In the 1950s and 1960s, researchers made unexpected findings that paved the way for the development of these medications. Drugs such as imipramine and lithium were initially formulated for different purposes. They were later found to possess mood-stabilizing and antidepressant effects. These chance discoveries sparked further investigations, leading to the creation of selective serotonin reuptake inhibitors (SSRIs) and other classes of antidepressants. These medications work by rebalancing chemicals in the brain, alleviating symptoms of depression. The discovery of antidepressants has revolutionized mental health care, providing countless individuals with a viable and effective means of managing their condition. It has not only enhanced the quality of life for numerous patients but also reduced the stigma surrounding mental health, underscoring the significance of scientific exploration in addressing one of the most prevalent health issues of our time.