothy, sometimes pink-tinged sputum.

For instance, someone with congestive heart failure might notice worsening cough or wheezing when lying down at night, sometimes requiring extra pillows to sleep comfortably. Unlike respiratory infections, which often bring fever, sore throat, or sudden onset, heart-related coughs tend to persist over weeks or months and are not associated with typical cold symptoms.

If you experience a lingering cough or wheezing that does not improve with over-the-counter remedies or is accompanied by swelling, shortness of breath, or fatigue, it’s important to seek medical advice. Recognizing this sign early can prevent complications. For more details, visit the American Heart Association’s guide to heart failure symptoms or read about heart failure signs at the NHLBI.

5. Unusual Heartbeat Sensations

Experiencing unusual sensations in your heartbeat—such as fluttering, pounding, or a feeling that your heart is skipping beats—may signal the presence of arrhythmias or irregular heart rhythms. While occasional palpitations are common and often harmless, especially during stress or after consuming caffeine, persistent or pronounced changes can be a warning sign of more serious heart conditions. Arrhythmias occur when the electrical impulses that coordinate your heartbeats are disrupted, leading to rhythms that are too fast, too slow, or erratic.

A normal heart rate typically ranges from 60 to 100 beats per minute at rest, with slight variations during exercise, excitement, or deep relaxation. However, abnormal patterns—such as frequent skipped beats, sustained racing, or fluttering sensations—should not be ignored, especially if they occur at rest or are accompanied by symptoms like dizziness, chest pain, or fainting.

If you notice that your heartbeat feels irregular for more than a few seconds, or if episodes are recurrent and unexplained, it’s important to consult a healthcare provider. Some arrhythmias can increase the risk of stroke or cardiac arrest if left untreated. For further reading, visit the CDC’s arrhythmia resources or the American Heart Association’s arrhythmia guide.

6. Shortness of Breath with Mild Activity

Experiencing shortness of breath, even with mild activity, can be a critical indicator of heart problems. When the heart cannot pump blood efficiently, oxygen delivery to the muscles and organs is compromised, leaving you feeling breathless during tasks that used to be effortless. This symptom, known as dyspnea, may first appear during routine activities such as walking up a short flight of stairs, carrying groceries, or even light housework.

For example, someone might notice they are unable to walk their usual route without stopping to catch their breath, or that making the bed or taking a shower has suddenly become exhausting. Unlike shortness of breath from a cold or intense physical exertion, heart-related breathlessness tends to persist and may worsen over time, even with minimal exertion.

It is important to track how often and under what circumstances you experience breathlessness. Keeping a diary of symptoms can help your healthcare provider identify patterns and determine the underlying cause. Seek medical advice if you notice a new or unexplained shortness of breath, especially if it occurs at rest or is accompanied by chest pain or swelling. For more information, visit the American Heart Association’s warning signs of heart failure or the CDC’s guide to heart disease symptoms.

7. Dizziness or Lightheadedness

A sudden feeling of dizziness or lightheadedness can be a warning sign that the brain is not getting enough blood and oxygen, often due to underlying heart problems. When the heart’s pumping ability is compromised, blood flow to the brain may be temporarily reduced, causing sensations of unsteadiness, faintness, or near-fainting. This symptom can occur suddenly or gradually and may be triggered by standing up quickly, physical exertion, or even just being at rest.

For instance, someone might feel a wave of dizziness when rising from a chair or after walking a short distance, forcing them to stop and regain their balance. While occasional lightheadedness can sometimes be attributed to dehydration or standing up too fast, heart-related causes tend to be more persistent, especially if associated with other symptoms like palpitations, chest pain, or shortness of breath.

It’s important to pay attention to new or frequent episodes of dizziness, particularly if they are unexplained or interfere with daily functioning. Seek medical evaluation if dizziness is recurrent, severe, or accompanied by fainting, as this may indicate a serious cardiovascular issue. For further reading, visit the American Heart Association’s resource on arrhythmia symptoms or the CDC’s overview of heart disease symptoms.

8. Cold or Numb Extremities

Coldness or numbness in your hands and feet can be a direct result of poor circulation, often caused by a weakened or failing heart. When the heart cannot pump blood effectively, your body prioritizes vital organs like the brain and heart itself, reducing blood flow to the extremities. As a result, you may notice your fingers and toes feeling unusually cold to the touch or experience intermittent numbness and tingling.

For example, a person with chronic heart failure might find it difficult to warm their hands even in heated environments, or notice that their toes turn pale or bluish after sitting for long periods. Unlike temporary coldness from environmental exposure, heart-related symptoms tend to persist and may worsen over time.

It’s important to monitor for additional signs such as persistent swelling, changes in skin color, slow-healing sores, or pain in the extremities, as these may indicate more advanced circulatory problems. If you observe ongoing coldness, numbness, or color changes in your hands or feet, consult a healthcare professional for evaluation. Learn more about circulation problems and heart health from the American Heart Association and the CDC’s heart disease resources.

9. Chest Discomfort (Not Always Pain)

Chest discomfort is often associated with heart problems, but it doesn’t always present as sharp pain. Instead, many people experience vague sensations such as pressure, tightness, fullness, burning, or a dull ache in the chest. These atypical symptoms can be misleading, causing individuals to dismiss them as indigestion, muscle strain, or anxiety. Such sensations may come and go, last for several minutes, or be triggered by physical activity or emotional stress.

For example, consider a case where a middle-aged woman felt a persistent pressure and mild burning in her chest after walking up a hill. She initially attributed it to heartburn, but when the sensation returned at rest and was accompanied by mild shortness of breath, she sought medical help. Testing revealed underlying coronary artery disease, highlighting how non-classic chest symptoms can signal serious heart issues.

To differentiate from indigestion, pay attention to whether the discomfort worsens with exertion and improves with rest, or if it’s accompanied by symptoms like shortness of breath, nausea, or sweating. If you’re unsure, it’s always best to err on the side of caution and seek prompt evaluation. For more, read the American Heart Association’s warning signs of heart attack and the CDC’s guide to heart disease symptoms.

10. Jaw, Neck, or Back Pain

Heart problems are not always signaled by chest pain; sometimes, they present as discomfort in seemingly unrelated areas such as the jaw, neck, or back. This phenomenon, known as referred pain, occurs because the nerves supplying the heart and these regions share common pathways. As a result, pain from the heart can be felt in places distant from the chest, leading people to overlook a cardiac cause.

