24. When “Keeping It In The Family” Ends Up Being Detrimental
It’s a very sensitive topic to talk about, but incest occurs more often than people realize. That’s usually because it occurs when an older family member exerts power over a younger member of the family, resulting in the horrible case of incest occurring. tskir had to share the horrible story of the results of such a relationship when incest led to the birth of a child. There’s a reason that genetic diversity is important when it comes to having a baby.
“When the code ingested a genome sequencing sample, it attempted to detect the chromosomal sex of the patient. It used two metrics: the sample was considered female if it (1) lacked Y chromosome, and (2) was heterozygous on the X chromosome, implying there were two copies of it. Otherwise, the sample was considered male. This one sample registered as female on metric 1 (no Y chromosome) but male on metric 2 (very little heterozygocity on the X chromosome), which was not anticipated and resulted in our pipeline crashing. Upon investigation, it turned out that the parents of that poor girl were brother and sister to each other.”