Calcipotriene is a synthetic form of vitamin D. This medication works by slowing down the growth of skin cells in the affected areas. Calcipotriene is available in the form of a cream, ointment, or solution that can be applied directly to psoriasis plaques. It is generally considered safe and well-tolerated, with minimal side effects. However, in some cases, it may cause skin irritation or a burning sensation. Calcipotriene is often used in combination with other psoriasis treatments, such as topical corticosteroids, to enhance their effectiveness. It may take several weeks to see noticeable improvement.