For example, an individual experiencing a heart attack may feel a persistent ache or pressure in the lower jaw, upper back, or neck rather than in the chest. In one real-world case, a man attributed his upper back tightness to poor posture, but when it persisted and was accompanied by mild shortness of breath, he sought evaluation and was found to have significant coronary artery disease.

Pain in the jaw, neck, or back is particularly concerning if it appears suddenly, is severe, or is accompanied by other symptoms such as shortness of breath, sweating, dizziness, or nausea. These signs warrant immediate medical attention. For more information on atypical heart attack presentations, visit the American Heart Association’s warning signs page or the CDC’s symptom guide.

11. Sudden Weight Gain

A rapid increase in body weight over a short period—often several pounds within a few days—can be a significant warning sign of heart failure. Unlike normal daily fluctuations due to changes in diet or hydration, sudden weight gain in the context of heart problems is usually caused by fluid retention. When the heart cannot pump blood effectively, fluid may build up in tissues, particularly in the legs, abdomen, and lungs, leading to noticeable swelling and an increase in weight.

For instance, a person with undiagnosed heart failure might find that their shoes feel tighter or that their rings no longer fit, even though their eating habits haven’t changed. Rapid weight gain of more than 2-3 pounds in a single day or 5 pounds in a week should prompt concern, especially if accompanied by swelling, shortness of breath, or fatigue.

Monitoring your weight daily and keeping a record can help detect these changes early, allowing for timely medical intervention. If you notice unexplained or persistent weight gain, consult your healthcare provider promptly. For further information, review the American Heart Association’s warning signs of heart failure and the CDC’s resources on heart failure.

12. Nighttime Urination (Nocturia)

Frequent nighttime urination, known as nocturia, can be an early sign of heart failure. When the heart’s pumping ability declines, blood flow to the kidneys is reduced during the day, leading to fluid retention in the legs and tissues. At night, when you lie down, this excess fluid returns to the bloodstream, increasing kidney filtration and resulting in the need to urinate more often.

For example, someone with undiagnosed heart failure may find themselves waking up several times each night to urinate, despite not increasing their fluid intake before bed. This can be frustrating and disruptive to sleep, leading to daytime fatigue and decreased quality of life. Nocturia related to heart problems is usually persistent and may be accompanied by other symptoms such as swelling in the legs, shortness of breath, or unexplained weight gain.

While occasional nighttime urination can be normal—especially with age, certain medications, or increased fluid consumption—persistent or worsening nocturia should be discussed with a healthcare professional. Early detection of underlying heart issues can help prevent complications. For more information, visit the American Heart Association’s guide to heart failure symptoms and the National Institute of Diabetes and Digestive and Kidney Diseases’ resource on nocturia.

13. Loss of Appetite or Nausea

A reduced appetite or frequent nausea can be surprising symptoms of heart problems, particularly in cases of heart failure. When the heart is unable to pump blood effectively, less blood reaches the digestive organs, which can slow digestion and cause discomfort. This impaired blood flow may lead to a feeling of fullness after only a few bites, a distaste for food, or even bouts of nausea and vomiting.

For example, a person with undiagnosed heart failure might notice they are skipping meals or feeling queasy, even when they haven’t eaten much. These symptoms can worsen as fluid accumulates in the abdomen, putting pressure on the stomach and intestines. It’s common for these digestive complaints to be misattributed to a stomach virus, stress, or dietary issues, delaying proper diagnosis.

If you experience persistent loss of appetite, unexplained nausea, or early satiety—especially when combined with other signs of heart trouble such as swelling, fatigue, or shortness of breath—it’s important to consult a healthcare provider. Early intervention can help prevent complications. For further reading, visit the American Heart Association’s list of heart failure symptoms and the CDC’s resource on heart failure.

14. Persistent Hiccups

While hiccups are usually harmless and short-lived, persistent or recurring hiccups can occasionally be linked to heart problems. This rare symptom may occur when irritation or inflammation near the heart—such as from a heart attack or pericarditis—affects the phrenic or vagus nerves, which play a role in controlling the diaphragm. As a result, the diaphragm spasms involuntarily, leading to ongoing hiccup episodes that last for hours or even days.

One notable case involved a man who experienced unrelenting hiccups for days, only to later discover he was having a heart attack. Because persistent hiccups often seem trivial or unrelated to heart health, they are frequently overlooked by both patients and healthcare providers. This can delay critical diagnosis and treatment, especially if other subtle symptoms—like mild chest discomfort, fatigue, or shortness of breath—are also dismissed.

If you or someone you know experiences hiccups that continue for more than 48 hours, especially when accompanied by other warning signs of heart issues, seeking medical attention is important. To learn more about unusual heart symptoms, visit the Healthline’s guide to unusual heart attack symptoms and the American Heart Association’s warning signs.

15. Skin Rashes or Spots

Unusual skin changes such as rashes, red or purple spots (petechiae), or unexplained bruising can sometimes be linked to underlying heart problems. Conditions like infective endocarditis—a bacterial infection of the heart lining or valves—can cause immune or vascular reactions that manifest on the skin as small, pinpoint dots or larger, bruise-like patches. Vascular issues, such as poor circulation or vasculitis, may also lead to skin discoloration, mottling, or non-healing sores.

For example, someone with endocarditis might notice tiny red spots on their hands, feet, or inside the mouth, which differ from a typical allergic rash in that they don’t itch and do not go away with common treatments. Unlike allergic or contact rashes, these skin changes are persistent and can be accompanied by fever, fatigue, or unexplained aches.

If you observe unusual, lasting skin rashes or spots—especially when associated with other symptoms such as fever, night sweats, or heart murmur—seek medical evaluation. Early recognition of these signs can be crucial for prompt treatment. For more, visit the CDC’s resource on endocarditis and the Cleveland Clinic’s guide to endocarditis.

16. Fainting Spells (Syncope)

Fainting, medically known as syncope, can occur when the heart is unable to maintain adequate blood flow to the brain. Heart-related causes of fainting include arrhythmias (irregular heartbeats), structural heart abnormalities, or obstruction of blood flow. When the brain receives insufficient oxygen for even a few seconds, a person may suddenly lose consciousness, often without warning. This type of fainting is especially concerning because it can signal serious underlying cardiac conditions that may increase the risk of sudden cardiac arrest.

