The Silent Sign of Stomach Cancer Hiding in Your Belly

1. Persistent Indigestion

While occasional indigestion is common and often linked to dietary choices or stress, chronic or persistent indigestion can sometimes be an early warning sign of stomach cancer. Normal indigestion, also known as dyspepsia, usually causes temporary discomfort such as bloating, mild nausea, or heartburn after eating spicy or fatty foods. However, when indigestion occurs frequently, lasts for several weeks, or is unrelieved by over-the-counter medications, it may be cause for concern.

Persistent indigestion related to stomach cancer can present as a gnawing or burning sensation in the upper abdomen, a feeling of fullness after eating small amounts, or ongoing mild nausea. Unlike common indigestion, these symptoms don’t resolve with typical remedies and may gradually worsen over time. It is important to distinguish between harmless, short-lived digestive discomfort and ongoing symptoms that could indicate a more serious problem.

If you experience indigestion that doesn’t improve, is accompanied by unexplained weight loss, vomiting, or difficulty swallowing, you should consult a healthcare professional promptly. Early detection can dramatically improve outcomes. For more information on when to seek care, visit the American Cancer Society’s guide on stomach cancer symptoms.

2. Unexplained Weight Loss

Unintentional or unexplained weight loss is a significant warning sign that may indicate the presence of stomach cancer. Unlike weight loss achieved through intentional dieting or exercise, this type of weight loss occurs without any lifestyle changes and can be rapid or gradual. In stomach cancer, weight loss is often the result of several factors: the tumor may interfere with the stomach’s ability to digest and absorb nutrients, or it might release substances that alter metabolism and suppress appetite.

As the cancer progresses, people might feel full after eating only small amounts, experience nausea, or lose their appetite entirely. These factors combined can lead to a noticeable drop in body weight over weeks or months. In contrast, intentional weight loss is usually gradual, planned, and accompanied by increased physical activity or dietary adjustments.

While minor fluctuations in weight are normal, losing more than 5% of your body weight without trying within six to twelve months should prompt a visit to your healthcare provider. This is especially important if weight loss is accompanied by other stomach cancer symptoms. For more details, refer to the Cancer.Net stomach cancer symptoms guide.

3. Early Satiety

Early satiety describes the sensation of feeling full after eating only a small amount of food, often far less than what you would normally consume in a meal. This symptom can be particularly alarming when it develops suddenly or persists over time. In the context of stomach cancer, a growing tumor can physically occupy space within the stomach, reducing its capacity to hold food and making it difficult for the stomach to expand as it normally would during eating.

As a result, individuals may find themselves unable to finish even modest portions, leading to reduced calorie intake and unintended weight loss. Early satiety might also be accompanied by bloating, mild pain, or discomfort in the upper abdomen. While mild or occasional early satiety can sometimes be caused by benign conditions such as indigestion, peptic ulcers, or anxiety, persistent early satiety should not be ignored, especially if it is new or worsening.

If you experience ongoing early satiety, particularly in combination with other symptoms such as weight loss, nausea, or persistent indigestion, it is important to seek medical evaluation. For more about this symptom and its link to stomach cancer, visit the American Cancer Society’s stomach cancer signs and symptoms page.

4. Abdominal Discomfort or Pain

Abdominal discomfort or pain is a symptom that can be linked to many common conditions, but when persistent or unexplained, it may signal a more serious issue such as stomach cancer. The pain associated with stomach cancer is typically described as a dull ache or a sense of pressure in the upper abdomen. This discomfort may start mildly and gradually intensify as the tumor grows or invades surrounding tissues. In some cases, it may radiate to the back or be mistaken for indigestion or heartburn.

Unlike typical stomachaches, which are usually short-lived and related to dietary choices, infections, or stress, cancer-related abdominal pain tends to persist over time and does not improve with over-the-counter remedies. It may also be accompanied by other warning signs such as persistent nausea, early satiety, or unexplained weight loss. Monitoring the duration, frequency, and intensity of your abdominal discomfort is crucial in identifying when the symptom may be more than just a minor digestive issue.

If you experience ongoing or worsening abdominal discomfort, especially when combined with other gastrointestinal symptoms, it is important to consult a healthcare provider for a thorough evaluation. For more details, see the Cancer Research UK guide to stomach cancer symptoms.

5. Nausea and Vomiting

Nausea is a subtle yet important symptom that can occur with stomach cancer, often overlooked or mistaken for less serious conditions. While nearly everyone experiences mild nausea from time to time—due to viral infections, food poisoning, or even anxiety—persistent or unexplained nausea can be a warning sign of an underlying problem. In the case of stomach cancer, tumors may block the normal movement of food, irritate the stomach lining, or disrupt digestive processes, leading to ongoing or worsening nausea.

Vomiting, especially if it becomes frequent or severe, is another red flag. Occasional vomiting is usually related to benign causes, but recurring episodes—particularly when not linked to dietary indiscretion, illness, or motion sickness—require attention. Vomiting that contains blood or looks like coffee grounds is especially concerning, as it may indicate bleeding within the stomach. This is a serious symptom that warrants immediate medical evaluation.

If you experience persistent nausea or vomiting, especially when accompanied by other symptoms such as weight loss, early satiety, or abdominal pain, it is important to speak with your healthcare provider. For more information, refer to the NHS stomach cancer symptoms guide.

6. Blood in Stool

Blood in the stool can be a subtle but serious symptom of stomach cancer, often resulting from bleeding within the gastrointestinal tract. As a tumor grows, it can erode the stomach lining or nearby blood vessels, leading to slow, chronic bleeding. This may not always appear as obvious red blood in the stool; more often, it presents as black, tarry stools (melena), which indicate digested blood passing through the digestive system.

However, blood in stool can also be caused by less serious conditions such as hemorrhoids, anal fissures, or minor gastrointestinal infections. Even so, any unexplained or persistent presence of blood—especially when accompanied by other symptoms like abdominal discomfort, fatigue, or unexplained weight loss—should not be ignored. Gastrointestinal bleeding from stomach cancer may also lead to anemia, resulting in persistent tiredness or weakness.

It is important to consult a doctor promptly if you notice blood in your stool, whether it is bright red or dark and tarry. Early evaluation can help identify the cause and initiate appropriate treatment. For more detailed information, visit the Mayo Clinic’s stomach cancer page.

7. Anemia

Anemia is a condition characterized by a deficiency of healthy red blood cells or hemoglobin, which impairs the body’s ability to carry oxygen to tissues. In stomach cancer, slow internal bleeding from the tumor can gradually deplete the body’s iron stores, leading to iron-deficiency anemia. Unlike ordinary tiredness from a busy lifestyle, anemia caused by chronic blood loss is persistent and often intensifies over time. Symptoms may include ongoing fatigue, weakness, pale or sallow skin, shortness of breath, and dizziness.

