Strange Syndromes and Disorders You Probably Haven’t Heard Of

14. Addison’s Disease Addison’s Disease is a disorder that affects the adrenal glands in the kidneys. It’s quite uncommon, but it does inhibit the body’s ability… Trista - August 9, 2022
Community Health Network

14. Addison’s Disease

Addison’s Disease is a disorder that affects the adrenal glands in the kidneys. It’s quite uncommon, but it does inhibit the body’s ability to produce certain hormones. These hormones are usually cortisol and aldosterone. Cortisol is the hormone released when a person is stressed; it releases sugar into the bloodstream and increases the ability of substances to repair damaged tissues. Aldosterone controls water and salts within the body; if it is too low, a person can experience dehydration, low sodium levels, and low blood pressure.

The American Journal of Medicine

Without treatment of Addison’s disease, the condition can become life-threatening. The typical cure is hormone replacement therapy to balance the body’s chemistry. Symptoms of the disease include weight loss and decreased appetite, extreme fatigue, the craving for salt, muscle/joint pains, body hair loss, depression, and irritability. In some cases, the symptoms of the disease can appear quite suddenly, called acute adrenal failure. Symptoms include confusion, severe abdominal pain, reduced consciousness, lower back or legs pain, and extreme weakness.

The Journal of Pediatrics and Pediatric Medicine

13. Congenital Insensitivity to Pain

Congenital insensitivity to pain may sound like a dream, not being able to experience pain, but the pain is essential to survival. Pain tells us when something is wrong with our bodies, and we should pain attention to it. Without pain, individuals would be completely unaware of their injuries, which can accumulate wounds, bruises, and even broken bones that they don’t even notice.

Jeff Merrell

Children with this condition tend to have wounds on their mouths and fingers from self-inflicted biting. Many people who have this condition will lose their sense of smell. The cause of this condition is peripheral neuropathy, which is damage to the nerves surrounding the brain and spinal cord that inhibit the sensations of touch, smell, and pain.

Daily Mail

12. Walking Corpse Syndrome

Walking Corpse Syndrome may be one of the strangest syndromes, but it really impacts people’s lives. Most people think it’s made up of people who want attention, but those with Walking Corpse Syndrome are seriously suffering. People with this condition are living with the delusions that they are truly dead: they believe they have no organs, blood, or body parts, even though they are still breathing. In the rarer cases, people start to think that they are actually immortal.


Those with Walking Corpse Syndrome also experience other mood or psychotic disorders. You may hear it called Cotard’s syndrome because Jules Cotard, a French neurologist, first examined it. He had a patient who insisted they had no organs and were missing certain body parts. As a result, they believed that they didn’t need to eat and passed away from starvation some time afterward.

New York Post

11. PGAD

This one is definitely one of the more jaw-dropping disorders. PGAD stands for Persistent genital arousal disorder; despite its name, it’s quite uncomfortable and debilitating. It occurs mostly in women, and many patients have reported that it is quite different from sexual arousal, and sex or masturbation doesn’t curtail the symptoms. It can cause quite a lot of distress in day-to-day life, but the problem is that it is still a poorly understood condition.


Because the symptoms continue for such an extended period with no means of relief or recourse, many people who live with the disorder tend to suffer from severe depression and may even feel suicidal. The only available treatments include lifestyle changes to minimize contact and blood flow to the genitals. This can include avoiding tight clothing, cycling, or prolonged sitting in one place. Pelvic physiotherapy can reduce the tension in the overactive pelvic muscles. You can minimize anxiety and keep the muscles throughout the body relaxed with meditation.

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10. Foreign Accent Syndrome

Foreign accent syndrome is incredibly rare, with only about 100 reported cases since 1907. It is a speech disorder characterized by sudden articulation and intonation that differs from how the person normally speaks. Simply put, the person develops a new accent altogether, even though they’ve never been to another country and would have never been exposed to this accent before. The pronunciation of words and vocabulary undergo drastic changes to the point that it sounds like a foreign accent to the listener, but it is not a true foreign accent.


Many scientists believe that this results from something in the brain since multiple areas are involved with speech. The foreign accent usually presents itself after there has been brain damage of some kind or there has been a psychiatric illness. Treatment involved typically looks to the original cause of the syndrome.

Almeyers Encyclopedia

9. Achard Thiers Syndrome

Achard-Thiers syndrome is also roughly known as diabetic bearded woman syndrome. This is because it primarily affects women in the postmenopausal stage who also live with type 2 diabetes. This disorder leads to the production of excess androgen, which is the hormone that is triggered when puberty hits. The most frequent signs of the syndrome include cravings for sugar, frequent urination, feeling anxiety, fatigue, lacking focus, weight loss, and difficulties concentrating.


Concerning androgen production, other symptoms can appear, such as infertility, obesity, receding hairline, increased body hair production, and a deepening of the voice. Treatments for the condition include healthier eating habits and exercise to keep diabetes under control, hormone therapy, and cosmetic removal of body hair.

The Conversation

8. Gigantism

Gigantism is characterized by excessive growth, making a person much taller than the average human. Some people can get up to nine feet tall! It results from a rare disorder that affects the growth hormone so that it never stops being produced. However, this constant release of this growth hormone occurs before the growth plate fuses, which can lead to painful joints and limbs. The enlarged body size tends to stress specific organs, such as the circulatory system and the heart.

