Health

Long COVID: Scary New Symptoms Emerge

47. New-Onset Depression A growing concern in the aftermath of COVID-19 is new-onset depression among individuals with no prior mental health history. This can be attributed… Alina Yasinskaya - July 22, 2025

Long COVID has become a persistent public health concern as we move through 2023 and 2024. Recent data from the UK’s Office for National Statistics estimates that nearly 1.9 million people in the UK are experiencing long-term symptoms, while the CDC reports that about 6% of adults in the US have had Long COVID at some point ONS CDC. Long COVID can impact the brain, heart, lungs, and other organs.
A critical challenge is that symptoms often emerge late, making detection and treatment even more difficult.

1. Unexplained Seizures

1. Unexplained Seizures
A detailed brain scan highlights areas of inflammation, providing crucial insight for neurologists investigating seizure disorders. | Generated by Google Gemini

One of the most alarming new symptoms emerging among Long COVID sufferers is the onset of unexplained seizures. These neurological disruptions can manifest months after an initial COVID-19 infection, even in those with no prior history of epilepsy or seizure disorders. Medical experts believe that ongoing inflammation, immune system overactivity, or disrupted brain signaling may play a critical role in triggering this frightening symptom.
A case documented in the National Institutes of Health highlights a previously healthy individual developing recurrent seizures and confusion weeks after recovering from mild COVID-19. Such episodes can range from brief, subtle lapses in attention to full-blown convulsions and loss of consciousness.
Warning signs to watch for include sudden muscle jerks, persistent confusion, unexplained blackouts, or episodes of staring and unresponsiveness. If you or someone you know experiences any of these symptoms following a COVID-19 infection, it is crucial to seek immediate medical attention. Early intervention and neurological evaluation can make a significant difference in managing and potentially reducing seizure risk associated with Long COVID.

2. Sudden Hearing Loss

2. Sudden Hearing Loss
A patient sits quietly as an audiologist gently places headphones over their ear for a routine hearing test. | Generated by Google Gemini

Long COVID’s reach into the nervous system includes a surprising and distressing symptom: sudden hearing loss. Some patients, months after their initial infection, report rapid-onset hearing deficits that cannot be explained by age, noise exposure, or pre-existing conditions. Researchers suspect that the virus can inflame or damage the delicate structures of the inner ear, much like other viral infections such as mumps and measles, which are known causes of sensorineural hearing loss NIH.
The sudden nature of this hearing loss is particularly concerning. Patients may describe waking up to muffled sounds, ringing (tinnitus), or difficulty understanding speech. In some cases, hearing is lost in one ear without warning and may not return without prompt treatment. These symptoms can severely disrupt daily life and professional functioning.
Audiologists and otolaryngologists recommend early audiological screening for anyone experiencing hearing changes after COVID-19. Early intervention with medications or specialized therapies may help recover some or all hearing if addressed quickly. If you notice abrupt changes in your hearing, do not delay seeking professional evaluation—timely action is critical to prevent permanent deficits.

3. Irregular Heart Rhythms

3. Irregular Heart Rhythms
A detailed ECG printout displays the intricate patterns of heart rhythm, highlighting vital aspects of cardiovascular health. | Generated by Google Gemini

Long COVID is increasingly being recognized for its impact on the cardiovascular system, particularly in the form of irregular heart rhythms (arrhythmias). Persistent inflammation can irritate the heart muscle and electrical pathways, sometimes resulting in symptoms that closely resemble post-viral myocarditis, a condition known to follow other viral infections like influenza and Coxsackievirus. These arrhythmias may present as palpitations, skipped beats, or even episodes of rapid or pounding heartbeats, which can feel frightening and unpredictable.
According to the American Heart Association, patients with Long COVID are at a higher risk for developing both atrial and ventricular arrhythmias, even if they had no previous heart conditions. Some individuals have reported dizziness, fainting spells, chest pain, or shortness of breath as initial warning signs. These red flags should never be ignored.
Cardiac specialists strongly recommend ongoing cardiac monitoring if you experience any of these symptoms post-COVID, especially if they occur at rest or during minimal activity. Early detection of arrhythmias through EKGs or wearable monitors can be life-saving and help prevent more severe complications down the road.

4. New Onset Diabetes

4. New Onset Diabetes
A person checks their blood sugar with a glucose meter, insulin pen and supplies neatly arranged beside them. | Generated by Google Gemini

A concerning trend among Long COVID patients is the emergence of new onset diabetes after infection. Scientists suspect that the SARS-CoV-2 virus may directly attack or inflame the insulin-producing beta cells in the pancreas, leading to impaired glucose regulation. This mechanism is not unique to COVID-19; other viral infections have historically triggered diabetes in certain individuals, as seen with enteroviruses and mumps NIH.
Recent studies from the CDC have found that people recovering from COVID-19—especially those with severe or prolonged symptoms—are at a higher risk for both type 1 and type 2 diabetes. Symptoms such as increased thirst, frequent urination, unexplained weight loss, or persistent fatigue can all signal abnormal blood sugar levels.
Doctors urge those recovering from COVID-19 to monitor for these symptoms and consider routine glucose checks, especially if risk factors for diabetes are present. Early detection and management are crucial to minimize long-term health complications. If you notice any warning signs, consult your healthcare provider for evaluation and testing.

5. Sudden Vision Changes

5. Sudden Vision Changes
A close-up view of an eye undergoing a vision test, with the retina clearly visible under bright examination light. | Generated by Google Gemini

Long COVID has also been linked to sudden vision changes—a troubling and often unexpected complication. Researchers believe that microvascular injury, or damage to the small blood vessels in the eye, may underlie these symptoms. This type of injury can cause retinal inflammation or bleeding, leading to blurred vision, dark spots, or even partial loss of sight. These complications are, in some ways, similar to what is seen in diabetic retinopathy, where chronically high blood sugar damages the eye’s delicate vessels NIH.
Some Long COVID patients have reported experiencing flashes of light, sudden floaters, or a shadow or curtain over part of their vision. Such symptoms can appear rapidly and may indicate an emergency, such as retinal detachment or severe inflammation.
Ophthalmologists urge anyone recovering from COVID-19 to remain vigilant for visual disturbances. Prompt consultation with an eye specialist is essential if you experience any sudden changes in vision. Early intervention can help preserve sight and prevent permanent damage, emphasizing the need for proactive eye health monitoring in Long COVID cases.

6. Severe Muscle Weakness

6. Severe Muscle Weakness
A determined patient works with a physical therapist, battling muscle weakness and fatigue through guided rehabilitation exercises. | Generated by Google Gemini

Many Long COVID patients are reporting severe muscle weakness that lingers for months after their initial infection. Scientists point to persistent muscle inflammation and possible mitochondrial dysfunction, where the body’s cells struggle to produce enough energy for normal function. This results in profound fatigue, muscle pain, and the sensation that even light activities are exhausting. These symptoms closely resemble those of chronic fatigue syndrome (CFS), a condition known for its debilitating and long-term impact on quality of life NIH.
Individuals may struggle with basic daily tasks such as walking, climbing stairs, or even lifting small objects. In some cases, patients describe muscle tremors or a sense of heaviness that is disproportionately severe compared to the level of exertion. This weakness can be both physically and emotionally draining, often leading to frustration and anxiety.
Medical professionals recommend considering physical therapy or rehabilitation programs if muscle weakness persists beyond a few weeks. Targeted exercise and supportive therapies can help rebuild strength and improve function over time. If weakness is severe or worsening, it’s important to consult a healthcare provider for assessment and personalized management.