While general fatigue is a common complaint and can result from lack of sleep, stress, or overexertion, anemia due to stomach cancer is often more severe and not relieved by rest. Individuals may notice that even mild physical activity leaves them feeling unusually exhausted. In some cases, there may be visible signs, such as brittle nails or cold hands and feet, which are less typical of regular fatigue.

If you are experiencing persistent tiredness or other symptoms of anemia, it is important to seek medical advice. A simple blood test can determine if anemia is present and whether further investigation is warranted. For more on anemia and stomach cancer, see the American Cancer Society’s stomach cancer symptoms page.

8. Feeling Bloated After Meals

Feeling bloated after meals is a common digestive complaint, but when it occurs persistently, it may signal an underlying issue such as stomach cancer. Tumors in the stomach can partially obstruct the passage of food, slowing digestion and causing a sensation of fullness, tightness, or swelling in the upper abdomen. This type of bloating is often more pronounced immediately after eating, even if only a small meal is consumed, and does not resolve with typical remedies.

In contrast, bloating from dietary choices—such as eating foods high in fiber, carbonated drinks, or beans—tends to be temporary and usually improves with lifestyle adjustments. Occasional bloating from overeating or sensitivity to certain foods is generally harmless. However, when bloating is persistent, new, or accompanied by other warning signs like early satiety, unintentional weight loss, or abdominal pain, it may warrant further investigation.

It is important to pay attention to bloating that seems unusual for you or does not go away after changing your diet. If you notice ongoing bloating, especially alongside other gastrointestinal symptoms, consult a healthcare provider for assessment. For more details, visit the American Cancer Society’s stomach cancer symptoms guide.

9. Loss of Appetite

Loss of appetite, or a reduced desire to eat, can be an early and often overlooked symptom of stomach cancer. Tumors in the stomach may disrupt normal digestive processes, cause inflammation, or produce substances that alter hunger signals, all of which can contribute to a persistent lack of appetite. This symptom is particularly concerning when it develops suddenly, is ongoing, and is not related to obvious causes such as a viral illness or emotional stress.

It is common for appetite to fluctuate with stress, anxiety, or temporary circumstances such as grief or intense work periods. In these cases, appetite typically returns as the situation resolves. However, when appetite loss is prolonged—lasting more than a couple of weeks—or occurs alongside other symptoms like unexplained weight loss, nausea, or abdominal discomfort, it may indicate a more serious underlying condition.

If you find that you are consistently uninterested in eating, skipping meals, or feeling repulsed by food without a clear cause, it is important to take this symptom seriously. Early medical evaluation is recommended to determine the cause and initiate appropriate care. For more information, see the American Cancer Society’s overview of stomach cancer symptoms.

10. Heartburn That Won’t Go Away

Persistent heartburn is more than just an occasional annoyance—it can be a warning sign of a deeper health issue, including stomach cancer. Heartburn occurs when stomach acid backs up into the esophagus, causing a burning sensation in the chest or throat. While most people experience mild heartburn after eating spicy or acidic foods, drinking alcohol, or lying down too soon after meals, these episodes typically resolve with antacids or lifestyle adjustments.

When heartburn becomes chronic, frequent, or resistant to over-the-counter medications, it may indicate more than just typical acid reflux (gastroesophageal reflux disease, or GERD). In rare cases, stomach tumors can alter the stomach’s structure or function, leading to increased acid production or impaired emptying. This can result in persistent heartburn that does not improve with usual remedies. People may also notice associated symptoms such as persistent cough, sore throat, or difficulty swallowing.

If you find yourself relying on heartburn medication regularly or if your symptoms persist for several weeks despite treatment, it is important to consult a healthcare provider. Early diagnosis can lead to improved outcomes. For more on this warning sign, refer to the American Cancer Society’s stomach cancer symptoms page.

11. Black or Tarry Stools

Black or tarry stools—medically known as melena—can be a significant sign of gastrointestinal bleeding, often resulting from stomach cancer. When blood is lost from the upper digestive tract, such as the stomach, digestive enzymes break it down, causing the stool to appear black and sticky rather than red. This symptom is particularly concerning when it occurs repeatedly or is accompanied by other warning signs like abdominal pain, anemia, or unexplained fatigue.

It’s important to note that not all dark stools are caused by internal bleeding. Certain foods, such as black licorice, blueberries, or iron supplements, can also darken stool color temporarily. However, melena typically has a distinctive, foul odor and a tar-like consistency, which are not seen with food-related color changes. If you notice black or tarry stools without a clear dietary explanation, especially if the change is persistent, it should not be ignored.

Prompt medical attention is necessary if you experience melena, as it may indicate ongoing bleeding and a risk for anemia or more severe complications. For further information on this symptom and recommended steps, visit the American Cancer Society’s stomach cancer symptoms resource.

12. Fatigue That Lingers

Chronic fatigue is a common but often underestimated symptom of stomach cancer. While everyone experiences tiredness from time to time—usually due to a busy lifestyle, inadequate sleep, or physical exertion—cancer-related fatigue is different in both intensity and persistence. In stomach cancer, fatigue can result from internal blood loss leading to anemia, the body’s inflammatory response to cancer, or the tumor’s consumption of the body’s energy resources.

Unlike ordinary tiredness, cancer-related fatigue does not resolve with rest or sleep and tends to worsen over time. People may notice a profound lack of energy that interferes with daily activities, hobbies, or even basic self-care. This level of fatigue is not proportional to recent exertion and is often described as overwhelming or debilitating. Chronic fatigue may also coexist with other symptoms such as pallor, shortness of breath, or unexplained weight loss.

If you find yourself struggling with persistent, unexplained fatigue—especially if it lingers for weeks despite rest and healthy habits—it is vital to consult a healthcare provider. Early assessment can help uncover underlying causes, including serious conditions like stomach cancer. For more information, consult the Cancer.Net stomach cancer symptoms guide.

13. Swelling or Fluid in the Abdomen

Abdominal swelling or the accumulation of fluid in the abdomen, known as ascites, can occur in advanced stages of stomach cancer. This condition develops when cancer cells irritate the lining of the abdominal cavity or block lymphatic drainage, causing fluid to leak and collect in the space around the organs. Unlike common bloating, which comes and goes with diet or digestion, ascites leads to noticeable and persistent abdominal distension. The abdomen may feel tight or heavy, and the swelling often does not fluctuate significantly throughout the day.

Ascites can cause discomfort, difficulty breathing, or a sense of fullness that makes eating difficult. Whereas ordinary bloating is usually linked to food choices, digestive issues, or gas, ascites is usually more pronounced and less responsive to dietary changes or over-the-counter remedies. Ascites may also be accompanied by other warning signs like unexplained weight gain, rapid abdominal growth, or leg swelling.

If you experience persistent or rapidly worsening abdominal swelling, particularly if it is associated with other symptoms like pain, weight loss, or fatigue, it is important to seek prompt medical evaluation. For more about ascites and cancer, visit the American Cancer Society’s stomach cancer symptoms page.