A real-world example might involve someone fainting while climbing stairs or standing up quickly, regaining consciousness within seconds but feeling weak or confused afterward. If fainting occurs during physical activity or is accompanied by chest pain, palpitations, or shortness of breath, the likelihood of a heart cause is higher and the situation is more urgent.

Recurrent or unexplained fainting spells should never be ignored, as they may be the only warning sign of a life-threatening heart problem. Immediate medical evaluation is necessary to determine the cause and reduce the risk of complications. For more on heart-related syncope, visit the American Heart Association’s arrhythmia resource and the CDC’s guide to heart disease symptoms.

17. Swollen Abdomen

A swollen or distended abdomen, known medically as ascites, can be an important but sometimes overlooked sign of advanced heart failure. When the heart’s pumping function is impaired, blood can back up in the veins that lead to the liver and intestines, causing fluid to leak into the abdominal cavity. This buildup results in noticeable abdominal swelling, increased waist size, and sometimes discomfort or a feeling of heaviness.

Unlike temporary bloating from overeating or digestive issues, ascites caused by heart failure tends to develop gradually and is persistent. For example, someone may notice their clothes no longer fit around the waist or they feel full quickly, even after small meals. As the condition progresses, the swelling can become pronounced and may be accompanied by swelling in the legs, shortness of breath, or rapid weight gain.

If you experience unexplained or persistent abdominal swelling—especially alongside other symptoms of heart dysfunction—it is crucial to seek medical evaluation. Prompt treatment can help manage symptoms and prevent complications. Learn more about ascites and heart failure from the American Heart Association’s guide to heart failure symptoms and the CDC’s heart failure resource.

18. Difficulty Sleeping Flat

Difficulty sleeping flat, a condition known as orthopnea, is a common symptom of heart failure. When the heart cannot pump efficiently, fluid can accumulate in the lungs, making it challenging to breathe comfortably while lying down. This causes many people to prop themselves up with extra pillows or sleep in a recliner to avoid waking up gasping for air. Orthopnea is often a sign that heart function is significantly impaired and that fluid is backing up from the heart into the lungs.

A typical example involves someone who previously slept soundly in bed but now finds it necessary to sleep with their upper body elevated or to wake up multiple times during the night feeling breathless. Unlike temporary breathing difficulties caused by a cold or allergies, heart-related orthopnea tends to be persistent and worsen over time if left untreated.

If you notice new or worsening difficulty breathing when lying flat, especially if it is accompanied by swelling, rapid weight gain, or persistent cough, it is important to consult a healthcare provider promptly. Early intervention can prevent further complications. Learn more at the American Heart Association’s heart failure warning signs and the CDC’s heart failure resource.

19. Unexplained Coughing at Night

Unexplained nighttime coughing is a classic but often overlooked sign of heart failure. As the heart’s pumping ability declines, fluid can back up into the lungs, particularly when lying down. This accumulation of fluid irritates the airways and can trigger a persistent, dry, or sometimes frothy cough that disrupts sleep. Unlike a cough caused by a cold, allergies, or asthma, this heart-related cough typically worsens at night or when reclining and may be accompanied by shortness of breath or wheezing.

For example, someone with undiagnosed heart failure might find themselves waking up several times each night to cough, even in the absence of a sore throat or any signs of infection. They may notice the need to sit upright or use several pillows to alleviate the cough and breathe more comfortably.

If you experience a persistent cough that is most noticeable at night and does not resolve with typical cold remedies, it is important to monitor for other symptoms such as swelling, breathlessness, or rapid weight gain. These patterns should prompt a discussion with your healthcare provider. Learn more from the American Heart Association’s list of heart failure symptoms and the CDC’s heart failure overview.

20. Dark or Purple Lines Under Fingernails

Dark or purple lines appearing beneath the fingernails, known as splinter hemorrhages, can be a subtle but important indicator of heart problems, particularly infective endocarditis. These small, linear streaks resemble splinters and are caused by tiny blood clots damaging the small capillaries under the nails. While trauma to the fingernail can also cause splinter hemorrhages, the presence of multiple unexplained lines—especially when accompanied by other symptoms—may warrant further investigation.

For example, a person with no recent nail injuries might notice thin, dark lines running in the direction of nail growth. If these are accompanied by fever, fatigue, or persistent aches, it could signal a heart infection such as endocarditis. Because splinter hemorrhages may be easily mistaken for minor injuries or dismissed as cosmetic issues, heart-related causes can be missed without careful attention.

If you discover unexplained dark or purple lines under your nails, particularly if you also have a history of heart murmur, dental procedures, or intravenous drug use, it’s important to discuss these findings with your doctor. For more information, visit the CDC’s resource on endocarditis and the Cleveland Clinic’s guide to endocarditis symptoms.

21. Puffy Eyes in the Morning

Waking up with puffy or swollen eyelids may seem like a minor annoyance, but it can sometimes be a sign of underlying heart problems, particularly heart failure. Fluid retention is a hallmark of heart dysfunction, and while it often affects the ankles, feet, or abdomen, it can also manifest as subtle swelling around the eyes, especially after lying down overnight. This swelling is typically most noticeable in the morning and may resolve as you go about your day.

For example, someone may notice that their eyelids feel heavy or look unusually swollen upon waking, even if they haven’t consumed excess salt or cried the night before. Puffy eyes caused by heart-related fluid retention tend to persist or recur regularly and may occur alongside other symptoms such as swelling in the legs, sudden weight gain, or shortness of breath.

While puffy eyes can also result from allergies, lack of sleep, or dietary factors, it is important to consider the broader context and look for additional warning signs. If morning eye puffiness is persistent or accompanied by other symptoms of fluid overload, consult a healthcare provider for evaluation. For more information, see the American Heart Association’s list of heart failure symptoms and the CDC’s heart failure resource.

22. Red or Swollen Gums

Red, swollen, or bleeding gums may not only indicate gum disease but could also signal or contribute to heart problems. The oral-systemic link highlights how inflammation in the gums, known as periodontal disease, can both reflect and worsen cardiovascular health. Bacteria from infected gums can enter the bloodstream, promoting inflammation and plaque buildup in arteries, which increases the risk of heart disease and stroke. Conversely, poor heart function can diminish the body’s ability to fight gum infections, creating a cycle of worsening health.

