
16. Medications
Some medications warn patients that they can cause fatigue and dizziness. The four big culprits for causing fatigue include antidepressants, antihistamines, blood pressure medication, and anti-anxiety medications. Antidepressants can cause fatigue because they work on regulating serotonin, which is a mood chemical in the brain responsible for sleep. By boosting serotonin, the body’s natural response is to want to sleep more, hence the fatigue. Antihistamines make you drowsy because they block the histamines that cause you to itch and sneeze but are also responsible for your brain’s normal functions. Blocking these histamines stops these functions, leading you to feel drowsy.
Blood pressure medication can make you feel fatigued because they inhibit the production of adrenaline, which makes your heartbeat rapidly; depressing this will lead to a slower heart rate, causing you to feel more tired. Dosages can be reduced to counteract this or to change to an ACE inhibitor that works on lowering blood pressure without making you feel drowsy and tired. Anti-anxiety medications can cause fatigue because they bind to a chemical called GABA, which causes the body and brain to relax. That is to reduce anxiety symptoms, but it can work too well, leaving you feeling extremely tired.