14. Difficulty Swallowing

Difficulty swallowing, known as dysphagia, can be a concerning symptom when it arises suddenly or persists over time. In stomach cancer, especially when tumors are located near the gastroesophageal junction (where the esophagus meets the stomach), the passage of food can become obstructed. This obstruction can make it hard for food and liquids to move smoothly from the throat into the stomach, causing a sensation of food sticking, choking, or discomfort while swallowing.

Temporary swallowing difficulties can occur from causes such as eating too quickly, throat infections, or minor esophageal irritation. These episodes are usually brief and resolve with time or simple interventions like drinking water or eating slowly. However, dysphagia linked to stomach cancer typically worsens progressively, starting with difficulty swallowing solid foods and eventually affecting liquids as well.

If you notice persistent or worsening difficulty swallowing, especially if accompanied by weight loss, pain, or regurgitation of food, it is crucial to seek medical attention for further assessment. Early evaluation can help identify the underlying cause and allow for timely treatment. For a detailed discussion on dysphagia and stomach cancer, visit the American Cancer Society’s symptom overview.

15. Unexplained Fever

Unexplained low-grade fevers can sometimes be associated with stomach cancer, though they are less common than other gastrointestinal symptoms. Cancer-related fevers are typically persistent and mild, often hovering just above normal body temperature without an obvious cause such as infection or recent illness. These fevers may be caused by the cancer itself releasing inflammatory substances, or by the body’s immune response to the tumor’s presence.

Unlike fevers from infections, which are usually higher in temperature, come on suddenly, and are often accompanied by chills, body aches, or sore throat, cancer-related fevers tend to be subtler and more long-lasting. Sometimes, these fevers may come and go but persist over weeks or months without a clear pattern. People may also notice night sweats, fatigue, or general malaise in conjunction with the fever.

If you experience a persistent, unexplained fever for more than a week—especially if it is accompanied by symptoms like weight loss, fatigue, or digestive changes—it is important to document your temperatures and share this information with your healthcare provider. Early investigation can help rule out infections and identify any serious underlying conditions. For more, see the Cancer.Net stomach cancer symptoms guide.

16. Frequent Belching

Frequent belching, or burping, is a natural process that helps release swallowed air from the digestive tract. However, when belching becomes unusually persistent or excessive, it may be a sign of an underlying problem, including stomach cancer. Tumors in the stomach can disrupt normal digestive processes by causing partial obstruction, slowing gastric emptying, or increasing the buildup of gas. As a result, individuals may notice they are belching far more often than usual, even without obvious dietary triggers.

Dietary causes of belching are generally benign and include eating or drinking too quickly, consuming carbonated beverages, or eating foods that produce gas such as beans or onions. In these cases, belching tends to subside once eating habits are adjusted or gas-producing foods are limited. In contrast, belching linked to stomach cancer is less likely to improve with changes in diet and often occurs alongside other symptoms such as persistent indigestion, bloating, or unexplained weight loss.

If you find yourself experiencing frequent, unexplained belching—especially when accompanied by other gastrointestinal symptoms—it may warrant further medical evaluation. For more information on digestive symptoms and when they could indicate cancer, visit the Cancer Research UK stomach cancer symptoms page.

17. Pale Skin

Pale skin, or pallor, is a physical sign that may indicate anemia, which can develop from chronic blood loss associated with stomach cancer. As tumors erode the stomach lining or blood vessels, slow but persistent bleeding may occur, eventually depleting the body’s red blood cell supply. This reduction in circulating red blood cells and hemoglobin decreases the oxygen delivered to tissues, resulting in a visibly lighter or washed-out appearance of the skin and mucous membranes (such as the inside of the mouth or lower eyelids).

It’s important to distinguish cancer-related pallor from the natural variations in skin tone and color that are determined by genetics, sun exposure, or temporary factors like cold weather. Unlike these normal changes, pallor from anemia is often accompanied by other symptoms, such as persistent fatigue, shortness of breath, dizziness, or rapid heartbeat. The change in skin color may be subtle and develop gradually, making it easy to overlook unless you are monitoring for other warning signs.

If you or those around you notice a persistent paleness, especially if it is new or accompanied by additional symptoms, it is important to seek medical advice and consider a blood test. For more information, visit the American Cancer Society’s stomach cancer symptoms page.

18. Vomiting Blood

Vomiting blood, medically termed hematemesis, is a serious symptom that can be associated with stomach cancer. When a tumor erodes the stomach lining or blood vessels, it may cause bleeding that is expelled through vomiting. The appearance of the vomit can range from bright red blood to dark, coffee-ground-like material, the latter indicating partially digested blood. This is a medical emergency and should never be ignored.

While hematemesis can also result from less serious causes such as gastric or duodenal ulcers, severe gastritis, or certain medications, the presence of blood in vomit always warrants immediate investigation. Unlike ulcers, which often have a history of burning pain relieved by food or antacids, stomach cancer-related bleeding may occur with more subtle or persistent symptoms, including weight loss, fatigue, or early satiety.

Anyone experiencing vomiting of blood, regardless of color or quantity, should seek emergency medical care right away. Prompt diagnosis and intervention are crucial to managing the bleeding and addressing the underlying cause. For more detailed information on this symptom and other signs of stomach cancer, visit the Cancer Research UK stomach cancer symptoms resource.

19. Sudden Aversion to Certain Foods

Developing a sudden aversion to specific foods can be an unusual but telling symptom of stomach cancer. Tumors may alter the body’s metabolism and affect the senses of taste and smell, leading to a dislike or repulsion toward foods that were once enjoyed. In some cases, cancer-related inflammation or chemicals released by the tumor can directly influence taste receptors or create a metallic taste in the mouth, making eating certain foods—especially meat or rich dishes—unpleasant.

Food aversions are also common during pregnancy or with some medications, but these are generally temporary and have clear, benign causes. In pregnancy, for example, hormonal changes typically drive aversions and cravings, which often resolve after a few weeks or months. By contrast, aversions linked to stomach cancer may appear suddenly, persist, and worsen over time. These changes are often accompanied by additional symptoms like loss of appetite, nausea, or unexplained weight loss.

If you notice a sudden, sustained aversion to foods without an obvious reason—and especially if it is accompanied by other digestive or systemic symptoms—it is wise to seek medical advice for further assessment. For more on how cancer can affect appetite and taste, visit the American Cancer Society’s guide on appetite and taste changes in cancer.

20. Unusual Back Pain

Unusual or persistent back pain can sometimes be a symptom of stomach cancer, particularly when the cancer spreads beyond the stomach or irritates nearby nerves. This type of pain is known as referred pain, where discomfort originating in one part of the body is felt in another. When tumors invade the lining of the stomach or surrounding tissues, they can trigger nerve pathways that lead to pain in the mid or upper back.

