Vitamin B12 deficiency affects approximately 6% of people under 60 in the U.S. and up to 20% of those over 60, with similar rates in the U.K. as of 2023 (NIH, NHS). The deficiency primarily impacts the nervous and hematological systems. Unusual symptoms often lead to missed or delayed diagnosis, posing significant challenges for patients and healthcare providers alike.
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26. Darkened Skin Patches Vitamin B12 deficiency can cause unusual skin pigmentation changes, including the development of darkened skin patches or hyperpigmentation. These changes are most…