For instance, someone with untreated gum disease may notice more frequent bleeding during brushing and persistent gum swelling. Unlike mild irritation from brushing too hard, periodontal disease is characterized by redness, tenderness, and gums that pull away from the teeth. Research shows that individuals with gum disease are more likely to develop heart issues, and those with heart disease may experience more severe gum problems.

Maintaining good oral hygiene—brushing twice daily, flossing, and regular dental checkups—can help protect both your mouth and heart. If you have persistent gum issues, especially with other heart risk factors, consult both your dentist and healthcare provider. Learn more from the CDC’s periodontal disease page and the American Heart Association’s article on gum and heart disease.

23. Clubbed Fingertips

Clubbing of the fingertips is a physical change characterized by the enlargement and rounding of the tips of the fingers, with the nails curving around the fingertips. This condition develops gradually and is often a response to long-term low oxygen levels in the blood, a state known as chronic hypoxemia. While clubbing can be associated with various medical conditions, it is particularly linked to congenital heart defects, chronic heart failure, and certain lung diseases.

For example, someone with an undiagnosed congenital heart defect may notice that their fingertips become bulbous and the angle between the nail and the nail bed increases. Unlike temporary swelling from injury or infection, clubbing is persistent and typically affects both hands equally. In advanced stages, the nails may feel spongy or soft to the touch.

It is important to monitor for other signs of low oxygen, such as blue-tinged lips or unexplained fatigue. If you observe clubbing of the fingers or toes, especially if accompanied by breathing difficulties or a history of heart or lung issues, seek medical evaluation. For further information, visit the Cleveland Clinic’s guide to clubbing and the CDC’s heart disease resources.

24. Unexplained Bruising

Unexplained bruising can be a subtle sign of underlying heart disease, especially when changes in circulation and blood clotting are involved. Heart conditions can affect the way blood flows through the vessels, and some treatments—such as blood thinners prescribed after a heart attack or for atrial fibrillation—can increase the risk of bruising. Additionally, weakened blood vessels and impaired clotting due to poor heart function may result in bruises that appear without obvious injury.

For example, a patient with congestive heart failure who is taking anticoagulant medications might notice purple or blue marks on their arms or legs after minimal or no trauma. Unlike bruises from everyday bumps, these marks may be larger, appear more frequently, or take longer to heal. In some cases, they may even develop in unusual areas, like the abdomen or back.

Red flags include sudden, severe bruising, bruising accompanied by bleeding from the gums or nose, or the appearance of petechiae (small, pinpoint red spots). If you experience these symptoms, especially in the context of heart disease or its treatments, seek prompt medical evaluation. For more, read the American Heart Association’s information on bleeding and bruising and the CDC’s heart disease symptoms guide.

25. Frequent Headaches

Frequent headaches can sometimes be a sign of underlying heart or vascular problems, particularly high blood pressure (hypertension). When blood pressure rises to high levels, it can put excessive strain on blood vessels in the brain, leading to headaches that may feel dull, throbbing, or persistent. These headaches are often most noticeable in the morning or after periods of stress, and can be accompanied by other symptoms such as blurred vision, dizziness, or nosebleeds.

Unlike tension headaches or migraines, which may have identifiable triggers or patterns, headaches caused by hypertension often lack a clear cause and persist despite rest or over-the-counter remedies. For example, someone with undiagnosed high blood pressure might notice a pattern of morning headaches that gradually worsen or are accompanied by a sense of pressure around the temples or at the base of the skull.

If you experience frequent or severe headaches—especially if paired with other warning signs like vision changes or chest discomfort—it’s important to check your blood pressure regularly. Persistent hypertension can damage the heart and blood vessels over time. For more information, visit the CDC’s resource on high blood pressure and the American Heart Association’s guide to high blood pressure.

26. Confusion or Trouble Concentrating

Confusion, memory lapses, or difficulty focusing can sometimes be linked to heart problems, especially when the heart is unable to pump enough blood to meet the brain’s needs. Poor cardiac output means less oxygen and nutrients reach the brain, leading to symptoms of mental fog, forgetfulness, or even sudden confusion. These cognitive changes can be subtle at first, such as misplacing objects more frequently or struggling to follow conversations, but may become more pronounced as heart function worsens.

For instance, an older adult with chronic heart failure might notice increased difficulty remembering appointments, staying organized, or following familiar routines. These symptoms could be mistakenly attributed to normal aging or stress but may actually reflect reduced brain perfusion due to heart dysfunction. Acute confusion, or delirium, can also arise suddenly during a heart failure crisis or after a heart attack.

If you or a loved one experiences new or worsening confusion, trouble concentrating, or sudden mental changes—especially in the context of other heart symptoms—seek prompt medical assessment. These signs warrant a thorough evaluation to rule out heart-related causes. To learn more, visit the American Heart Association’s heart failure symptoms and the CDC’s heart failure resource.

27. Erectile Dysfunction

Erectile dysfunction (ED) is often thought of as a quality-of-life issue, but it can also serve as an early warning sign of heart disease. Achieving and maintaining an erection depends on healthy blood flow, so problems with the blood vessels—such as atherosclerosis, or hardening of the arteries—can impede circulation to the penis. Since the blood vessels in the penis are smaller and more sensitive than those supplying the heart, ED may appear years before symptoms of heart disease like chest pain or shortness of breath.

For example, a man in his 40s or 50s who suddenly develops persistent difficulties with erections, despite no obvious psychological stressors, may be experiencing the first signs of underlying vascular disease. Unlike temporary ED caused by situational anxiety or fatigue, vascular-related ED tends to be ongoing and progressively worsens over time.

Men experiencing persistent erectile difficulties should feel encouraged to discuss the issue openly with their healthcare provider, as it can prompt early cardiovascular assessment and intervention. Addressing ED not only improves quality of life but may also help prevent future heart events. For additional information, see the CDC’s resource on ED and heart disease and the American Heart Association’s article on ED as a heart warning sign.

28. Yellowish Plaques on Eyelids (Xanthelasma)

Yellowish, flat or slightly raised plaques around the eyelids—known as xanthelasma—are deposits of cholesterol that can serve as a visible warning sign of elevated cholesterol levels and an increased risk for heart disease. These painless growths typically appear on the inner corners of the upper or lower eyelids and may develop gradually over time. Xanthelasma is most common in middle-aged and older adults and can occur even in those without a known history of high cholesterol.