Muscular back pain is typically the result of physical strain, poor posture, or injury, and is often relieved by rest, stretching, or over-the-counter pain medication. It is usually localized, may fluctuate with movement, and often improves within days or weeks. In contrast, back pain related to stomach cancer tends to be persistent, deep, and not clearly linked to physical activity or injury. It may worsen over time and is often accompanied by other symptoms such as unexplained weight loss, fatigue, or digestive changes.

If you experience new, persistent, or unexplained back pain—especially when it occurs with other gastrointestinal or systemic symptoms—it is important to consult a healthcare professional. For more information, review the Cancer.Net stomach cancer symptoms page.

21. Jaundice

Jaundice is characterized by the yellowing of the skin and the whites of the eyes. In advanced cases of stomach cancer, this occurs when a tumor spreads to the liver or blocks the bile ducts, preventing bile from draining properly. As a result, bilirubin—a yellow pigment produced during the breakdown of red blood cells—accumulates in the bloodstream and tissues, leading to the visible yellow discoloration. This symptom is most often seen when stomach cancer has metastasized or is pressing on nearby liver and bile ducts.

Jaundice can also be caused by other medical conditions, most notably hepatitis, gallstones, or certain genetic disorders. In hepatitis, jaundice is often accompanied by flu-like symptoms, dark urine, and pale stools, and it is usually linked to liver inflammation or infection. In contrast, jaundice from stomach cancer is more likely to be associated with additional signs of advanced disease, such as weight loss, abdominal pain, or swelling.

Any sudden onset of jaundice—especially when accompanied by other alarming symptoms—requires urgent medical evaluation. Early diagnosis can help determine the cause and guide appropriate treatment. For more information, consult the American Cancer Society’s stomach cancer symptoms resource.

22. Swollen Lymph Nodes

Swollen lymph nodes can be a significant sign of stomach cancer, especially when the swelling occurs in specific areas such as above the collarbone (known as Virchow’s node). Lymph nodes are small, bean-shaped structures that help filter harmful substances and play a key role in the immune response. When cancer cells spread from the stomach, they may travel to regional lymph nodes, causing them to become enlarged, firm, and sometimes painless.

Lymph node swelling is also common in response to infections, such as a cold, sore throat, or localized skin infection. In these cases, the swelling is usually tender, soft, and resolves as the infection clears. In contrast, cancer-related lymph node enlargement tends to persist, is often non-tender, and may progressively increase in size. Swelling above the left collarbone is particularly noteworthy, as it can be an early sign of advanced gastrointestinal malignancy.

If you notice a persistent, hard, or growing lump in your neck, armpit, or above your collarbone—especially if it is not associated with recent illness—it is important to seek a medical evaluation. Early detection can significantly impact treatment options and outcomes. For further details, visit the Cancer.Net guide to stomach cancer symptoms.

23. Loss of Muscle Mass

Loss of muscle mass, also known as cachexia, is a common complication in advanced stomach cancer. Cachexia involves the involuntary wasting of both muscle and fat tissue, resulting in noticeable weakness and physical decline. Unlike the gradual, controlled weight loss that occurs with healthy dieting or increased exercise, cancer-related muscle loss is unintentional, more rapid, and often occurs even when calorie intake remains steady or only slightly reduced.

This muscle wasting occurs because cancer cells release substances that disrupt normal metabolism and increase the body’s breakdown of muscle proteins. Patients may observe shrinking muscles in the arms, legs, or face, and experience fatigue, reduced strength, and diminished ability to perform daily activities. Unlike weight loss from dieting—where fat loss is usually more pronounced and muscle can often be preserved with exercise—cachexia is marked by the significant and progressive loss of muscle bulk, which is difficult to reverse without treating the underlying cancer.

If you or someone close to you notices sudden or unexplained muscle wasting, particularly when accompanied by other symptoms like fatigue, loss of appetite, or weight loss, it is important to seek prompt medical evaluation. For more on cachexia and cancer, visit the American Cancer Society’s information page on appetite loss and muscle wasting.

24. Change in Bowel Habits

A change in bowel habits—such as developing new, persistent constipation or diarrhea—can be a subtle yet significant symptom of stomach cancer. Tumors in the stomach can interfere with normal digestion and absorption, sometimes leading to irregularities in how waste moves through the gastrointestinal tract. For example, a partial blockage or irritation caused by a tumor may slow down bowel movements, resulting in constipation, or speed up transit, causing diarrhea.

It’s common for bowel habits to fluctuate temporarily due to dietary changes, travel, stress, or minor gastrointestinal infections. These routine changes are usually short-lived and resolve within a few days. In contrast, cancer-related changes tend to persist, worsen over time, and may not respond to typical over-the-counter remedies. Additional symptoms such as abdominal pain, blood in the stool, or unexplained weight loss can further indicate a more serious underlying issue.

If you notice a lasting change in your bowel habits—such as ongoing constipation, diarrhea, or alternating between both—especially if these changes are new for you and last more than a few weeks, it is important to track them and consult a healthcare provider. For more on digestive changes and cancer, visit the American Cancer Society’s stomach cancer symptoms resource.

25. Skin Changes Around the Belly

Although uncommon, certain skin changes around the abdomen can serve as external clues to underlying stomach cancer. One such sign is the appearance of firm, painless nodules under the skin of the belly, known as Sister Mary Joseph nodules. These nodules represent metastases—cancer cells that have spread from the stomach to the skin near the umbilicus (navel). The affected area may become raised, discolored, or feel different to the touch compared to surrounding skin. Other rare skin manifestations may include persistent redness, swelling, or ulceration.

It is important to distinguish these cancer-related skin changes from more common skin conditions such as cysts, lipomas (benign fatty lumps), rashes, or infections. While benign conditions are usually not associated with systemic symptoms and often resolve with basic treatment, skin changes linked to cancer tend to persist and may be accompanied by other warning signs like unexplained weight loss, fatigue, or abdominal discomfort.

If you notice any new, persistent, or unusual skin changes around your belly—especially firm nodules or lumps—it is crucial to report them to your healthcare provider promptly for evaluation. For more insight into skin changes and cancer, see the Cancer Research UK stomach cancer symptoms page.

26. Unrelenting Hiccups

While hiccups are usually a harmless annoyance that resolve within minutes, persistent or unrelenting hiccups can sometimes be linked to more serious conditions, including stomach cancer. Tumors in the upper stomach or areas near the diaphragm may irritate the phrenic or vagus nerves, which play a key role in controlling the diaphragm’s movement. This irritation can trigger repeated, involuntary contractions of the diaphragm, resulting in ongoing or severe hiccups that are difficult to control.