7. Persistent Skin Rashes

7. Persistent Skin Rashes
A close-up view of an autoimmune skin rash reveals red, inflamed patches examined by a dermatology specialist. | Generated by Google Gemini

A surprising but increasingly documented symptom among Long COVID sufferers is the development of persistent skin rashes. These skin changes are thought to be immune-mediated, meaning the body’s immune system continues to react long after the virus is gone. Patients describe a variety of rashes: from raised, red patches to purplish, lace-like patterns. In some cases, the rashes resemble those seen in autoimmune diseases such as lupus, with distinctive facial or body patterns American Academy of Dermatology.
The rashes may be itchy, painful, or even accompanied by swelling and peeling. Some individuals find that their skin symptoms flare up during periods of stress or fatigue, while others notice no obvious triggers. These persistent skin reactions can last for weeks or months, causing discomfort and concern for those affected.
Dermatologists recommend seeking a professional evaluation if a Long COVID-related rash is widespread, persistent, or associated with other symptoms like fever or joint pain. Prompt dermatological consultation helps ensure accurate diagnosis and tailored treatment, which may include topical or oral medications to reduce inflammation and improve skin health.

8. Unusual Blood Clotting

8. Unusual Blood Clotting
A detailed illustration shows a blood clot forming inside a blood vessel, highlighting the process of vascular thrombosis. | Generated by Google Gemini

Another alarming complication seen in Long COVID is the emergence of unusual blood clotting disorders. Research has shown that some patients develop a heightened risk of forming clots, long after they have cleared the initial infection. The phenomenon is believed to be related to ongoing inflammation and immune dysregulation, which can disrupt normal blood flow and clotting mechanisms. Studies have documented an increased incidence of deep vein thrombosis (DVT), pulmonary embolism, and other clotting events in those recovering from COVID-19 NIH.
Symptoms of a potential clot include sudden swelling, redness, warmth, or pain in a limb (often the leg), as well as chest pain, difficulty breathing, or coughing up blood. These are medical emergencies that require urgent evaluation and intervention.
Healthcare providers stress the importance of monitoring for these red flags in the months following COVID-19, especially for those with a history of clotting disorders, immobility, or underlying cardiovascular conditions. Early identification and treatment with blood thinners can prevent life-threatening complications, underscoring the need for vigilance in Long COVID recovery.

9. Debilitating Headaches

9. Debilitating Headaches
A neurologist examines detailed brain scans, searching for clues to the cause of a persistent headache. | Generated by Google Gemini

Long COVID has been linked to debilitating headaches that can linger for weeks or months, severely impacting daily functioning. These headaches are often attributed to neuroinflammation—an ongoing irritation of the nerves and tissues in the brain. The pain can be intense, throbbing, or pressure-like, and frequently mimics migraines or the persistent discomfort experienced after a concussion (post-concussion syndrome). Some patients report sensitivity to light and sound, nausea, or even visual disturbances during headache episodes NIH.
Unlike typical tension headaches, Long COVID headaches often resist standard pain medications and may escalate in severity over time. This can cause significant distress, interfere with work or school, and lead to sleep disturbances or mood changes.
Neurologists advise that further neuroimaging—such as MRI or CT scans—should be considered if headaches are unusually severe, sudden in onset, or accompanied by neurological symptoms like weakness, confusion, or vision loss. Timely diagnosis is essential to rule out more serious complications such as blood clots or brain inflammation, allowing for targeted interventions to manage pain and prevent long-term consequences.

10. Difficulty Swallowing

10. Difficulty Swallowing
A speech therapist gently guides a patient through swallowing exercises, highlighting the importance of throat strength and communication. | Generated by Google Gemini

An often-overlooked but deeply unsettling symptom of Long COVID is difficulty swallowing, medically known as dysphagia. This complication arises when the nerves or muscles that coordinate swallowing become disrupted—likely due to lingering inflammation or direct viral injury to the cranial nerves that control these functions. Such nerve involvement is reminiscent of what occurs in post-stroke patients, where dysphagia is a common and potentially dangerous complication NIH.
Long COVID patients may experience a sensation of food “getting stuck,” coughing or choking during meals, or a persistent sore throat. These symptoms can increase the risk of aspiration (food or liquid entering the airway), leading to pneumonia and nutritional deficiencies. Swallowing difficulties can also cause anxiety and make social eating situations challenging.
Experts strongly recommend early intervention with a speech-language pathologist if swallowing problems persist or worsen. Specialized swallowing therapy and exercises can help retrain muscles, reduce risk, and improve quality of life. If you or a loved one experiences new-onset dysphagia after COVID-19, prompt medical evaluation is vital to ensure safety and effective management.

11. New Food Allergies

11. New Food Allergies
A doctor carefully applies allergy testing drops to a patient’s forearm, illustrating how the immune system reacts to food allergens. | Generated by Google Gemini

A surprising phenomenon reported by some Long COVID patients is the development of new food allergies after their initial infection. Scientists suspect that COVID-19 can cause lasting dysregulation of the immune system, making it more prone to inappropriate reactions against harmless substances—such as certain foods. This process is not entirely new; other viral illnesses have also been linked to the onset of food allergies, particularly in children NIH.
Individuals may notice hives, swelling, stomach pain, or even difficulty breathing after consuming foods that previously caused no issues. In some cases, reactions can be severe and rapid, resembling classic allergic responses. The sudden appearance of food allergies can be both confusing and frightening, impacting daily eating habits and nutrition.
Allergy and immunology specialists emphasize the importance of allergy testing if you develop new symptoms after COVID-19. Skin prick tests or blood tests can help identify specific allergens and guide safe dietary choices. Prompt consultation is crucial, especially if you have experienced any signs of anaphylaxis. Management may include avoidance strategies, emergency medications, and ongoing monitoring by a healthcare provider.

12. Sleep Paralysis

12. Sleep Paralysis
A person lies wide-eyed in bed, seemingly trapped between wakefulness and sleep, capturing the unsettling grip of sleep paralysis during REM sleep. | Generated by Google Gemini

Another unsettling symptom reported by some Long COVID sufferers is sleep paralysis—a temporary inability to move or speak while falling asleep or waking up. This phenomenon is thought to result from disruptions in the REM (rapid eye movement) sleep cycle, where the brain is active but the body’s muscles remain relaxed. The experience can be terrifying, often accompanied by vivid hallucinations or a sense of pressure on the chest. Scientists draw comparisons to narcolepsy, a neurological disorder also characterized by frequent disturbances in REM sleep Sleep Foundation.
While episodes of sleep paralysis are not dangerous in themselves, they can lead to significant anxiety and disrupt overall sleep quality. Repeated episodes may contribute to chronic sleep deprivation, fatigue, and mood changes—further compounding the challenges of Long COVID recovery.
Experts recommend adopting sleep hygiene techniques to minimize the risk of sleep paralysis. These include maintaining a consistent sleep schedule, creating a restful environment, reducing screen time before bed, and managing stress through relaxation exercises. If symptoms persist or are particularly distressing, consulting a sleep specialist can help identify underlying issues and guide more targeted treatment strategies.

13. Severe Tinnitus

13. Severe Tinnitus
A close-up of a person’s ear with a digital audiology graph overlay, highlighting the experience of tinnitus. | Generated by Google Gemini

A distressing and persistent symptom reported by Long COVID patients is severe tinnitus—a constant or intermittent ringing, buzzing, or hissing in the ears. This condition is believed to arise from inflammation or injury to the auditory nerve, which disrupts normal sound processing. The sensation can be subtle or overwhelming, sometimes accompanied by hearing loss or dizziness. This is reminiscent of disorders like Ménière’s disease, where inner ear dysfunction leads to similar auditory disturbances NIH.
Tinnitus can interfere with concentration, sleep, and emotional well-being. For many, the unrelenting noise becomes a source of anxiety or depression, as it may persist for months and resist standard treatments. Environmental factors such as stress, fatigue, or exposure to loud sounds can exacerbate symptoms.
Audiologists recommend prompt evaluation for anyone experiencing new or worsening tinnitus after COVID-19. Early intervention may include sound therapy, hearing aids, or counseling to help manage distress. If tinnitus is severe, accompanied by hearing changes, or affects daily functioning, seeing a hearing specialist is essential for accurate diagnosis and tailored management strategies.