For example, a person may notice soft, yellowish patches forming near the eyes, which do not itch or cause discomfort but are cosmetically concerning. Unlike common skin blemishes or allergic reactions, xanthelasma is persistent and tends to enlarge or multiply if cholesterol levels remain high. The presence of xanthelasma is associated with an increased risk of atherosclerosis and coronary artery disease.

If you observe yellowish plaques on your eyelids, it’s important to have your cholesterol and heart health evaluated by a healthcare provider. Early detection and management of high cholesterol can help reduce cardiovascular risk. For more information, visit the American Academy of Dermatology’s xanthelasma guide and the American Heart Association’s cholesterol resource.

29. Sudden Hair Loss (Especially on Legs)

Sudden or patchy hair loss, particularly on the legs, can be a sign of poor blood circulation resulting from underlying heart or vascular disease. When arteries become narrowed or blocked due to conditions such as peripheral artery disease (PAD), the reduced blood flow deprives hair follicles of the oxygen and nutrients they need, leading to thinning or loss of hair in affected areas. This type of hair loss is often overlooked because it can occur gradually and may not be immediately associated with heart health.

For example, a person with PAD may notice that the hair on their shins or feet is becoming sparse or disappearing altogether, while the skin appears shiny and thin. Unlike hair loss caused by hormonal changes or aging, circulation-related hair loss typically presents in well-defined patches and may be accompanied by other symptoms such as cool skin, slow-healing sores, or weak pulses in the legs.

If you observe unexplained hair loss on your legs or other extremities, especially in combination with changes in skin color or temperature, consult a healthcare provider for vascular assessment. Early detection can help prevent serious complications. Learn more from the American Heart Association’s resource on peripheral artery disease and the CDC’s PAD information page.

30. Leg Cramps While Walking (Claudication)

Leg cramps that occur during walking or physical activity, known as claudication, can be a sign of reduced blood flow due to arterial blockages, most commonly caused by peripheral artery disease (PAD). In claudication, narrowed or blocked arteries restrict the oxygen supply to leg muscles, resulting in cramping, pain, or heaviness that typically resolves with rest. This symptom is often described as a tight, aching, or burning sensation in the calves, thighs, or buttocks after walking a certain distance.

For instance, someone may notice that after a few minutes of walking, a persistent pain develops in their calves, forcing them to stop and rest. Once they pause, the discomfort subsides, only to return when activity resumes. Unlike muscle cramps from dehydration or overuse, claudication is consistently triggered by exertion and relieved quickly by rest.

If you experience recurring leg cramps or pain during walking, especially if it limits your daily activities, seek medical advice for vascular screening. Early diagnosis of PAD can reduce the risk of serious complications such as ulcers or limb loss. Learn more from the American Heart Association’s guide to PAD and the CDC’s PAD resource.

31. Shiny or Thin Skin on Legs

Chronic circulation problems, such as those associated with peripheral artery disease (PAD) or advanced heart failure, can lead to noticeable changes in the appearance and texture of the skin on the legs. Reduced blood flow deprives the skin of vital nutrients and oxygen, resulting in a shiny, thin, or almost translucent appearance. The skin may also feel cool to the touch and be more prone to injury or slow to heal.

For example, a person with poor circulation in their lower extremities might observe that the skin on their shins or feet develops an unnatural sheen and appears tighter or more fragile than usual. In some cases, hair loss on the legs and a reduction in the number of sweat glands may accompany these skin changes, further highlighting the impact of inadequate blood supply.

It is important to look for other signs of vascular trouble, such as discoloration, ulcers, or decreased pulses in the feet. If you notice your skin becoming unusually shiny, thin, or prone to sores—especially in combination with other symptoms of PAD—seek prompt evaluation by a healthcare provider. For more information, visit the American Heart Association’s PAD resource and the CDC’s information on PAD.

32. Slow-Healing Sores on Feet

Slow-healing sores or ulcers on the feet are a significant warning sign of poor circulation, often resulting from advanced heart or vascular disease such as peripheral artery disease (PAD). When blood flow to the lower extremities is compromised, the delivery of oxygen and nutrients necessary for tissue repair is severely limited, causing even minor wounds to linger or worsen over time. These sores can quickly become infected and lead to more serious complications if not addressed promptly.

For example, a person with PAD may develop a small blister or cut on their foot that fails to heal after several weeks, despite careful attention. The surrounding skin may appear pale, shiny, or cool, and there may be a noticeable lack of hair growth in the area. Unlike wounds that heal within a typical timeframe, these persistent sores require medical investigation to identify and treat the underlying cause.

Prompt care is essential to prevent complications such as infections, tissue death, or even amputation. If you notice a sore on your foot that is slow to heal, especially if you have other risk factors for heart or vascular disease, consult a healthcare professional immediately. Learn more from the American Heart Association’s PAD guide and the CDC’s resource on PAD.

33. Frequent Nosebleeds

Frequent nosebleeds can be more than just a nuisance; they may also signal underlying high blood pressure (hypertension), a key risk factor for heart disease. Elevated blood pressure can weaken and damage the small, delicate blood vessels inside the nose, making them more prone to rupture. While the occasional nosebleed is common and often harmless, especially in dry climates or during allergy season, recurrent or unexplained nosebleeds should prompt further investigation.

For example, a person who rarely experienced nosebleeds in the past might suddenly begin having several episodes a week, often without an obvious cause like trauma or nose picking. These nosebleeds may occur spontaneously, especially during times of stress or physical exertion, and can sometimes be accompanied by headaches or a sensation of pressure in the head.

If you notice a pattern of frequent nosebleeds—particularly if you also experience other symptoms of high blood pressure, such as headaches, dizziness, or blurred vision—it’s important to check your blood pressure regularly. Persistent hypertension can damage your heart and blood vessels over time. For more information, visit the CDC’s high blood pressure resource and the American Heart Association’s guide to hypertension.

34. Voice Changes or Hoarseness

Although uncommon, persistent voice changes or hoarseness can occasionally be linked to heart problems, particularly when the heart becomes enlarged. An enlarged heart, as seen in certain types of heart failure or advanced valve disease, can put pressure on the left recurrent laryngeal nerve, which runs close to the heart and controls the muscles of the voice box (larynx). This pressure can cause a condition known as Ortner’s syndrome, resulting in hoarseness or a weak, breathy voice.