Normal hiccups are most often caused by eating too quickly, consuming carbonated beverages, sudden temperature changes, or excitement. These episodes are typically brief and resolve on their own or with simple home remedies. In contrast, cancer-related hiccups tend to last longer than 48 hours, recur frequently, and may not respond to typical interventions. They can significantly interfere with eating, sleeping, and overall quality of life.

If you experience hiccups that persist for more than two days, especially when accompanied by other symptoms such as difficulty swallowing, unexplained weight loss, or abdominal pain, it is important to seek medical attention. Persistent hiccups can be an important clue for underlying disease. For more about this symptom, visit the Cancer.Net stomach cancer symptoms page.

27. Feeling Faint or Dizzy

Feeling faint or dizzy is a symptom that can arise from various causes, but when persistent, it may indicate underlying anemia or blood loss due to stomach cancer. Chronic bleeding from a tumor in the stomach can gradually decrease the number of healthy red blood cells, resulting in low hemoglobin levels and reduced oxygen delivery to the brain. This can lead to episodes of lightheadedness, dizziness, or even fainting, especially when standing up quickly or engaging in physical activity.

Dehydration is another common cause of dizziness, often resulting from inadequate fluid intake, excessive sweating, or acute illness. In these scenarios, dizziness typically improves with rest and rehydration. In contrast, anemia-related dizziness from cancer is less likely to resolve with fluids alone and often becomes more noticeable over time. It may be accompanied by additional symptoms such as fatigue, pale skin, rapid heartbeat, or shortness of breath.

If you experience ongoing or unexplained episodes of dizziness or faintness—particularly if they are new, recurrent, or associated with other warning signs—it is important to monitor your symptoms and seek medical evaluation. For more on anemia, dizziness, and their connection to cancer, visit the American Cancer Society’s stomach cancer symptoms resource.

28. Persistent Bad Breath

Persistent bad breath, or halitosis, can occasionally be a sign of stomach cancer, particularly when tumors partially obstruct the stomach and interfere with normal digestion. As food sits longer in the stomach due to an obstruction, it can ferment and produce foul-smelling gases that are eventually expelled through the mouth. This type of halitosis often has a distinct, unpleasant odor that does not improve with regular oral hygiene practices.

Most cases of bad breath are related to dental issues, gum disease, dry mouth, or certain foods like garlic and onions. These causes are typically managed with improved oral care, hydration, and dietary changes. However, when halitosis persists despite proper dental hygiene or occurs alongside other digestive symptoms—such as nausea, indigestion, unexplained weight loss, or vomiting—it may point to a problem deeper in the gastrointestinal tract.

If you experience ongoing bad breath that does not respond to brushing, flossing, or mouthwash, especially in combination with other gastrointestinal complaints, it is advisable to consult a healthcare provider for further evaluation. For more on digestive causes of halitosis and cancer, visit the Cancer Research UK stomach cancer symptoms page.

29. Early Morning Nausea

Experiencing nausea first thing in the morning, before eating or drinking, can be an early symptom of stomach cancer. Tumors in the stomach may release substances that irritate the stomach lining overnight or slow gastric emptying, resulting in a queasy feeling upon waking. This symptom can occur even without obvious dietary triggers or recent illness, and may gradually worsen or become more frequent over time.

Morning nausea is also commonly associated with pregnancy—especially during the first trimester—due to hormonal changes. In pregnancy, however, nausea is often accompanied by missed periods and other classic signs and tends to resolve as the pregnancy progresses. In contrast, cancer-related morning nausea may persist for weeks or months, and is often accompanied by other digestive symptoms such as loss of appetite, unintentional weight loss, or abdominal discomfort.

The timing of nausea can provide important diagnostic clues. Persistent nausea that occurs primarily in the morning, especially when not explained by pregnancy or another clear cause, should not be overlooked. If you regularly wake up feeling nauseous, particularly alongside other warning signs, it is important to seek medical attention. For more information, visit the American Cancer Society’s stomach cancer symptoms resource.

30. Stomach Lump or Mass

Feeling a lump or mass in the stomach area can be an alarming symptom and may indicate the presence of a tumor arising from the stomach or nearby organs. In some cases of advanced stomach cancer, the tumor grows large enough to be felt through the abdominal wall during self-examination or a physical exam by a healthcare professional. This lump may feel firm, irregular, and is often painless, though discomfort can occur as the mass enlarges or presses on surrounding tissues.

It’s important to differentiate cancer-related lumps from benign cysts, fatty lumps (lipomas), or hernias, which are common and typically harmless. Benign lumps are usually soft, moveable, and do not grow rapidly, while tumors associated with stomach cancer are more likely to be fixed, firm, and may increase in size over a short period.

If you notice a new, persistent, or growing lump in your abdomen—especially if it is accompanied by other symptoms like unexplained weight loss, digestive changes, or pain—it is essential to seek medical attention for prompt evaluation. Early assessment can help determine the cause and improve treatment outcomes. For more about abdominal lumps and cancer, see the Cancer Research UK stomach cancer symptoms guide.

31. Unusual Taste in Mouth

An unusual taste in the mouth, often described as metallic, bitter, or unpleasant, can sometimes be linked to stomach cancer. Tumors may release chemicals or inflammatory substances that alter taste perception, or they may interfere with digestive processes, leading to changes in the flavors experienced after eating or drinking. This phenomenon, known as dysgeusia, can make foods and beverages taste abnormal and contribute to loss of appetite or aversion to eating.

Many people experience temporary changes in taste due to medication side effects, such as antibiotics, certain blood pressure medicines, or chemotherapy. These medication-related taste disturbances typically resolve after stopping the drug. In contrast, taste changes associated with stomach cancer are more likely to persist, worsen over time, and remain unexplained by other factors. Persistent dysgeusia may also be accompanied by other symptoms, such as nausea, early satiety, or unexplained weight loss.

If you notice a lasting metallic, bitter, or otherwise unusual taste in your mouth—especially when it cannot be linked to recent medication changes or dental issues—it is important to discuss this symptom with your healthcare provider. For more on taste changes and cancer, see the American Cancer Society’s page on taste and appetite changes.

32. Persistent Cough

A persistent cough that lasts for several weeks or longer can occasionally be associated with advanced stomach cancer. Tumors located near the top of the stomach or those that have spread (metastasized) to the lungs or lymph nodes may press on the diaphragm or irritate the airway, triggering a chronic cough. This cough is often dry and unproductive, though it can occasionally bring up small amounts of sputum. In some cases, the cough may worsen after eating or lying down, as the tumor’s location increases pressure on surrounding tissues.

Most coughs are related to respiratory infections like the common cold or flu and typically resolve within a week or two as the illness clears. Allergies, postnasal drip, or mild acid reflux can also cause temporary coughing. However, a cough associated with cancer is usually persistent, is not relieved by standard treatments, and may be accompanied by other symptoms such as unexplained weight loss, hoarseness, or difficulty swallowing.