14. Sudden Hair Loss

14. Sudden Hair Loss
A dermatologist gently examines a patient’s scalp, highlighting the careful assessment involved in diagnosing hair loss and alopecia. | Generated by Google Gemini

A striking consequence of Long COVID for some individuals is sudden hair loss, often occurring weeks to months after the initial infection. This phenomenon, known as telogen effluvium, is a form of diffuse hair shedding triggered by significant physiological stress or immune disturbances. The body pushes more hair follicles than usual into the resting (telogen) phase, resulting in increased shedding and noticeable thinning. This is similar to stress-induced alopecia, where emotional or physical trauma leads to temporary hair loss American Academy of Dermatology.
The hair loss can be sudden and alarming, with clumps of hair coming out during washing or brushing. While not dangerous, the visible effect can be distressing and impact self-esteem. Many people worry that the hair loss may be permanent, but in most cases, hair regrowth occurs as the body recovers.
Supportive treatments include gentle hair care, minimizing heat and chemical exposure, and ensuring a balanced diet rich in protein, vitamins, and minerals. Dermatologists may recommend supplements or topical treatments in severe cases. If hair loss persists or worsens, consulting a healthcare provider can help rule out other causes and provide reassurance.

15. Chronic Nausea

15. Chronic Nausea
A detailed illustration of the digestive system highlights the stomach, visually representing the sensation of nausea and discomfort. | Generated by Google Gemini

A perplexing symptom for many Long COVID sufferers is chronic nausea, which may persist for months and significantly disrupt daily life. Researchers believe that ongoing inflammation or immune system misfiring can disrupt the gut-brain axis—the complex network linking the digestive tract and nervous system. This disruption may slow stomach emptying and lead to symptoms similar to post-viral gastroparesis, a condition where the stomach muscles don’t work properly after an infection NIH.
Patients often describe unrelenting queasiness, early satiety, bloating, or even vomiting after modest meals. The sensation can be constant or flare up unpredictably, making it difficult to maintain adequate nutrition or hydration. In many cases, typical remedies for mild nausea provide little relief.
It’s important to watch for red flags that warrant prompt gastrointestinal (GI) consultation, such as significant weight loss, persistent vomiting, blood in vomit or stool, or severe abdominal pain. Early evaluation by a GI specialist can lead to targeted treatments, including dietary adjustments, medications to enhance gut motility, and strategies to manage nausea. Addressing these symptoms early can prevent more serious complications and improve overall quality of life.

16. Chest Pain Not From Heart

16. Chest Pain Not From Heart
A concerned man clutches his chest while sitting on a couch, highlighting the importance of recognizing musculoskeletal chest pain as a health warning. | Generated by Google Gemini

Many Long COVID patients experience chest pain that is not related to heart or lung disease—a symptom that can be both distressing and confusing. This pain often arises from musculoskeletal inflammation or nerve involvement in the chest wall, rather than from cardiac origins. The sensation is frequently described as sharp, aching, or pressure-like, and may worsen with movement, deep breaths, or palpation. This pattern is similar to costochondritis, an inflammation of the cartilage connecting the ribs to the breastbone.
Unlike heart-related pain, this type typically remains localized and can persist for weeks or months. Some patients also report tingling, numbness, or “electric shock” sensations radiating along the chest or ribs, suggesting nerve irritation. While not usually dangerous, the symptom can cause significant anxiety and impact daily functioning.
It is essential, however, to rule out heart or lung problems whenever new or severe chest pain occurs, especially if accompanied by shortness of breath, palpitations, dizziness, or sweating. If these red flags are present, seek immediate medical evaluation. Once serious causes are excluded, targeted pain management and physical therapy can help alleviate discomfort.

17. Burning Sensations

17. Burning Sensations
A close-up of a hand glowing with fiery red highlights, symbolizing the intense burning sensation of nerve pain in neuropathy. | Generated by Google Gemini

A troubling Long COVID symptom reported by many is the experience of burning sensations in various parts of the body, particularly in the hands, feet, or limbs. This symptom points to nerve irritation or neuropathy, where the nerves become inflamed or damaged by the lingering effects of the virus or the immune response. The sensation may be described as “pins and needles,” tingling, or an intense, burning pain that can persist for weeks or months NIH.
This type of neuropathic pain bears resemblance to the discomfort experienced during shingles (herpes zoster), where viral reactivation causes inflammation and pain along nerve pathways. Unlike shingles, however, these burning sensations in Long COVID are not usually accompanied by a skin rash, which can make diagnosis more challenging.
Experts recommend seeking a neurology evaluation if burning, tingling, or numbness is persistent, worsening, or accompanied by muscle weakness or balance problems. Neurologists can perform specialized nerve tests and may suggest medications or therapies to reduce nerve pain and improve quality of life. Early assessment is key to ruling out other causes and initiating appropriate treatment.

18. Unexplained Weight Loss

18. Unexplained Weight Loss
A colorful assortment of fresh fruits, leafy greens, and lean proteins arranged on a plate, symbolizing balanced nutrition for healthy weight loss and metabolism. | Generated by Google Gemini

A particularly worrisome symptom in some Long COVID cases is unexplained weight loss. This can occur even when patients are eating enough, suggesting that metabolic changes and chronic inflammation may be at play. The body’s ongoing immune response to the virus can increase energy demands and alter how nutrients are processed, leading to unintentional weight loss over weeks or months. In severe cases, this pattern resembles cancer cachexia, where inflammation and metabolic changes cause muscle wasting and significant loss of body mass.
Patients might notice their clothes becoming looser, a decline in muscle tone, or fatigue and weakness even with normal intake. This type of weight loss can undermine the body’s ability to recover, impair immune function, and increase vulnerability to other illnesses.
Healthcare providers recommend seeking a nutritional assessment if you experience significant or persistent weight loss after COVID-19. Registered dietitians can offer tailored advice, meal planning, and supplements to help stabilize weight and promote healing. If weight loss is rapid, accompanied by gastrointestinal symptoms, or causing concern, prompt medical evaluation is crucial to identify underlying causes and prevent complications.

19. Difficulty Speaking

19. Difficulty Speaking
A neurologist explains speech pathways using a brain diagram, highlighting areas affected by aphasia in patients. | Generated by Google Gemini

Long COVID can also manifest as difficulty speaking, which may be subtle or quite pronounced. This symptom can arise from both cognitive and muscular impacts—some patients find their thoughts are slow to form into words, while others experience slurred or weak speech due to muscle fatigue. These issues are reminiscent of post-stroke aphasia, where damage to specific brain regions impairs the ability to express or understand language National Institute on Deafness and Other Communication Disorders.
Individuals might struggle to find the right words, forget common vocabulary, or become easily overwhelmed during conversation. Speech may trail off, sound hoarse, or require more effort than usual. Such challenges can be deeply frustrating and may cause people to withdraw from social interactions, compounding the emotional toll of Long COVID.
Experts recommend seeking early speech therapy if you notice persistent changes in speech, language, or communication. Speech-language pathologists can provide tailored exercises and strategies to rebuild strength, improve clarity, and boost confidence. Prompt intervention gives the best chance for recovery and helps prevent further isolation or decline in communication skills.