Merck Manuals

The skeletal system is also affected; many who have gigantism tend to need help walking with a cane or some other mobility device. Studies show that most cases of gigantism result from a tumor growing on the pituitary gland within the brain. There are only a few cases where gigantism can be passed on through a mutated gene.

Pterygium. Medium.

7. Pterygium

Pterygium is also called a surfer’s eye and is a fleshy growth that appears on the eye’s conjunctive tissue. The leading cause of this disease is excessive exposure to UV light. Eyes can become red, swollen, and irritated. As the pterygium grows, it can impact vision, causing it to be blocked or blurred. However, the pterygium doesn’t continue to grow in all cases. Those most prone to pterygium are those who spend a lot of time outdoors, are exposed to a lot of UV light, and are primarily found in adults who live near the equator.

To help prevent eye ailments, always check in with your ophthalmologist. Shutterstock.

Usual signs include red and irritated eyes, slightly-raised pink growth, dry eyes, and the sensation of grit in the eye. As it continues, the growth can get bigger, and vision can be impacted over time. Most treatment options for pterygium include eye drops for lubrication and/or to reduce irritation and swelling. Doctors usually recommend surgery when vision starts to decline.

The Irish Sun

6. Exploding Head Syndrome

Exploding head syndrome is a real disorder that negatively impacts a person’s quality of life. In trying to fall asleep, a person’s systems start to slow into a state of rest. But for someone with exploding head syndrome, neurons can sometimes misfire. In this disorder, the person will suddenly hear a loud sound that scares them awake, but this sound never occurred. The condition is harmless, but it can be distressing, and the interruption to the regular sleep pattern can adversely affect one’s health.

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Thankfully, the misfire doesn’t happen regularly. However, on the downside, it becomes difficult to know when it will be triggered so that people living with exploding head syndrome can prepare for it or take some precautionary steps. The most common trigger seems to be stress and extreme fatigue, so reducing these as much as possible in one’s life can minimize the chances of misfiring.

ABC News

5. Auto-Brewery Syndrome (ABS)

This one was featured on an episode of Grey’s Anatomy. A man came into the hospital drunk – but hadn’t consumed a drop. Turns out, auto-brewery syndrome was the culprit. And it’s very real. The person’s digestive organs can produce alcohol when there is a particular type of yeast in the gut. As a result, the person with this syndrome will display all signs of being drunk without actually drinking.

Dr. Phil

Specific yeasts in the gut can produce this “drunk” effect; the problem lies when their numbers become too high in the stomach. Ethanol is made in the digestion process, which creates the drunk effect. This overgrowth is more prominent in those with liver cirrhosis, diabetes, or Crohn’s disease.

Haiku Deck

4. Methemoglobinemia

Methemoglobinemia is a disorder that is related to the blood and is the result of there being very little oxygen in the red blood cells. This results in the pigmentation of the skin is somewhat blue since there is no oxygenation to the extremities. There are other health complications as well, such as difficulties breathing, diarrhea, vomiting, excessive salivation, feeling extremely lethargic, and losing consciousness.

The 1800s “Kentucky Blue People” reveals a family that could have suffered from Methemoglobinemia.

It is an inherited disorder but can also result from exposure to certain drugs or chemicals. Removing the cause will improve the condition. The most common treatment for this disorder is methylene blue, which converts the ferric iron in the hemoglobin into ferrous iron so it can be more readily absorbed. Other treatment options include blood transfusions, oxygen therapy, and ascorbic acid to reduce the methemoglobin level in the blood.


3. Brain Stones

Brain stones, also called cerebral calculi, are calcifications found inside the skull. A young Brazilian male reported having throbbing headaches and problems with his vision, and doctors found brain stones. The doctors believed that the brain stones resulted from complications with celiac disease, which the man didn’t know he had. The only treatment for brain stones is removed through surgery.

Imaging of Brain Stones. Springer Open.

Because brain stones are so rare, there isn’t much literature about the subject, and, as a result, there is no definitive cause for the stones forming. One of the most common symptoms caused by brain stones is headaches, seizures, and behavioral changes. Over time, without treatment, these symptoms only get worse and increase in frequency.


2. Progeria

Progeria is one of the strangest disorders out there. It appears during the early onset of children, usually at the age of 1. However, children never get any bigger by age five, leading to very short stature. By the time a child becomes 10, they already have the appearance of an older adult, with thin skin, pronounced formation of blood vessels, thinning hair, and vascular disease. It’s as if the child is experiencing rapid aging.

Progeria Research

Heart disease develops at this point, and most individuals with the disorder pass away before they reach 30. There is no treatment or cure for the condition, and it is also not an inherited disorder. It is the result of a spontaneous mutation of a gene, so there is no way to predict that this disorder will appear.

Journal of Oral and Maxillofacial Surgery

1. Aarskog Syndrome

Aarskog syndrome is a genetic disorder that affects overall appearance, as well as the skeleton, muscles, and stature. The parts of the body most affected are the face, toes, and fingers. A diagnosis is usually made at the time of birth because of the presence of facial abnormalities: expanded width of the forehead, drooping of the eyelids, wide-set eyes, descending slant of the eye-opening, and hair growth at the widow’s peak.

Medline Plus

Treatment of the syndrome is spread across the treatment of the different symptoms, including dental specialists, speech pathologists, cardiologists, eye specialists, and hearing specialists. You can have growth hormones to help improve height in children and ask about genetic counseling to assess the recurrent risk in families.