If you develop a cough that lingers beyond three weeks—especially if it is new, worsening, or associated with other concerning symptoms—it is important to have it evaluated by a healthcare professional. For more about persistent cough as a symptom, visit the Cancer.Net stomach cancer symptoms guide.

33. Frequent Stomach Infections

Frequent stomach infections, such as recurring bouts of gastritis or gastroenteritis, can occasionally signal an underlying problem like stomach cancer. Cancer may weaken the local immune defenses of the stomach lining, making it easier for bacteria, such as Helicobacter pylori, or viruses to take hold and cause symptoms. The tumor’s presence can disrupt the normal acidic environment or create areas of chronic inflammation, further impairing the stomach’s ability to ward off infections.

Typical stomach bugs are usually caused by contaminated food or water and result in symptoms such as nausea, vomiting, diarrhea, and stomach cramps that resolve within a few days. Most people recover quickly and experience only occasional episodes. In contrast, individuals with stomach cancer may notice a persistent or recurrent pattern of infections, with symptoms that are more severe, last longer, or recur soon after apparent recovery. These infections may also be accompanied by other concerning signs like unexplained weight loss, fatigue, or persistent abdominal pain.

If you experience frequent or unusually severe stomach infections—especially if they follow a pattern or occur alongside other unusual symptoms—it is important to discuss this with your healthcare provider for further investigation. Learn more about the relationship between infections and stomach cancer at the Cancer Research UK stomach cancer causes page.

34. Changes in Voice

Changes in the voice, such as persistent hoarseness, can sometimes be an indirect symptom of stomach cancer. If a tumor near the top of the stomach or in nearby lymph nodes grows large enough, it can press on nerves that control the vocal cords, particularly the recurrent laryngeal nerve. This pressure may lead to a hoarse, raspy, or weak-sounding voice. In rare cases, cancer that has metastasized (spread) to the chest or neck area may also cause similar symptoms by affecting these nerves.

Most voice changes are benign and result from common conditions like colds, upper respiratory infections, allergies, or overuse (such as shouting or singing). These causes typically resolve within a week or two as the underlying issue clears. However, hoarseness related to cancer tends to persist for several weeks, is unrelated to recent illness or vocal strain, and may be accompanied by other symptoms such as difficulty swallowing, unexplained weight loss, or a persistent cough.

If you notice hoarseness or a change in your voice that lasts longer than two to three weeks—especially if it is unexplained and occurs with other warning signs—it is important to seek medical evaluation. For more information, visit the Cancer.Net stomach cancer symptoms guide.

35. Shoulder Pain

Shoulder pain is not commonly associated with stomach problems, but in rare cases, it may be a sign of referred pain from stomach cancer. When a tumor irritates or invades the diaphragm—the muscle that separates the chest and abdominal cavities—it can stimulate the phrenic nerve, which also transmits sensation to the shoulder region. This phenomenon, known as referred pain, means discomfort from the stomach or diaphragm is felt in the left or right shoulder, sometimes without obvious abdominal symptoms at first.

Most shoulder pain results from local issues such as muscle strain, rotator cuff injury, arthritis, or overuse. These causes are typically related to physical activity or injury and usually improve with rest, ice, or physical therapy. In contrast, referred shoulder pain from stomach cancer is often persistent, unexplained, and does not improve with conventional treatments for musculoskeletal injuries. It may also be accompanied by other warning signs, including abdominal pain, indigestion, unexplained weight loss, or fatigue.

If you experience new or persistent shoulder pain without a clear injury, especially in conjunction with digestive symptoms or systemic signs, it is important to seek prompt medical evaluation. For more information, see the Cancer.Net stomach cancer symptoms guide.

36. Night Sweats

Night sweats—episodes of excessive sweating during sleep—can sometimes be a systemic sign of underlying illnesses, including stomach cancer. In the context of cancer, night sweats are often triggered by the body’s immune response to tumor growth or by substances released by cancer cells that affect the body’s temperature regulation. Individuals may wake up with soaked clothing or bedding, even when the room temperature is comfortable and they have not been physically active during the night.

Night sweats can also result from benign causes such as hormonal fluctuations during menopause, infections like tuberculosis, anxiety, or certain medications. These episodes are often temporary and linked to specific changes in the body or environment. In contrast, night sweats associated with cancer are typically persistent, may worsen over time, and are frequently accompanied by other symptoms such as unexplained weight loss, persistent fever, or fatigue.

If you notice frequent, severe, or unexplained night sweats—especially when they occur alongside other warning signs—it is important to monitor their frequency and severity and discuss them with a healthcare professional. Early evaluation can help identify the underlying cause. For more information about night sweats and cancer, visit the Cancer.Net stomach cancer symptoms guide.

37. Decreased Urine Output

Decreased urine output can be a serious sign in individuals with advanced stomach cancer. As the disease progresses, patients may experience severe dehydration due to persistent vomiting, poor fluid intake, or significant gastrointestinal losses. Additionally, the body’s metabolic response to cancer can put extra strain on the kidneys, further reducing their ability to filter waste and regulate fluid balance. This combination can lead to noticeably less frequent urination or smaller volumes of urine, which may appear darker in color.

Lower urine output can also result from other common causes such as acute illnesses with fever, diarrhea, or excessive sweating, as well as conditions like urinary tract infections or the use of certain medications. In these cases, urine output typically returns to normal as the underlying issue resolves and hydration is restored. In contrast, persistent or worsening oliguria (low urine output) in the context of cancer may signal severe dehydration, kidney dysfunction, or multi-organ involvement.

If you observe a significant or ongoing reduction in urine output—especially if accompanied by other signs such as confusion, swelling, or fatigue—it is crucial to report this promptly to a healthcare provider. For more on kidney function and cancer symptoms, consult the American Cancer Society’s stomach cancer symptoms resource.

38. Itchy Skin

Itchy skin, medically known as pruritus, can sometimes be a symptom of advanced stomach cancer, particularly if the cancer has spread to the liver or is causing bile duct obstruction. When the flow of bile is blocked, bile salts and bilirubin build up in the bloodstream and are deposited in the skin, triggering persistent or widespread itching. This type of itch often does not respond to typical skin care measures and may be accompanied by other symptoms such as jaundice (yellowing of the skin and eyes) and dark urine.

In contrast, most cases of itchy skin result from benign causes such as dry weather, allergies, skin irritants, or conditions like eczema. These types of itching are usually localized, improve with moisturizers or antihistamines, and are not associated with systemic symptoms. However, cancer-related pruritus tends to be more diffuse, persistent, and may worsen over time.

If you experience unexplained, widespread, or persistent itching—especially if it is accompanied by changes in skin color, fatigue, or other signs of liver dysfunction—it is important to discuss this with your healthcare provider. For more information about pruritus and its connection to cancer, visit the American Cancer Society’s stomach cancer symptoms page.