20. New or Worsening Anxiety

20. New or Worsening Anxiety
A young woman sits alone on a couch, clutching her knees as stress and anxiety cloud her expression. | Generated by Google Gemini

For many Long COVID patients, new or worsening anxiety has emerged as a significant and persistent challenge. Scientists believe that changes in neurotransmitter balance—chemicals like serotonin and dopamine that regulate mood—may be disrupted by ongoing inflammation or immune activation in the brain. This altered brain chemistry can trigger anxiety symptoms that are intense, unpredictable, and resistant to usual coping strategies. In some cases, these experiences are comparable to post-traumatic stress disorder (PTSD), where traumatic events lead to lasting psychological distress NIH.
Patients may report constant worry, panic attacks, restlessness, or a sense of impending doom. These symptoms can interfere with sleep, relationships, and overall quality of life. The uncertainty and unpredictability of Long COVID itself may worsen anxiety, creating a difficult cycle to break.
Mental health professionals emphasize the importance of seeking mental health support if anxiety is persistent, worsening, or interfering with daily function. Therapy, medication, mindfulness techniques, and support groups can all play a role in recovery. Early intervention is key to managing symptoms and restoring emotional resilience during the long and unpredictable course of Long COVID.

21. Persistent Shortness of Breath

21. Persistent Shortness of Breath
A detailed illustration of damaged lungs highlights the scarring caused by pulmonary fibrosis, explaining symptoms like shortness of breath. | Generated by Google Gemini

One of the most troubling symptoms for Long COVID patients is persistent shortness of breath, which can linger long after the initial infection. Researchers have found that this symptom may be linked to lung scarring (fibrosis) or the formation of microclots in the tiny vessels of the lungs, both of which can impair oxygen exchange. This situation is similar to pulmonary fibrosis, a condition where scar tissue accumulates in the lungs and makes breathing increasingly difficult CDC.
Patients may notice difficulty catching their breath with even mild exertion, persistent coughing, or chest tightness. These symptoms can significantly impact daily activities and quality of life, causing frustration and anxiety.
Pulmonologists recommend requesting pulmonary function tests if you experience ongoing shortness of breath, especially if it does not improve with time or is accompanied by low oxygen levels, chest pain, or palpitations. These tests can assess lung capacity, oxygen exchange, and identify any underlying damage. Early evaluation and intervention are crucial to prevent further lung impairment and develop effective treatment strategies for Long COVID respiratory complications.

22. Loss of Taste and Smell (Prolonged)

22. Loss of Taste and Smell (Prolonged)
A young woman sits at a kitchen table, puzzled, as she sniffs a lemon and tastes soup with no reaction. | Generated by Google Gemini

A hallmark of COVID-19, the loss of taste and smell, can persist for months or even longer in some Long COVID patients. This prolonged sensory loss is believed to be due to ongoing nerve damage, where the olfactory and gustatory nerves remain inflamed or fail to regenerate properly. The experience is similar to sensory changes seen after chemotherapy, where nerve injury can dull or distort taste and smell for extended periods NIDCD.
The inability to enjoy food, detect smoke, or sense spoiled food can have a profound impact on nutrition, safety, and psychological well-being. Some individuals experience altered smells (parosmia) or phantom tastes, which can be particularly distressing.
Experts suggest sensory retraining as a promising approach for recovery. Strategies include daily “smell training” with strong scents like citrus, cloves, or eucalyptus, along with mindful tasting of foods with varied textures and flavors. Maintaining good oral and nasal hygiene, staying hydrated, and using flavor enhancers may also help. If loss of taste or smell persists beyond several months, consultation with an ENT specialist is recommended to explore advanced therapies and rule out other causes.

23. Severe Joint Pain

23. Severe Joint Pain
A pair of hands gently massaging a swollen, inflamed joint, highlighting the discomfort of arthritis and persistent pain. | Generated by Google Gemini

A growing number of Long COVID patients are experiencing severe joint pain that is often immune-triggered. The immune system, in its overactive or misdirected state post-infection, may attack the lining of the joints, leading to pain, swelling, and stiffness. This process closely resembles rheumatoid arthritis, an autoimmune condition where the immune system targets joint tissue.
Symptoms can flare unpredictably, affecting multiple joints—commonly the hands, knees, ankles, or shoulders. The pain may be worse in the morning or after periods of rest, and can significantly limit mobility and daily activities. Some patients also report warmth or redness around the affected joints, further mimicking autoimmune arthritis.
Rheumatologists recommend considering a rheumatology evaluation if joint pain is severe, persistent, or associated with swelling, redness, or fever. Early assessment can help distinguish between post-viral arthritis and other causes, and enable timely interventions with medications or physical therapy. Left untreated, severe joint inflammation can lead to lasting damage, making early specialist involvement essential for long-term joint health and function.

24. Brain Fog (New Cognitive Decline)

24. Brain Fog (New Cognitive Decline)
A person sits at a desk, surrounded by swirling clouds, symbolizing brain fog and struggles with memory and focus. | Generated by Google Gemini

Perhaps one of the most widely reported and frustrating symptoms of Long COVID is brain fog—a form of new cognitive decline. Researchers believe this phenomenon is driven by persistent neuroinflammation and disrupted neurotransmitter pathways that impair memory, focus, and mental clarity. This cognitive dysfunction is similar to “chemo brain,” a condition experienced by cancer patients after chemotherapy, where attention, processing speed, and recall are compromised NIH.
Patients with Long COVID may find themselves forgetting appointments, losing track of conversations, or struggling to concentrate on tasks that once felt routine. These issues can significantly impact work, relationships, and self-confidence, causing both practical and emotional distress.
Experts recommend several cognitive rehabilitation strategies to help manage brain fog. These include keeping a structured daily routine, using written reminders, breaking tasks into smaller steps, and practicing mindfulness or meditation to reduce stress. Regular physical activity and brain-training exercises, such as puzzles or memory games, can also support recovery. If symptoms are severe or worsening, consulting a neurologist or cognitive rehabilitation specialist may provide additional tools and guidance for regaining mental sharpness.

25. Chronic Fatigue (Extreme)

25. Chronic Fatigue (Extreme)
A woman sits slumped on a couch in soft afternoon light, her face weary with chronic exhaustion and drained energy. | Generated by Google Gemini

Arguably the most debilitating and pervasive complaint among Long COVID sufferers is chronic fatigue—a profound exhaustion that does not improve with rest. Scientists believe this extreme fatigue is a result of ongoing inflammation and mitochondrial dysfunction, where the body’s energy-producing cells are unable to meet normal demands. This symptom closely mirrors myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a complex condition marked by persistent, unexplained fatigue and post-exertional malaise CDC.
Patients often describe feeling “wiped out” by even minor activities, with energy levels that fluctuate unpredictably. Attempts to push through fatigue can trigger “crashes” that last for days or weeks, significantly impacting work, family life, and independence.
Experts strongly recommend adopting pacing strategies to manage energy and avoid setbacks. This involves planning activities in advance, taking regular rest breaks, and recognizing early signs of fatigue to prevent overexertion. Keeping an activity log can help identify triggers and patterns. For those with severe symptoms, working with occupational therapists or rehabilitation specialists can provide tailored support. Addressing chronic fatigue early is critical for preserving function and improving long-term quality of life.

