
Mast Cell Activation Syndrome
Mast Cell Activation Syndrome (MCAS) represents one of several Mast Cell diseases (MCD), and its identification poses significant challenges, often leading to misdiagnosis or long periods of going unnoticed. This syndrome manifests through a diverse array of symptoms and can stem from various triggers that may not consistently affect the entire population of those afflicted, and even within an individual with MCAS, the triggers can vary unpredictably.
Mast cell activation constitutes a typical bodily response to potential threats. These activations can result from either an IgE-mediated or a non-IgE-mediated response, both of which can range from mild to severe reactions. Mast Cell Activation Syndrome arises when there is an excessive or inappropriate response by mast cells to a stimulus, whether known or unrecognized, which cannot be attributed to any other underlying disease.