
19. Loneliness, Stress, and Inflammation are All Tied Together.
What isn’t known to many people is that loneliness is very closely tied to signs and the markers of inflammation. Inflammation is a response that your body makes to protect itself from harmful elements; if you cut yourself and see the area around the cut become red and swollen, you are looking at inflammation. Some inflammation is good because it protects you, but chronic inflammation is harmful and causes long-term health problems. More specifically, it is linked to C-reactive protein, interleukin-6, and fibrinogen (present in blood plasma). Furthermore, because loneliness is a chronic condition, this will naturally lead to chronic inflammation that only worsens over time. In turn, inflammation for extended periods can harm the cardiovascular system, leading to other chronic conditions occurring prematurely.
Unfortunately, this isn’t the only system that is affected. Loneliness can also trigger the autonomic nervous system as well as the hypothalamic-pituitary-adrenocortical (HPA) systems. If you trigge these systems too often and for extended periods, they can exacerbate the cardiovascular system, as well as the metabolic and immune systems. In essence, untreated loneliness will head to problems snowballing together. That means the doctor can easily misdiagnose loneliness for something else entirely. If you are wondering why the feeling of loneliness makes you feel all-around lousy, the reason is that your body is reacting to your mental state. Feeling physically awful can make you less motivated to leave your house and strike up the meaningful human connections that fight loneliness.