39. Reduced Ability to Exercise

A noticeable reduction in the ability to exercise or perform physical activities can be an early warning sign of stomach cancer. As the disease progresses, the body’s energy reserves are depleted due to factors such as chronic blood loss, anemia, poor nutrient absorption, and cancer-related fatigue. This can lead to a marked decline in stamina, endurance, and overall physical strength, making everyday tasks or exercise routines feel significantly more challenging.

While a gradual decrease in exercise capacity is common with advancing age or after periods of inactivity, this type of decline is typically slow and can often be improved with regular training and a healthy lifestyle. In contrast, a sudden or unexplained drop in exercise tolerance—where activities that were previously easy become difficult or exhausting—may signal an underlying medical issue, such as cancer, heart disease, or severe anemia. Additional symptoms like shortness of breath, rapid heartbeat, dizziness, or unexplained weight loss may further indicate a serious cause.

If you experience a sudden or persistent decrease in your ability to exercise, especially in the absence of changes to your routine or lifestyle, it is important to seek medical evaluation. For more on the impact of cancer on physical activity, visit the American Cancer Society’s stomach cancer symptoms resource.

40. Frequent Burping After Meals

Frequent burping after meals can be more than just an inconvenience and, in some cases, may be linked to underlying stomach cancer. Tumors in the stomach can interfere with normal gastric function, slow down the emptying of food, or partially block the passage of food and gas. This disruption can lead to increased gas buildup and the need to burp repeatedly, particularly after eating. The burping may be accompanied by other symptoms such as bloating, early satiety, nausea, or abdominal discomfort.

Most cases of post-meal burping are harmless and result from swallowing air while eating or drinking quickly, or from consuming carbonated beverages and gas-producing foods. These forms of burping are typically short-lived and can often be resolved by changing eating habits or avoiding certain foods. However, persistent or excessive burping after every meal that does not improve with dietary changes may be a signal of digestive tract issues, including the presence of a tumor.

If you notice a pattern of frequent burping after meals, especially if it is accompanied by unexplained weight loss, indigestion, or other digestive symptoms, you should seek medical evaluation. For more on digestive symptoms and cancer, visit the Cancer Research UK stomach cancer symptoms guide.

41. Unusual Food Cravings or Aversions

Unusual food cravings or sudden aversions can sometimes be related to the metabolic changes caused by stomach cancer. As tumors affect the body’s ability to process nutrients, they may release chemicals that disrupt normal hunger and satiety signals, leading to cravings for certain foods or, conversely, a strong dislike for foods that were previously enjoyed. This phenomenon can also be influenced by changes in taste perception, nausea, or digestive discomfort triggered by the cancer’s impact on the gastrointestinal system.

During pregnancy, food cravings and aversions are common and attributed to hormonal shifts. These preferences are generally benign, temporary, and often fluctuate throughout pregnancy. In contrast, cravings or aversions linked to stomach cancer typically appear suddenly in adults who are not pregnant, persist over time, and may be accompanied by other symptoms such as unexplained weight loss, loss of appetite, or ongoing nausea.

If you experience new, persistent cravings or strong aversions to foods without an obvious cause—and especially if these changes are coupled with other digestive or systemic symptoms—it is important to discuss them with your healthcare provider. For more insight into appetite and dietary changes in cancer, visit the American Cancer Society’s guide to appetite and taste changes.

42. Hiccups That Won’t Stop

Hiccups are a common, usually harmless reflex involving sudden contractions of the diaphragm, often triggered by eating too quickly, drinking carbonated beverages, or experiencing excitement or stress. Most episodes of hiccups last only a few minutes and resolve spontaneously or with simple home remedies. However, when hiccups persist for more than 48 hours or recur frequently without an obvious cause, they may be a rare but important warning sign of an underlying health issue, including stomach cancer.

Persistent or intractable hiccups can occur when a tumor in the upper stomach or nearby areas irritates the diaphragm or the nerves that control it, such as the phrenic or vagus nerves. This ongoing irritation causes repeated, involuntary contractions that do not respond to usual interventions. Unlike benign hiccups, these episodes can interfere with eating, sleeping, and overall quality of life, and may be accompanied by additional symptoms like nausea, weight loss, or abdominal discomfort.

If you develop hiccups that last longer than two days or are accompanied by other unexplained symptoms, it is crucial to seek medical evaluation. Early investigation can help pinpoint the underlying cause. For more, visit the Cancer.Net stomach cancer symptoms guide.

43. Bloating After Small Meals

Experiencing bloating or a sensation of being overly full after eating only a small meal can be an early and significant symptom of stomach cancer. This feeling, known as early satiety, occurs when a tumor reduces the stomach’s capacity or interferes with normal digestive processes, preventing the stomach from expanding as it should. As a result, even light meals can lead to uncomfortable bloating, pressure, or the urge to stop eating sooner than usual.

Bloating after overeating or consuming gas-producing foods is common and typically short-lived, resolving as digestion progresses. In these benign cases, bloating is often tied to specific dietary habits or occasional indulgence. However, persistent bloating after small meals, especially when not linked to dietary changes, is more concerning and may point to a physical obstruction or impaired stomach function caused by a tumor.

If you notice ongoing bloating or fullness after eating only a little, particularly if it is new, worsening, or associated with other symptoms such as weight loss, loss of appetite, or abdominal pain, it is important to consult a healthcare provider. For more information about digestive symptoms and their significance, visit the American Cancer Society’s stomach cancer symptoms guide.

44. New Intolerance to Alcohol

Developing a new intolerance to alcohol—where even small amounts cause discomfort, nausea, or flushing—can be a subtle sign of stomach cancer. Tumors and inflammation in the stomach lining may alter the way the body processes alcohol, making the stomach more sensitive to its effects. Alcohol can further irritate the already compromised stomach lining, leading to symptoms such as burning pain, indigestion, or a rapid onset of nausea after drinking, even when previously well-tolerated.

Ordinarily, alcohol tolerance is influenced by factors like body weight, genetics, frequency of consumption, and overall health. A gradual decrease in tolerance is common with aging or reduced drinking frequency. However, a sudden or marked change in how the body handles alcohol, particularly when associated with gastrointestinal symptoms, should not be ignored.

If you begin experiencing new or worsening symptoms after consuming even small amounts of alcohol—such as abdominal pain, immediate nausea, or facial flushing—and especially if these changes are accompanied by other digestive complaints or unexplained weight loss, it is important to seek medical advice. For more information about gastrointestinal symptoms and their connection to cancer, visit the American Cancer Society’s stomach cancer symptoms page.

45. Visible Veins on Abdomen

The sudden appearance of prominent, visible veins on the abdomen can be a sign of underlying medical issues, including advanced stomach cancer. When a tumor spreads to the liver or obstructs blood flow in the portal vein (a major vessel supplying the liver), it can cause a condition known as portal hypertension. This increased pressure forces blood to find alternative pathways, leading to the development of engorged, winding veins visible beneath the skin of the abdomen—sometimes described as a “caput medusae” pattern.