For example, a person with severe mitral valve disease or significant cardiac enlargement might gradually notice their voice growing hoarse or weak, even without symptoms of a respiratory infection or excessive voice use. Unlike temporary hoarseness from a cold or allergies, this type of voice change tends to persist and does not improve with typical remedies.

If you experience ongoing hoarseness or voice changes that last longer than two weeks—especially if you have a history of heart problems or other unexplained symptoms—consult your healthcare provider for a thorough evaluation. Early detection of underlying cardiac causes can be crucial. For more information, visit the Cedars-Sinai guide to Ortner’s syndrome and the American Heart Association’s heart failure resources.

35. Dark Urine

Dark urine can sometimes serve as an indirect sign of heart problems, especially when related to dehydration or reduced kidney function. Heart failure can compromise blood flow to the kidneys, reducing their ability to filter waste and concentrate urine effectively. As a result, urine may become darker in color, ranging from deep yellow to amber or even brown. Additionally, fluid retention in heart failure can paradoxically lead to dehydration, as fluid is trapped in tissues rather than available for bodily functions.

For example, someone with congestive heart failure might notice their urine is consistently darker, even when they are drinking what seems like a normal amount of fluids. Unlike the temporary darkening of urine after exercise, sweating, or consuming certain foods and medications, heart-related dark urine may persist and be accompanied by other symptoms such as swelling, fatigue, or decreased urine output.

To help maintain kidney and heart health, it’s important to monitor urine color and ensure adequate hydration, unless otherwise directed by your doctor for fluid restriction in heart failure. If you experience persistent dark urine, especially alongside swelling or worsening fatigue, seek medical advice. For more, see the American Heart Association’s guide to heart failure symptoms and the CDC’s kidney and heart health resource.

36. Ringing in the Ears (Tinnitus)

Ringing in the ears, or tinnitus, is a common symptom that can sometimes be associated with cardiovascular issues such as high blood pressure or vascular abnormalities. Elevated blood pressure can increase the force of blood flow through the vessels near the inner ear, occasionally leading to a pulsating or persistent ringing sound. Vascular causes of tinnitus may also include atherosclerosis (narrowed arteries) or turbulent blood flow, both of which are risk factors for heart disease.

For example, a person with untreated hypertension might notice a rhythmic “whooshing” or ringing in their ears that becomes more pronounced during periods of stress, physical activity, or when lying down. This sensation differs from the high-pitched ringing caused by loud noise exposure or age-related hearing loss, as it may pulse in time with the heartbeat (pulsatile tinnitus).

If you experience new or persistent ringing in your ears—especially if it pulses with your heartbeat or is accompanied by headaches, dizziness, or high blood pressure readings—consider seeking medical evaluation. A healthcare provider may recommend blood pressure monitoring, hearing tests, or vascular imaging to rule out underlying causes. For more information, see the American Heart Association’s high blood pressure guide and the CDC’s overview of heart disease.

37. Purple or Blue Toe (Blue Toe Syndrome)

A sudden purple or blue discoloration of one or more toes, known as Blue Toe Syndrome, can be a serious sign of underlying heart or vascular disease. This condition often results from cholesterol emboli—tiny fragments of cholesterol plaque—that break off from larger arteries or the heart and travel downstream, blocking the small blood vessels in the toes. The restricted blood flow deprives tissues of oxygen, leading to a bluish or purplish hue that appears suddenly without trauma.

For example, a patient with a history of atherosclerosis or recent cardiac procedure may notice one toe turning blue and becoming painful or cold to the touch. This alarming change may be mistaken for a bruise or simple injury, but in the absence of trauma, it often signifies a vascular emergency. If left untreated, Blue Toe Syndrome can progress to tissue death or even amputation.

Immediate medical evaluation is critical if you notice a toe turning blue or purple, especially if there is associated pain, numbness, or ulceration. Early intervention can help restore blood flow and prevent complications. For further guidance, see the American Heart Association’s report on Blue Toe Syndrome and the National Institutes of Health’s case study on cholesterol embolism.

38. Swelling in Only One Leg

Swelling that occurs in only one leg, rather than both, is often a sign of a localized issue such as a blood clot, known as deep vein thrombosis (DVT). While general swelling in both legs can be related to heart failure, swelling in a single leg can signal a blockage in a deep vein, preventing blood from returning to the heart efficiently. This condition is particularly concerning because DVT increases the risk of life-threatening complications like pulmonary embolism, where a clot travels to the lungs and blocks blood flow.

For example, someone may notice their left calf suddenly becomes swollen, tender, and warm to the touch, while the other leg remains normal. Unlike mild swelling from standing or minor injury, DVT-related swelling is usually more pronounced, persistent, and often associated with pain or a feeling of heaviness.

If you develop sudden, unexplained swelling in one leg—especially if it is accompanied by pain, redness, or warmth—seek emergency medical care without delay. Rapid diagnosis and treatment are essential to prevent complications. For more details, visit the CDC’s information on DVT and the American Heart Association’s guide to venous thromboembolism.

39. Frequent Hiccups with Chest Pain

While persistent hiccups are usually benign, their occurrence alongside chest pain can signal a rare but serious heart issue, such as a heart attack or pericarditis (inflammation of the heart’s lining). The nerves controlling the diaphragm, like the phrenic or vagus nerve, can become irritated by inflammation or compromised blood flow near the heart, triggering recurring hiccups. When this symptom is combined with any form of chest discomfort—whether pressure, tightness, or pain—it may indicate an underlying cardiac emergency.

In one documented case, a middle-aged man experienced relentless hiccups for more than two days, accompanied by mild chest pain and shortness of breath. He initially dismissed his symptoms as stress, but after consulting a doctor, was found to be having a heart attack. The unusual combination of symptoms delayed his diagnosis, highlighting the importance of recognizing this potential warning sign.

If you or someone you know has frequent or persistent hiccups in conjunction with chest pain, shortness of breath, or other heart attack symptoms, seek immediate medical attention. Early intervention can be lifesaving. For more information, visit the Healthline guide to unusual heart attack symptoms and the American Heart Association’s warning signs.