26. Involuntary Muscle Twitches

26. Involuntary Muscle Twitches
A close-up view of a hand experiencing a muscle twitch, highlighting the intricate connection to the nervous system in neurology. | Generated by Google Gemini

A lesser-known but increasingly reported symptom among Long COVID patients is the appearance of involuntary muscle twitches, or fasciculations. These sudden, brief contractions can affect any muscle group and are often caused by nerve hyperexcitability—where nerves fire off signals abnormally due to lingering inflammation or immune dysfunction. This pattern is reminiscent of benign fasciculation syndrome, a condition where twitches occur without underlying disease.
Most muscle twitches are harmless and may come and go, but for some, they can be persistent and distracting, particularly when accompanied by cramps or muscle fatigue. Anxiety and stress, which are common in the context of chronic illness, can further amplify these sensations.
While benign in most cases, it’s important to rule out neurological disease if twitches are accompanied by muscle weakness, atrophy, numbness, or changes in reflexes. Consulting a neurologist for evaluation and possible nerve conduction studies can provide reassurance and help identify rare but serious conditions such as motor neuron disease. Early assessment is especially warranted if symptoms worsen or interfere with daily activities.

27. Autonomic Dysfunction

27. Autonomic Dysfunction
A detailed diagram illustrates the autonomic nervous system, highlighting disruptions seen in dysautonomia and POTS conditions. | Generated by Google Gemini

One of the more complex and disruptive symptoms seen in Long COVID is autonomic dysfunction, also known as dysautonomia. This condition occurs when the autonomic nervous system—which controls automatic body functions like heart rate, blood pressure, and digestion—becomes impaired. Many patients develop symptoms similar to postural orthostatic tachycardia syndrome (POTS), a disorder in which the heart rate increases abnormally upon standing NIH.
Common signs of dysautonomia include dizziness, lightheadedness, and fainting spells, especially when moving from sitting to standing. Additional symptoms can include heart palpitations, excessive fatigue, brain fog, temperature intolerance, and digestive disturbances. These issues can fluctuate in severity and may be triggered by heat, exertion, or even emotional stress.
If you experience persistent or worsening symptoms of autonomic dysfunction, it is important to consult a healthcare provider—preferably a neurologist or cardiologist experienced with POTS and related disorders. Diagnosis often involves tilt-table testing and heart rate monitoring. Treatment may include increased salt and fluid intake, medications, and physical therapy to help stabilize blood pressure and heart rate, improving daily function and quality of life.

28. New-Onset Hypertension

28. New-Onset Hypertension
A healthcare professional carefully checks a patient’s blood pressure, highlighting the importance of vascular health in managing hypertension. | Generated by Google Gemini

An unexpected and increasingly recognized consequence of Long COVID is new-onset hypertension—the development of high blood pressure in individuals with no prior history. Researchers suspect that prolonged vascular inflammation, triggered by the body’s immune response to the virus, may damage the lining of blood vessels and alter their ability to regulate pressure. This process is similar to secondary hypertension, where an underlying condition results in elevated blood pressure rather than a primary genetic or lifestyle cause American Heart Association.
Patients may not initially notice symptoms, as hypertension is often asymptomatic, but some report new headaches, visual changes, or a sense of pressure in the chest or head. Over time, uncontrolled high blood pressure can increase the risk of heart attack, stroke, and kidney disease.
Healthcare providers recommend regular blood pressure monitoring for all Long COVID patients, particularly if they have risk factors such as age, obesity, or family history. Home blood pressure cuffs can help track trends between office visits. If new-onset hypertension is detected, early intervention with lifestyle changes or medication can significantly reduce long-term cardiovascular risks.

29. Swollen Lymph Nodes

29. Swollen Lymph Nodes
Swollen lymph nodes highlighted beneath the skin illustrate the immune system’s response to infection or inflammation. | Generated by Google Gemini

A notable symptom for some individuals with Long COVID is the presence of swollen lymph nodes—a sign of chronic immune activation. The body’s lymphatic system may remain on high alert, as if still fighting the virus, leading to persistent swelling in the neck, armpits, or groin. This prolonged immune response is reminiscent of glandular fever (infectious mononucleosis), where lymph nodes can stay enlarged for weeks or months due to ongoing viral or immune activity NIH.
Most swollen lymph nodes in Long COVID are painless and rubbery, but they can occasionally be tender or accompanied by low-grade fever and fatigue. While this reaction is usually benign, persistent or rapidly enlarging lymph nodes warrant further evaluation.
Healthcare providers advise investigating persistent lymphadenopathy (enlarged lymph nodes lasting more than four weeks), especially if nodes are hard, fixed, associated with night sweats, weight loss, or unexplained fever. Additional tests such as blood work, imaging, or biopsy may be necessary to rule out other causes, including secondary infections or, rarely, malignancy. Prompt assessment ensures appropriate management and peace of mind.

30. Loss of Coordination

30. Loss of Coordination
A neurologist guides a patient through balance exercises, highlighting the intricate link between coordination and brain function. | Generated by Google Gemini

Some Long COVID patients experience a loss of coordination, which can affect balance, walking, and fine motor skills. This troubling symptom may be due to impairment of the cerebellum—the part of the brain responsible for controlling movement—or from damage to peripheral nerves. The clinical presentation often resembles ataxia, a neurological condition where coordination and voluntary muscle movements become erratic or clumsy.
Daily activities such as writing, buttoning clothes, or even standing steadily may become increasingly difficult. Some individuals report frequent stumbling, unsteady gait, or dropping objects. These issues can lead to falls, injuries, and a significant reduction in independence and confidence.
Experts stress the importance of early neurological assessment if you experience new or worsening loss of coordination after COVID-19. A comprehensive evaluation by a neurologist, including imaging and nerve conduction studies, can help identify the underlying cause and guide treatment. Physical and occupational therapy may also play a critical role in improving mobility and function. Early intervention increases the likelihood of recovery and can help prevent further complications related to balance and movement.

31. New Food Intolerances

31. New Food Intolerances
A colorful assortment of fresh fruits, vegetables, and gluten-free grains highlights a gut-friendly diet for food intolerance. | Generated by Google Gemini

Emerging evidence suggests that some Long COVID patients develop new food intolerances that didn’t exist before their infection. Scientists believe this may be linked to disruptions in the gut microbiome— the diverse community of bacteria and other microbes that support digestion and immune function. When the balance of the microbiome is disturbed, the body can become less capable of properly digesting certain foods, leading to symptoms like bloating, cramps, diarrhea, or nausea. This is similar to how some people develop lactose intolerance after gastrointestinal infections.
Common triggers include dairy, gluten, high-fiber foods, or artificial sweeteners. These changes can be frustrating and confusing, especially for those who previously enjoyed a diverse diet without issue. Persistent food intolerances can also impact nutrition and overall well-being.
Dietitians recommend tracking symptoms and food intake in a journal to help identify patterns and potential triggers. Working with a registered dietitian can ensure nutritional needs are met while avoiding problematic foods. Reintroduction protocols may help restore tolerance over time. If gastrointestinal symptoms are severe or accompanied by weight loss or blood in the stool, prompt medical evaluation is essential.

32. Menstrual Irregularities

32. Menstrual Irregularities
A colorful diagram illustrates the phases of the menstrual cycle, highlighting key hormones and their roles in gynecology. | Generated by Google Gemini

A growing body of evidence indicates that Long COVID can cause menstrual irregularities in individuals who previously had regular cycles. These changes may manifest as missed periods, heavier or lighter bleeding, or unpredictable timing. Researchers suspect that the stress of illness and chronic inflammation can disrupt the hypothalamic-pituitary-ovarian axis, leading to hormonal imbalances. This effect is similar to stress-induced amenorrhea, where psychological or physical stress temporarily halts or alters menstrual cycles.
Some may also experience changes in premenstrual symptoms, increased cramps, or spotting between periods. For those with pre-existing conditions like polycystic ovary syndrome (PCOS), Long COVID may exacerbate symptoms or make cycles more unpredictable.
Gynecologists recommend tracking your cycles using a calendar or mobile app to help identify patterns or abnormalities. If cycles remain irregular for several months, are associated with severe pain, or are accompanied by other symptoms such as unexplained weight loss or abnormal hair growth, consult a gynecologist. Early evaluation can rule out other causes, provide reassurance, and guide appropriate treatment or hormonal support to restore regularity and well-being.

