Methotrexate is typically taken orally once per week, and healthcare providers may adjust the dosage based on an individual’s response to the medication and any potential side effects. While methotrexate can be effective in managing psoriasis symptoms, it may take several weeks to see noticeable improvement. It is important to follow a healthcare provider’s instructions carefully when using methotrexate, as the medication can have serious side effects if not used properly. Regular check-ups and blood tests may be necessary to monitor progress and potential side effects. Some common side effects of methotrexate include nausea, fatigue, and headaches. In rare cases, methotrexate can cause liver damage, so it is important to avoid alcohol and to inform a healthcare provider of any other medications or supplements being taken while using methotrexate.