
Infecting Patients With Malaria to Treat Complications From Syphilis
For centuries, heat was used to treat mental illness, as it was believed that fever could have a calming effect on epileptics and those suffering from melancholy. In 1917, Julius Wagner Jauregg, an Austrian neuropsychiatrist, discovered the therapeutic value of malaria inoculation in the treatment of dementia paralytica, a complication of syphilis. Patients were injected with malaria and treated with quinine as soon as the syphilis was cured. This treatment was followed in a hospital under strict monitoring of the patients’ vital signs and regular laboratory tests.

Wagner Jauregg’s therapy was highly admired and used for neurosyphilis cases until the 1950s. While malaria therapy was effective in some cases, it was also dangerous and carried significant risks. Malaria itself can be a life-threatening illness, and the treatment required careful monitoring and management to ensure that patients did not develop severe complications. However, with the introduction of penicillin in syphilis treatment, fever therapy became less common. Wagner Jauregg’s study led to all the methods of stress therapy used in psychiatry, such as electric shock and insulin.