33. Severe Acid Reflux

33. Severe Acid Reflux
A detailed illustration of the digestive system highlights acid reflux, showing stomach acid backing up into the esophagus, causing GERD symptoms. | Generated by Google Gemini

A growing number of Long COVID patients report experiencing severe acid reflux or heartburn, often for the first time. This may be due to dysfunction of the vagus nerve, which helps control the muscles of the digestive tract—including the esophagus. When the vagus nerve is inflamed or damaged, the normal movement of food down the esophagus can be disrupted, allowing stomach acid to flow backward and cause irritation. This condition is similar to gastroesophageal reflux disease (GERD), but may be more persistent or severe after COVID-19.
Symptoms can include burning chest pain, regurgitation, chronic cough, sore throat, or difficulty swallowing. Some patients also notice worsening symptoms at night or after large meals. Persistent acid reflux can erode the lining of the esophagus, leading to complications if left untreated.
If you experience refractory or severe acid reflux that does not improve with over-the-counter remedies, it’s important to escalate care to a gastroenterologist. Early intervention may involve prescription medications, dietary changes, or further evaluation to rule out damage to the esophagus. Addressing symptoms early can prevent long-term complications and improve quality of life.

34. New-Onset Asthma

34. New-Onset Asthma
A pair of healthy lungs is illustrated beside an asthma inhaler, highlighting the importance of respiratory care. | Generated by Google Gemini

A surprising respiratory complication increasingly reported in Long COVID is new-onset asthma. This condition typically arises from airway hyperreactivity that develops after viral infection. The immune system, still in a heightened state, causes the bronchial tubes to become inflamed and overly sensitive, similar to what is seen in children who develop asthma following respiratory viruses NIH.
Symptoms include recurrent wheezing, coughing, chest tightness, and shortness of breath, particularly with exercise or at night. These symptoms may be intermittent or persistent, and can significantly affect daily activities and sleep quality. Triggers such as cold air, allergens, or stress may worsen the condition.
Treatment often involves the use of inhalers to manage inflammation and acute symptoms. Common options include short-acting bronchodilators (rescue inhalers), inhaled corticosteroids for long-term control, or combination inhalers that address both inflammation and airway constriction. If you experience new or persistent asthma-like symptoms after COVID-19, consult a healthcare provider for diagnosis and personalized management. Early intervention can improve lung function, reduce flare-ups, and help prevent long-term respiratory complications.

35. Delayed Allergic Reactions

35. Delayed Allergic Reactions
A close-up of irritated skin shows a red, blotchy rash, highlighting the immune system’s response to an allergic reaction. | Generated by Google Gemini

Long COVID can disrupt the immune system’s ability to distinguish between harmless and harmful substances, leading to delayed allergic reactions that may appear hours or even days after exposure. This altered immune tolerance can cause the body to react to medications, foods, or environmental triggers in ways not previously experienced. The phenomenon is somewhat similar to serum sickness, an immune complex-mediated reaction that occurs in response to certain drugs or antitoxins, often with delayed onset.
Symptoms might include rash, swelling, joint pain, fever, or digestive upset, and can be especially confusing since they don’t always follow immediate exposure. Some patients may also develop delayed-onset hives or breathing difficulties, which can escalate without prompt intervention.
Scenarios that require urgent allergy care include any signs of anaphylaxis—such as throat swelling, difficulty breathing, rapid heartbeat, or sudden drop in blood pressure—or persistent, unexplained rashes or swelling. If delayed allergic reactions are suspected, an allergist can perform specialized testing and advise on avoidance strategies or emergency medications like epinephrine auto-injectors. Prompt medical attention is crucial for severe or rapidly progressing symptoms.

36. Painful Swelling in Extremities

36. Painful Swelling in Extremities
Hands and feet appear visibly swollen, highlighting pronounced veins and vascular changes associated with fluid retention. | Generated by Google Gemini

Some Long COVID sufferers experience painful swelling in the hands, feet, or other extremities, which can last for weeks or months. This symptom is often linked to vascular inflammation and the formation of microclots—tiny blood clots that obstruct small vessels and disrupt normal blood flow. The resulting redness, tenderness, and swelling resemble chilblains (also known as “COVID toes”), a condition where the skin reacts to inflammation and poor circulation after viral infection NIH.
Affected areas may feel hot, look purplish or mottled, and, in severe cases, the skin may crack or blister. These symptoms can be aggravated by exposure to cold, prolonged immobility, or minor trauma. In rare cases, the swelling and pain can signal more serious vascular complications, such as deep vein thrombosis.
It’s important to monitor for signs of poor circulation: persistent coldness, numbness, bluish skin, or severe pain in the extremities. If these symptoms arise or if swelling is accompanied by shortness of breath or chest pain, seek immediate medical attention. Early evaluation can prevent complications and guide targeted therapies for vascular health.

37. Loss of Libido

37. Loss of Libido
A couple sits close together, smiling and holding hands, surrounded by symbols of hormones and vibrant sexual health. | Generated by Google Gemini

A frequently overlooked but impactful symptom of Long COVID is the loss of libido, or reduced interest in sexual activity. This can be driven by a mix of hormonal imbalances—such as lowered testosterone or estrogen—and psychological changes like anxiety, depression, and fatigue. The phenomenon is not unique to COVID-19; other infections have also been shown to disrupt sexual function during recovery, a pattern recognized as post-infectious sexual dysfunction.
People may notice less desire, difficulty with arousal, or decreased satisfaction, sometimes compounded by physical symptoms like pain, fatigue, or sleep disturbances. The emotional stress of chronic illness and the uncertainty of recovery can further dampen sexual interest and strain relationships.
Healthcare providers encourage open communication about these issues, both with partners and medical professionals. Sexual health is an important aspect of overall well-being, and addressing it can help improve mood, intimacy, and self-esteem. Providers can offer hormonal assessments, counseling, or referrals to specialists if needed. Early discussion prevents unnecessary distress and helps tailor supportive therapies for full Long COVID recovery.

38. New-Onset Migraines

38. New-Onset Migraines
A woman sits in a quiet room, holding her head in pain as a neurologist reviews migraine scan results nearby. | Generated by Google Gemini

A significant number of Long COVID patients report developing new-onset migraines—intense, throbbing headaches often accompanied by sensitivity to light, sound, and sometimes nausea. Researchers believe this is due to neurovascular changes and persistent inflammation in the brain and blood vessels following COVID-19 infection. The pattern is similar to post-traumatic headaches, where injury or stress to the nervous system leads to chronic migraine-like symptoms.
Migraines after COVID-19 may be more frequent, severe, or resistant to usual treatments compared to pre-existing headaches. Some individuals experience aura—visual or sensory disturbances—before the pain begins. These headaches can disrupt work, family life, and sleep, further compounding post-COVID fatigue and cognitive difficulties.
Neurologists recommend keeping a headache diary to track triggers, patterns, and response to medications or lifestyle changes. This tool helps both patients and providers identify effective treatments and avoid potential triggers. If migraines are new, worsening, or associated with neurological changes such as weakness, vision loss, or confusion, seek prompt medical evaluation to rule out other causes and optimize headache management.

