Bone Marrow Transplantation
The discovery of bone marrow transplantation has led to a paradigm shift in the treatment of hematological disorders and cancers. In the 1950s, E. Donnall Thomas made remarkable advancements in this field. Through extensive research, Thomas observed the successful engraftment of transplanted marrow cells in mice following irradiation of the bone marrow. Building upon this pivotal finding, Thomas pioneered the development of bone marrow transplantation as a viable therapeutic approach for diseases like leukemia and aplastic anemia. Subsequent progress in transplantation techniques, including HLA matching, has significantly improved patient outcomes and reduced complications.