40. Reddened Palms

Reddened palms, known medically as palmar erythema, are characterized by a persistent, sometimes blotchy redness on the palms, particularly over the thenar and hypothenar eminences (the fleshy areas near the base of the thumb and little finger). While palmar erythema is most commonly associated with liver disease, it can also be seen in certain heart conditions, especially those involving chronic heart failure or vascular congestion. The redness results from changes in blood flow and dilation of small blood vessels in the skin.

For example, a person with longstanding heart failure may notice that their palms remain red and warm even when their hands are at rest, and the color does not fade with pressure. Unlike the temporary redness experienced after physical activity or exposure to heat, palmar erythema is persistent and unrelated to recent exertion or temperature changes.

Observing persistent redness on your palms—especially if accompanied by other symptoms like swelling, shortness of breath, or fatigue—warrants a conversation with your healthcare provider for further evaluation. While palmar erythema can have various causes, it should not be ignored if other cardiovascular symptoms are present. For more, visit the National Institutes of Health resource on palmar erythema and the American Heart Association’s heart failure warning signs.

41. Swollen, Painful Big Toe

A swollen, painful big toe is often associated with gout, but it can also signal underlying vascular issues related to heart disease. Gout results from the buildup of uric acid crystals in the joints, and people with heart failure or those taking certain heart medications (such as diuretics) are at increased risk. Additionally, poor circulation from peripheral artery disease (PAD) can reduce blood flow to the extremities, making the big toe more susceptible to inflammation and pain.

For example, a person with congestive heart failure might notice a sudden onset of intense pain, redness, and swelling in their big toe, making it difficult to walk or wear shoes. The pain often develops overnight and may be mistaken for an injury. Unlike minor joint aches or temporary swelling from mild trauma, gout or vascular-related inflammation tends to be severe, persistent, and may recur.

If you experience acute pain and swelling in your big toe, especially if you have a history of heart disease or are on heart medications, consult a healthcare provider for evaluation and management. Early intervention can prevent further complications. For more, read the CDC’s resource on gout and the American Heart Association’s warning signs of heart failure.

42. Flushed Face During Minimal Activity

A flushed or reddened face during minimal activity—such as walking a short distance or performing light household chores—can sometimes be a sign of underlying heart or vascular issues. When the heart struggles to pump efficiently, or when blood pressure rises suddenly, blood vessels in the skin may dilate to accommodate changes in circulation, leading to noticeable redness, especially in the cheeks and forehead. This facial flushing is more pronounced and persistent than the temporary redness that follows strenuous exercise or exposure to heat.

For example, a person with uncontrolled high blood pressure may notice their face turning red and feeling warm after only mild exertion, without feeling overheated elsewhere. Unlike the normal, fleeting blush associated with embarrassment or temperature changes, cardiovascular-related flushing can last longer and may be accompanied by other symptoms such as headaches, palpitations, or dizziness.

Persistent facial flushing during minimal activity—particularly if it occurs with other warning signs like chest discomfort, shortness of breath, or frequent headaches—should prompt a discussion with your healthcare provider and a check of your blood pressure. For more information, visit the CDC’s high blood pressure resource and the American Heart Association’s guide to hypertension.

43. Persistent Metallic Taste

A persistent metallic taste in the mouth, also known as dysgeusia, can sometimes be linked to heart disease. This unusual taste sensation may result from several factors. Certain heart medications—such as ACE inhibitors or diuretics—are known to alter taste perception as a side effect. Additionally, poor circulation caused by heart failure or vascular disease can reduce blood flow to the taste buds and oral tissues, further impacting taste. Dry mouth, another common complication of heart medications or reduced cardiac output, can also intensify a metallic or bitter taste.

For example, a person with chronic heart failure might notice a lingering metallic flavor when eating or drinking, which is not explained by recent dental work or changes in diet. Unlike temporary taste changes from colds or minor infections, this symptom tends to persist as long as the underlying cause remains unaddressed.

If you experience a persistent metallic taste, review your medication list with your healthcare provider and report any new or worsening symptoms, especially if accompanied by other signs of heart or circulatory problems. Adjusting medications or addressing underlying issues can often improve taste disturbances. For more, visit the American Heart Association’s medication guide for heart failure and the Medical News Today’s article on metallic taste causes.

44. Difficulty Swallowing

Difficulty swallowing, medically known as dysphagia, can occasionally be linked to heart or vascular issues. An enlarged heart, particularly due to advanced heart failure or aortic aneurysms, can exert pressure on the esophagus—the muscular tube that carries food from the mouth to the stomach. When this occurs, swallowing may become uncomfortable, painful, or feel as though food is getting stuck in the chest. In some cases, the left atrium of the heart or an enlarged aorta presses directly against the esophagus, causing these symptoms.

For example, a person with severe hypertension or an aortic aneurysm might notice increasing trouble swallowing solid foods, accompanied by a sensation of fullness or chest tightness. Unlike occasional difficulty swallowing related to anxiety, dehydration, or eating too quickly, cardiovascular-related dysphagia is persistent and may gradually worsen over time.

If you develop ongoing or progressively worsening difficulty swallowing—especially if you have a history of heart disease, high blood pressure, or other risk factors—seek medical evaluation promptly. Early assessment can help identify the underlying cause and prevent complications. For more information, consult the Cedars-Sinai resource on aortic aneurysm and the American Heart Association’s heart failure guide.

45. Persistent Hiccups After Eating

Persistent hiccups that occur after eating may seem like a harmless annoyance, but in some cases—especially in individuals with heart disease—they can indicate underlying circulatory or nerve involvement. After meals, increased blood flow is directed to the digestive tract. In people with compromised heart function, this shift can cause congestion or mild swelling near the diaphragm, irritating the phrenic or vagus nerves that control the hiccup reflex. This irritation can trigger ongoing hiccups that last well beyond the typical brief episodes experienced by most people.

For example, someone with heart failure might find themselves hiccupping for several minutes or even hours after eating a moderate meal, even if they avoid carbonated drinks or eating too quickly. Unlike transient hiccups caused by overeating or spicy foods, heart-related persistent hiccups are more likely to recur, especially after larger meals or when lying down.

If you notice persistent hiccups after eating—particularly if you have other heart symptoms like swelling, fatigue, or breathlessness—keep a diary of when they occur and discuss the pattern with your healthcare provider. Early recognition can help uncover heart-related complications. For more, visit the American Heart Association’s warning signs of heart failure and the Healthline guide to unusual heart symptoms.