39. Chronic Sinus Congestion

39. Chronic Sinus Congestion
A close-up of an ENT doctor examining a patient’s nasal passages, illustrating the discomfort of sinus congestion. | Generated by Google Gemini

Many Long COVID patients struggle with chronic sinus congestion that persists long after their initial infection. This ongoing stuffiness and pressure is believed to stem from persistent inflammation of the upper airways and sinus linings, which can linger for months. The experience is very similar to chronic sinusitis, where swelling, mucus production, and blocked passages interfere with normal breathing and smell.
Common symptoms include nasal obstruction, postnasal drip, facial pain or pressure, and reduced sense of smell. These issues can disrupt sleep, lead to headaches, and make daily life uncomfortable. In some cases, congestion is accompanied by recurring sinus infections or ear pressure.
Experts advise seeking ENT (ear, nose, and throat) care if sinus congestion is severe, persistent for more than three months, or associated with fever, thick discolored nasal discharge, or vision changes. An ENT specialist can provide targeted treatments, such as nasal corticosteroids, saline rinses, or in rare cases, minor procedures to relieve obstruction. Early intervention can ease symptoms, prevent complications, and support better quality of life during Long COVID recovery.

40. New-Onset High Cholesterol

40. New-Onset High Cholesterol
A detailed lipid panel report lies beside a stethoscope, highlighting cholesterol levels and markers of metabolic health. | Generated by Google Gemini

Emerging research suggests that some Long COVID patients develop new-onset high cholesterol even without previous risk factors. This is thought to be due to metabolic disruption caused by the virus and the body’s prolonged inflammatory response, which can alter how fats are processed and transported in the bloodstream. Several studies have documented increases in total cholesterol, LDL (“bad” cholesterol), and triglycerides in those recovering from COVID-19 NIH.
These lipid abnormalities may go unnoticed at first, as high cholesterol rarely causes symptoms. However, if left untreated, they significantly increase the risk of heart disease, stroke, and other vascular complications. Some patients may also notice other metabolic changes, such as weight gain or changes in blood sugar.
Healthcare providers underscore the importance of regular lipid panel testing for anyone recovering from COVID-19, especially if there are additional risk factors like age, obesity, or a family history of heart disease. Early detection allows for timely lifestyle interventions or medications to help manage cholesterol levels and protect long-term cardiovascular health. If high cholesterol is found, discuss a tailored plan with your provider.

41. Unusual Bruising

41. Unusual Bruising
A close-up view of bruised skin reveals underlying blood cells, highlighting the complexities studied in hematology. | Generated by Google Gemini

A less common but concerning symptom reported by some Long COVID patients is unusual bruising—the appearance of dark purple or blue marks on the skin with minimal or no trauma. This can be a sign of platelet abnormalities, where the cells responsible for blood clotting are either reduced or not functioning properly. Such changes may occur due to ongoing inflammation, autoimmune activity, or direct effects of the virus on the bone marrow and vascular system. The phenomenon is similar to what is seen in blood clotting disorders, such as immune thrombocytopenia or even certain forms of vasculitis NIH.
Patients may also notice tiny red or purple spots (petechiae) or larger patches (purpura) that do not fade under pressure. While some bruising is harmless, a sudden increase or easy bruising without explanation warrants further investigation.
Healthcare providers highlight the importance of checking blood counts and clotting factors if unexplained bruising arises, especially if accompanied by other symptoms like bleeding gums, nosebleeds, or fatigue. Early blood testing can help identify underlying issues and guide appropriate treatment to prevent more severe complications.

42. Persistent Hiccups

42. Persistent Hiccups
A diagram illustrates how irritation of the phrenic nerve can cause hiccups, highlighting it as a common symptom. | Generated by Google Gemini

A surprising and often frustrating symptom experienced by some Long COVID patients is persistent hiccups. This can occur when the phrenic nerve—which controls the diaphragm—becomes irritated or inflamed during or after infection. Persistent hiccups have also been reported with other viral illnesses, where nerve inflammation leads to repeated, involuntary contractions of the diaphragm lasting hours or even days NIH.
While occasional hiccups are harmless, persistent or intractable hiccups can cause discomfort, disrupt sleep, and lead to fatigue or social embarrassment. They may be accompanied by chest discomfort or abdominal pain, especially after eating or drinking.
For symptom relief, try classic remedies such as sipping cold water, holding your breath, or swallowing a teaspoon of sugar. Gentle pressure on the diaphragm or breathing into a paper bag may also help interrupt the hiccup reflex. If hiccups last longer than 48 hours, or are associated with other symptoms like vomiting, weight loss, or chest pain, consult a healthcare provider. Persistent hiccups may indicate underlying nerve or organ irritation that requires further evaluation and treatment.

43. New-Onset Autoimmune Disorders

43. New-Onset Autoimmune Disorders
A detailed diagram illustrates the immune system’s cells attacking joint tissue, highlighting the complexities of autoimmune diseases in rheumatology. | Generated by Google Gemini

Long COVID has been associated with a rise in new-onset autoimmune disorders among individuals who previously had no autoimmune history. Researchers believe that immune dysregulation—where the body’s immune system fails to turn off after infection—can trigger the development of diseases such as lupus, rheumatoid arthritis, or autoimmune thyroiditis. Recent journal reports highlight a growing number of cases in which patients develop symptoms of autoimmune disease weeks or months after recovering from COVID-19 JAMA.
Autoimmune disorders can present with a wide range of symptoms, including joint pain, persistent rashes, fatigue, fevers, and organ inflammation. The unpredictable and sometimes severe nature of these diseases can be physically and emotionally overwhelming.
Experts recommend early referral to a specialist—such as a rheumatologist or endocrinologist—if new autoimmune symptoms develop after COVID-19. Prompt evaluation can lead to early diagnosis and targeted treatment, which is crucial for preventing long-term organ damage and improving quality of life. Ongoing research aims to clarify why Long COVID may trigger autoimmunity and how best to support affected patients.

44. Loss of Bladder Control

44. Loss of Bladder Control
A neurologist explains bladder control to a patient using an anatomical model and diagrams illustrating urinary incontinence. | Generated by Google Gemini

A troubling but under-recognized symptom in some Long COVID patients is loss of bladder control, which may manifest as urgency, frequency, or incontinence. This can result from both neurological and muscular impacts of the virus. When nerves that control the bladder are inflamed or damaged, the signals necessary for coordinated urination can be disrupted. This presentation is reminiscent of symptoms seen in multiple sclerosis (MS), where similar nerve damage leads to bladder dysfunction.
Some individuals may also experience difficulty fully emptying the bladder, weak urine stream, or increased nighttime urination. These issues can be embarrassing, disrupt sleep, and significantly reduce quality of life.
Experts advise seeking urology or neurology input if you notice new bladder control problems after COVID-19, especially if symptoms are severe, persistent, or accompanied by numbness, tingling, or weakness in the legs. Early assessment can help distinguish between infection, nerve-related causes, or other underlying conditions. Urologists and neurologists may recommend pelvic floor exercises, medications, or further diagnostic testing to guide effective treatment and restore bladder function.

45. Severe Abdominal Pain

45. Severe Abdominal Pain
A person gently clutches their stomach, highlighting the discomfort often associated with abdominal pain and digestive issues. | Generated by Google Gemini

Some individuals with Long COVID develop severe abdominal pain that can be both persistent and unpredictable. This discomfort is often tied to ongoing gastrointestinal inflammation, where the lining of the stomach or intestines remains irritated long after the initial infection has resolved. In some cases, the symptoms parallel those of irritable bowel syndrome (IBS), which is also known to follow viral illnesses and is marked by cramping, bloating, and changes in bowel habits.
Abdominal pain may be sharp or cramping, localize to one area, or move around the abdomen. It can be accompanied by nausea, diarrhea, constipation, or loss of appetite. For some, these symptoms disrupt daily activities and can cause significant anxiety.
It is crucial to watch for red flags that require emergency care: severe or sudden-onset pain, pain with vomiting blood, black or tarry stools, persistent fever, or signs of dehydration. If these symptoms arise, seek immediate medical attention, as they may indicate a more serious underlying problem such as bowel obstruction, infection, or organ damage. Early evaluation and intervention are key to preventing complications and ensuring recovery.

