
The Disease That Makes Your Hands And Feet Feel Like They’re Burning
Fabry disease is a rare genetic disorder caused by a deficiency of the alpha-galactosidase A enzyme, leading to the buildup of a fatty substance called Gb3 in the body’s cells. This buildup can cause a variety of symptoms, such as pain and burning sensations in the hands and feet, skin rashes and lesions, gastrointestinal issues, eye abnormalities, kidney dysfunction, and heart problems. The disease is primarily inherited in an X-linked pattern and affects males more than females, with symptoms typically appearing in childhood or adolescence and progressing over time. Treatment may include enzyme replacement therapy and other supportive measures to manage symptoms and prevent complications.