46. Drooping Eyelid (Ptosis)

A drooping eyelid, medically known as ptosis, can rarely be linked to vascular problems associated with heart disease. When blood flow to the nerves controlling the muscles of the eyelid is compromised—such as from a carotid artery dissection or other vascular abnormalities—nerve function can be impaired, leading to sudden or gradual eyelid drooping. While ptosis is more commonly due to neurological or muscular disorders, its sudden onset, particularly alongside other neurological symptoms, may indicate a vascular emergency.

For example, a person with undiagnosed carotid artery disease may notice that one eyelid suddenly sags and is difficult to lift, sometimes accompanied by headache, facial pain, or changes in vision. This scenario could represent Horner’s syndrome, a condition that can occur when blood flow to specific nerves is disrupted by a vascular event such as a carotid artery dissection—an urgent medical condition often linked to increased risk of stroke or heart complications.

If you experience a sudden drooping eyelid—especially if it’s accompanied by facial weakness, slurred speech, or vision changes—seek emergency medical care immediately. Prompt evaluation is essential for identifying vascular or cardiac causes. For more information, refer to the National Institutes of Health resource on Horner’s syndrome and the American Heart Association’s stroke warning signs.

47. Yellowing of the Skin (Jaundice)

Yellowing of the skin and the whites of the eyes, known as jaundice, can sometimes be a sign of advanced heart disease, particularly right-sided heart failure. When the right side of the heart struggles to pump blood efficiently, blood can back up into the liver, causing congestion and impaired liver function. This congestion can lead to the buildup of bilirubin—a yellow pigment normally processed by the liver—which then accumulates in the skin and eyes, resulting in jaundice.

For example, a person with longstanding heart failure may notice a gradual yellowing of their skin, darkening of their urine, and discomfort or swelling in the upper right side of the abdomen. Unlike jaundice caused strictly by liver disease or hepatitis, heart-related jaundice is often accompanied by other symptoms of fluid overload, such as swelling in the legs, ascites (abdominal swelling), or shortness of breath.

If you observe yellowing of the skin or eyes—especially if you have a history of heart failure or notice additional symptoms like fatigue, swelling, or abdominal discomfort—promptly consult your healthcare provider. Early evaluation can help determine the cause and guide appropriate treatment. Learn more at the American Heart Association’s heart failure warning signs and the CDC’s information on jaundice.

48. Sudden Vision Changes

Sudden changes in vision—such as blurriness, partial loss of sight, or seeing flashes of light—can be a warning sign of serious cardiovascular issues. Vascular blockages, such as those caused by blood clots or cholesterol emboli, can disrupt blood flow to the retina or optic nerve, leading to rapid and often dramatic changes in eyesight. Similarly, extremely high blood pressure (hypertensive crisis) can cause damage to the small blood vessels in the eyes, resulting in swelling, bleeding, or even retinal detachment.

For example, a person with uncontrolled hypertension or atrial fibrillation may experience a sudden episode where they lose vision in one eye or notice a shadow or curtain descending over their field of view. This alarming symptom can come on without pain and may be mistaken for simple eye strain or fatigue, but it usually indicates a vascular emergency—such as a retinal artery occlusion or stroke.

Any sudden or unexplained vision change should be treated as a medical emergency. Immediate evaluation by a healthcare provider or emergency services can help prevent permanent vision loss or life-threatening complications. For more information, visit the American Heart Association’s stroke warning signs and the CDC’s guide to heart disease symptoms.

49. Ear Lobe Crease (Frank’s Sign)

A diagonal crease running across the earlobe, known as Frank’s Sign, has been observed in various studies as a potential physical marker of increased heart disease risk. First described by Dr. Sanders T. Frank in 1973, this crease is most often seen as a deep, diagonal line extending from the ear canal to the edge of the earlobe. While the exact mechanism remains unclear, some researchers suggest that changes in small blood vessels supplying the ear may mirror the arterial changes associated with atherosclerosis.

Research has yielded mixed results: some studies have found a higher prevalence of coronary artery disease among individuals with ear lobe creases, while others have found no direct causal relationship. The presence of Frank’s Sign is most significant when paired with traditional cardiovascular risk factors, such as high blood pressure, smoking, or high cholesterol.

If you notice a diagonal crease in your earlobe, it’s worth using this as a prompt to check in on your heart health, especially if you have other risk factors or symptoms. However, this sign alone does not confirm or rule out heart disease. For additional context, see the National Institutes of Health’s review on Frank’s Sign and the American Heart Association’s cardiovascular disease overview.

50. Unexplained Anxiety or Sense of Doom

Unexplained anxiety or an overwhelming sense that something is terribly wrong—often described as a “sense of doom”—can sometimes be an early warning sign of a heart attack or other cardiac event. During a heart attack, the body releases a surge of stress hormones in response to pain, reduced oxygen, or tissue injury, which can trigger feelings of panic, agitation, or intense fear. This psychological warning may appear with or even before classic symptoms such as chest pain, shortness of breath, or sweating.

For example, a patient experiencing a heart attack recalled feeling a profound sense of anxiety and impending doom, even before chest discomfort began. She reported a sudden, inexplicable feeling that something was “very wrong” and was compelled to seek help, which ultimately saved her life. These emotional symptoms can be especially misleading if the physical signs are mild or absent.

If you or someone you know experiences sudden, intense anxiety without a clear cause—especially if accompanied by chest discomfort, nausea, or shortness of breath—seek emergency medical attention immediately. Early intervention is critical for survival. Learn more at the American Heart Association’s heart attack warning signs and the CDC’s heart disease symptoms page.

Conclusion

Recognizing the body’s unusual signals can be lifesaving when it comes to heart health. Subtle or strange symptoms—often dismissed as minor or unrelated—may be early warnings of serious cardiovascular problems. Early detection improves outcomes, making it crucial to stay alert to these changes. Practical steps include scheduling regular heart screenings, openly discussing any new or persistent symptoms with your healthcare provider, and considering wearable heart monitors for ongoing tracking. Proactive care and timely intervention can help prevent complications and support long-term well-being. For more on heart health and prevention, visit the CDC’s prevention guide and the American Heart Association’s Life’s Essential 8.

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