46. Persistent Dry Mouth

46. Persistent Dry Mouth
A detailed illustration of the salivary glands highlights their vital role in preventing dry mouth and supporting oral health. | Generated by Google Gemini

An often-overlooked symptom in Long COVID is persistent dry mouth, also known as xerostomia. This condition may result from inflammation or dysfunction of the salivary glands, which can occur as part of the body’s prolonged immune response. The presentation is strikingly similar to Sjögren’s syndrome, an autoimmune disease where the immune system attacks moisture-producing glands, leading to chronic dryness of the mouth and eyes.
Symptoms include a sticky or burning sensation in the mouth, difficulty swallowing dry foods, frequent thirst, and changes in taste. Dry mouth can increase the risk of cavities, oral infections, and gum disease, compounding the discomfort and inconvenience for those affected.
Dentists recommend several dental hygiene tips to manage and prevent complications: sip water frequently, use sugar-free lozenges or gum to stimulate saliva, avoid caffeine and alcohol, and maintain regular brushing and flossing. If dry mouth persists, a dental or medical evaluation is important to rule out other causes and discuss saliva substitutes or prescription therapies. Prioritizing oral health is essential for comfort and to prevent long-term dental problems during Long COVID recovery.

47. New-Onset Depression

47. New-Onset Depression
A solitary figure sits by a rain-streaked window, soft light casting shadows that reflect a somber mood. | Generated by Google Gemini

A growing concern in the aftermath of COVID-19 is new-onset depression among individuals with no prior mental health history. This can be attributed to both neurochemical imbalances—where inflammation and immune changes disrupt neurotransmitters like serotonin and dopamine—and the significant psychosocial stressors that come with prolonged illness. Lost work, strained relationships, and persistent health uncertainty all contribute to a heightened risk of depressive symptoms. Recent mental health surveys have shown a marked increase in depression rates among COVID-19 survivors KFF.
Common signs include persistent sadness, hopelessness, loss of interest in previously enjoyable activities, changes in appetite or sleep, fatigue, and difficulty concentrating. These symptoms can be severe and have a profound impact on daily life and recovery.
Experts recommend screening for mood disorders in all Long COVID patients, especially if depressive symptoms persist for more than two weeks. Early identification allows for timely intervention with therapy, medication, or support groups. Addressing depression is crucial—not just for mental health, but for optimizing physical recovery and overall well-being.

48. Delayed Wound Healing

48. Delayed Wound Healing
A close-up view of skin in the process of wound healing, highlighting immune cells working to repair damaged tissue. | Generated by Google Gemini

A lesser-known complication of Long COVID is delayed wound healing, where cuts, scrapes, or surgical incisions take longer than usual to close and repair. This issue is thought to arise from an impaired immune response paired with reduced vascular supply to affected tissues. The immune system’s lingering dysregulation can limit the delivery of vital nutrients and immune cells needed for efficient tissue regeneration. This phenomenon is similar to the slow wound healing seen in people with diabetes, where high blood sugar impairs circulation and immune function NIH.
Patients may notice wounds that remain red, swollen, or fail to form scabs, and an increased risk of infection or persistent drainage. Such wounds are more likely to leave scars or require medical intervention.
Healthcare providers stress the importance of wound care consultation if you observe slow-healing wounds after COVID-19. Specialized wound care teams can offer advanced dressings, infection control, and strategies to enhance healing. Early intervention is critical to prevent complications, reduce pain, and ensure proper recovery—especially in those with underlying health concerns or chronic conditions.

49. New-Onset Epilepsy

49. New-Onset Epilepsy
A detailed illustration of the human brain highlights abnormal electrical activity, visually representing a seizure caused by epilepsy. | Generated by Google Gemini

A rare but serious complication emerging in Long COVID patients is new-onset epilepsy. Researchers suspect that chronic brain changes—such as persistent neuroinflammation, scar tissue formation, or altered electrical activity—may increase the risk of recurrent seizures in some individuals. This is reminiscent of epilepsy that can develop after a traumatic brain injury, where ongoing disruption of brain networks creates a lower threshold for seizure activity NIH.
Symptoms of new-onset epilepsy may include sudden and unexplained episodes of confusion, staring spells, involuntary movements, or convulsions. Some patients may experience aura symptoms, such as strange smells or visual disturbances, before a seizure.
Neurologists recommend that anyone experiencing recurrent or severe neurological symptoms after COVID-19 seek prompt evaluation for possible epilepsy. Seizure precautions are vital: avoid swimming or bathing alone, operate vehicles only if cleared by your doctor, and educate close contacts about seizure first aid. Timely diagnosis with EEG and brain imaging can support effective management with medication and reduce the risk of injury. Early intervention is key to maintaining safety and quality of life.

50. Increased Sensitivity to Medications

50. Increased Sensitivity to Medications
A pharmacist consults with a patient while displaying medication bottles, highlighting concerns about sensitivity and immune response. | Generated by Google Gemini

A puzzling but increasingly recognized symptom in Long COVID is increased sensitivity to medications. Patients may experience stronger or more unusual side effects from drugs they previously tolerated well. This phenomenon is thought to stem from altered metabolism—where liver enzymes and kidney function are disrupted by lingering inflammation—and from heightened immune responses, which can trigger medication hypersensitivity. Similar patterns are seen in other chronic illnesses, such as lupus and chronic fatigue syndrome, where immune and metabolic changes affect drug processing and tolerance NIH.
Reactions may include nausea, dizziness, rashes, or even severe allergic responses after taking common medications like antibiotics, pain relievers, or antidepressants. For some, the therapeutic dose may need to be reduced, or alternative drugs may be required.
Experts strongly recommend reviewing all medications with a healthcare provider if you are recovering from COVID-19 and notice new or exaggerated side effects. Keep an up-to-date list of all drugs, including over-the-counter and supplements, and discuss any changes in reactions or symptoms. Careful medication management ensures safety and optimizes treatment effectiveness during Long COVID recovery.

Conclusion

Conclusion
A caring doctor discusses health screening results with a patient, fostering trust during a thorough medical consultation. | Generated by Google Gemini

The sheer breadth of emerging Long COVID symptoms underscores the urgency of recognizing this condition as a complex, multi-system challenge. From neurological complications to immune, respiratory, and vascular issues, Long COVID can affect nearly every organ. Early screening and multidisciplinary care are crucial for improving outcomes and quality of life.
Practical steps—such as keeping a detailed symptom diary, staying proactive with regular health checks, and consulting healthcare professionals for any persistent or worsening symptoms—can help ensure timely intervention. If you or a loved one are experiencing ongoing health changes after COVID-19, don’t hesitate to seek support and specialist input. The road to recovery may be long, but early action is vital for the best possible results.

Disclaimer

The information provided in this article is for general informational purposes only. While we strive to keep the information up-to-date and correct, we make no representations or warranties of any kind, express or implied, about the completeness, accuracy, reliability, suitability, or availability with respect to the article or the information, products, services, or related graphics contained in the article for any purpose. Any reliance you place on such information is therefore strictly at your own risk.

In no event will we be liable for any loss or damage including without limitation, indirect or consequential loss or damage, or any loss or damage whatsoever arising from loss of data or profits arising out of, or in connection with, the use of this article.

Through this article you are able to link to other websites which are not under our control. We have no control over the nature, content, and availability of those sites. The inclusion of any links does not necessarily imply a recommendation or endorse the views expressed within them.

Every effort is made to keep the article up and running smoothly. However, we take no responsibility for, and will not be liable for, the article being temporarily unavailable due to technical issues beyond our control.

Advertisement