Some people naturally have visible veins on their bodies due to genetics, thin skin, or increased physical activity, and these are typically harmless and unchanged over time. However, newly appearing or rapidly expanding veins, especially when associated with other symptoms such as jaundice, abdominal swelling, or unexplained weight loss, warrant closer attention. Portal hypertension may also lead to other complications like fluid buildup (ascites) or gastrointestinal bleeding.

If you notice new or increasing visibility of veins on your abdomen, especially in combination with other changes in your health, it is important to consult a healthcare provider for a thorough evaluation. For more about abdominal symptoms and liver involvement in stomach cancer, see the American Cancer Society’s stomach cancer symptoms page.

46. Difficulty Digesting Fatty Foods

Difficulty digesting fatty foods is a symptom that can arise when stomach cancer blocks or compresses the bile ducts or affects nearby organs like the liver or pancreas. Bile, produced by the liver and stored in the gallbladder, is essential for breaking down dietary fats. When a tumor obstructs bile flow, the body cannot efficiently digest rich, fatty foods, resulting in symptoms such as bloating, greasy or pale stools, nausea, and abdominal discomfort shortly after eating.

This type of digestive difficulty is different from lactose intolerance, where the body lacks the enzyme needed to digest lactose in dairy products, causing gas, cramps, and diarrhea after consuming milk or cheese. While lactose intolerance symptoms are related specifically to dairy, issues with fatty foods in the context of cancer are linked to compromised bile flow and are often persistent, regardless of dietary changes.

If you notice ongoing problems with digesting fatty or rich foods—such as feeling sick, bloated, or experiencing changes in stool appearance after meals—it could indicate a more serious underlying issue, especially if it is new or worsening. Persistent symptoms warrant prompt evaluation by a healthcare provider. For more on digestive changes and cancer, visit the American Cancer Society’s stomach cancer symptoms resource.

47. Unexplained Bruising

Unexplained bruising, especially when it occurs frequently or in unusual locations, can be a sign of underlying health issues, including stomach cancer. As cancer progresses, it can interfere with the body’s ability to produce blood-clotting factors, especially if the disease spreads to the liver, which is responsible for making many of these proteins. Additionally, chronic blood loss from a stomach tumor may lead to low platelet counts (thrombocytopenia), increasing the risk of easy bruising and bleeding.

Most bruises are the result of minor trauma or injury, such as bumping into furniture or engaging in physical activities, and are usually harmless. These bruises tend to heal within a week or two and are easily explained by recent events. In contrast, bruising related to cancer or clotting disorders is often spontaneous, occurs without clear cause, and may heal more slowly. You might also notice other signs, such as bleeding gums, frequent nosebleeds, or prolonged bleeding from small cuts.

If you start to experience frequent, severe, or unexplained bruising—especially if it is accompanied by fatigue, jaundice, or other systemic symptoms—it is important to seek medical evaluation. For further details, visit the American Cancer Society’s stomach cancer symptoms guide.

48. Swelling in the Legs

Swelling in the legs, also known as edema, can occur in individuals with advanced stomach cancer due to several mechanisms. One common cause is protein loss from chronic illness or malnutrition, which reduces the blood’s ability to retain fluid, allowing it to leak into the tissues of the lower limbs. Additionally, tumors may obstruct lymphatic vessels or major blood veins, hindering the normal return of fluid from the legs to the central circulation. This blockage can result in persistent swelling, most often in the ankles, feet, or calves.

Edema from injury, such as a sprained ankle, is generally localized to one area, associated with pain or bruising, and resolves as the injury heals. In contrast, cancer-related leg swelling is often symmetrical, involves both legs, and tends to persist or worsen over time. It may also be accompanied by other symptoms such as fatigue, shortness of breath, or abdominal swelling.

If you notice new, persistent, or worsening swelling in your lower extremities—especially if it cannot be explained by recent injury or physical strain—it is important to seek medical evaluation. For more on edema and its links to cancer, see the American Cancer Society’s stomach cancer symptoms resource.

49. Feeling Cold All the Time

Persistent chills or feeling cold all the time can be a subtle sign of underlying health problems, including stomach cancer. Cancer can disrupt the body’s metabolism and energy balance, making it harder to maintain a normal body temperature. In many cases, this sensation is linked to anemia, a common complication of stomach cancer caused by slow, chronic blood loss from the tumor. Anemia reduces the blood’s ability to carry oxygen, leading to symptoms such as cold intolerance, fatigue, and pale skin.

Feeling cold is also common in individuals with low body weight, hypothyroidism, or simple environmental exposure. These causes are generally temporary and often resolve with appropriate lifestyle changes or treatment. In contrast, cancer-related coldness tends to persist, is difficult to relieve with extra clothing or blankets, and may be accompanied by other symptoms like unexplained weight loss, weakness, or dizziness.

If you consistently feel cold despite warm surroundings and adequate clothing—especially if this is a new sensation or is associated with additional symptoms such as fatigue or pallor—it is important to discuss your concerns with a healthcare provider. For more on anemia, cold intolerance, and cancer, visit the American Cancer Society’s stomach cancer symptoms guide.

50. Sudden, Unexplained Depression or Mood Changes

Sudden, unexplained depression or mood changes can be a lesser-known symptom of serious medical conditions, including stomach cancer. The disease can have a profound psychological impact, not only because of the physical symptoms but also due to chemical changes in the body caused by chronic illness, inflammation, or nutritional deficiencies. These changes may disrupt neurotransmitter balance and hormone levels, contributing to feelings of sadness, irritability, anxiety, or loss of interest in activities that used to be enjoyable.

Situational depression usually follows a recognizable stressor—such as loss, life changes, or major setbacks—and tends to improve with time and support. In contrast, depression or mood changes associated with cancer may arise with no clear external trigger, persist despite supportive measures, and often coexist with physical symptoms like fatigue, appetite loss, or sleep disturbances. Patients may also withdraw from social activities or experience difficulty concentrating without understanding why.

If you or a loved one experiences sudden and persistent mood changes, especially in conjunction with other unexplained physical symptoms, it is important to seek a holistic evaluation from a healthcare provider. For more on the emotional impact of cancer and the importance of integrated care, visit the American Cancer Society’s guide to cancer and mental health.

Conclusion

Early recognition of stomach cancer’s warning signs is crucial, as many of its symptoms can be subtle and easily overlooked. The silent progression of this disease makes it particularly dangerous, often leading to late diagnoses and poorer outcomes. If you experience persistent or unexplained symptoms—such as changes in appetite, ongoing digestive issues, or unexplained weight loss—do not ignore them. Schedule an appointment with your healthcare provider or consider screening if you are at risk. Prompt evaluation can make a significant difference. For more guidance on screening and early detection, visit the American Cancer Society’s stomach cancer detection page.

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